Distinct genetic architectures and lung eQTLs differentiate mild from moderate-to-severe asthma phenotypes
Genetic research identifies specific markers for mild and severe asthma
This meta-analysis of genome-wide association study data identifies shared and specific genetic architectures for mild and moderate-to-sever…
New genetic mapping reveals distinct biological pathways for mild asthma versus more severe cases, helping identify specific targets for fut…
Interleukin inhibitors in rheumatoid arthritis are associated with increased risk of serious infections and discontinuations
Analysis shows safety risks for rheumatoid arthritis interleukin inhibitors
This systematic review and network meta-analysis of 12,915 patients found that interleukin inhibitors are associated with increased risks of…
A large study of over 12,000 patients reveals that interleukin inhibitors for rheumatoid arthritis are linked to higher rates of infection a…
Digital educational interventions combining food literacy and sustainability targets show preliminary evidence for adolescent engagement
Digital Tools May Help Children Learn About Sustainable Food Systems
This mini review synthesizes evidence regarding digital educational configurations for children and adolescents. The review identifies three…
New research explores how digital tools and family-based programs can teach children about food literacy and sustainable eating habits.
Biological heterogeneity and overlapping phenotypes complicate the classification of allergic rhinitis cases
New research shows allergic rhinitis is more complex than once thought
This narrative review explores the complex biological heterogeneity of the nasal mucosa in allergic rhinitis. It argues that overlapping fea…
Allergic rhinitis is not a single condition. New research shows a complex mix of cells and overlapping symptoms that can make treatment diff…
Hypoxia coordinates cancer stem cell phenotypes with immune-related mechanisms and therapeutic resistance in cancer
Hypoxia Linked to Cancer Stem Cells and Immune Suppression
This systematic review of 14 studies examines how hypoxia and hypoxia-associated signaling influence cancer stem cell (CSC) phenotypes and i…
Low oxygen levels in tumors may help cancer stem cells survive and weaken the immune system's ability to fight the cancer.
Immune-Fibrotic Framework Links Endometriosis and Adenomyosis to Non-Hormonal Targets
New non-hormonal treatment paths for endometriosis and adenomyosis
This mini review reframes endometriosis and adenomyosis as related but not identical immune-fibrotic conditions centered on macrophage-drive…
New research suggests targeting the immune system and tissue scarring to help people with endometriosis who do not respond to hormone therap…
OM-85 did not significantly reduce time to first wheezing lower respiratory tract illness in high-risk children
Trial shows OM-85 does not prevent early childhood asthma
This randomized controlled trial of 822 children at risk for asthma found no significant difference between OM-85 and placebo regarding time…
A large trial of 822 children found that the drug OM-85 did not reduce the risk of wheezing respiratory illnesses in high-risk infants.
Nasal tissue-resident memory T cells may provide a framework for understanding allergic rhinitis relapse
New cellular targets could help manage chronic allergy symptoms
This mini review explores the role of nasal tissue-resident memory (TRM) cells in allergic rhinitis and chronic rhinosinusitis with nasal po…
Scientists are looking at specific immune cells in the nose that might explain why some people's allergies keep coming back.
Thymosin alpha1 plus chemotherapy improves response rates and immune markers in gastric cancer
Thymosin alpha1 combined with chemotherapy shows promise for gastric cancer
This meta-analysis of 1,704 patients found that thymosin alpha1 combined with chemotherapy improved objective response rates (RR = 1.39) and…
Adding thymosin alpha1 to chemotherapy may improve immune response and quality of life for patients with gastric cancer, according to a meta…
CD4+ T cell subset imbalance drives renal inflammation and fibrosis in diabetic kidney disease
T Cell Imbalance Linked to Kidney Damage in Diabetic Patients
This narrative review explores the role of CD4+ T cell subset imbalances in the progression of diabetic kidney disease. The authors synthesi…
New research highlights how specific immune cell imbalances may drive inflammation and scarring in people with diabetic kidney disease.
Anti-KLHL11 encephalitis requires extensive tumor screening as clinical features do not distinguish from malignancy
Doctors find patterns in rare brain inflammation from antibodies
This systematic review of 13 cases of anti-KLHL11 encephalitis without detectable malignancy describes clinical manifestations, neuroimaging…
A rare brain inflammation caused by anti-KLHL11 antibodies can look very similar to cases caused by tumors, making diagnosis difficult.
Knee osteoarthritis research trends show increasing focus on metabolic syndrome and inflammatory signaling
Mapping the Growth and Future Trends in Knee Osteoarthritis Research
This bibliometric and scientometric analysis of 783 publications from 2000 to 2025 identifies a substantial increase in research output afte…
Experts analyzed years of data to find how scientists are changing the way they treat and study knee joint pain.