Pembrolizumab plus chemotherapy improves ORR and OS in HER2-negative advanced gastric or gastroesophageal junction cancer
Pembrolizumab Plus Chemotherapy Improves Outcomes for Advanced Gastric Cancer
This systematic review and meta-analysis of 3406 patients found that pembrolizumab combined with chemotherapy significantly improved objecti…
Adding the drug pembrolizumab to chemotherapy shows promise in improving survival and response rates for patients with advanced gastric canc…
Host-targeting antivirals offer a potential transformative treatment strategy for rhinovirus infection
Host Targeting Antivirals May Offer New Strategy for Common Cold
This systematic review examines host-targeting antivirals (HTAs) as an alternative to direct-acting antiviral drugs for respiratory infectio…
New research explores how host-targeting antivirals could change how we treat common cold infections and help high-risk patients.
Community governance models for nutrition-oriented care aim to reduce survival disparities across multiple cancers
Community governance can improve nutrition care for cancer patients
This mini review explores the role of community governance in integrating nutritional support into oncology services for breast, cervical, o…
Newer policy models aim to bridge the gap in nutrition care, helping women with various cancers access better food security and support.
Vonoprazan therapy associated with anaphylaxis in a patient with pollen-food allergy syndrome
Acid reflux medication linked to severe soy allergy reactions
This case report describes a 59-year-old woman who experienced two episodes of anaphylaxis after consuming soy products while receiving vono…
A woman experienced life-threatening allergic reactions after taking a specific acid reflux medication while consuming soy products.
Endoplasmic reticulum stress and unfolded protein response drive thyrocyte apoptosis and immune cell dysfunction
Endoplasmic Reticulum Stress Linked to Hashimoto's Thyroiditis Development
This narrative review examines the role of endoplasmic reticulum stress (ERS) and the unfolded protein response (UPR) in Hashimoto's thyroid…
New research suggests that cellular stress in the thyroid may play a key role in how Hashimoto's thyroiditis develops and impacts immune cel…
Alpha-gal syndrome review: delayed reactions, 15,000 new US cases yearly
Tick Bite Allergy: 15,000 New Cases Each Year
This mini-review summarizes alpha-gal syndrome (AGS), an IgE-mediated sensitivity to galactose-alpha-1,3-galactose, typically causing delaye…
A tick bite can trigger a delayed meat allergy. New cases in the US are estimated at 15,000 yearly.
Nanotechnology may overcome immune checkpoint blockade resistance in esophageal cancer by reprogramming the tumor microenvironment
Nanotechnology May Help Overcome Treatment Resistance in Esophageal Cancer
This systematic review examines how nanotechnology-enabled immunomodulation can reprogram the tumor microenvironment in esophageal cancer, p…
New research explores how nanotechnology can change the tumor environment to help immune checkpoint treatments work better for esophageal ca…
Surfactant protein D serves as a prognostic marker and potential therapeutic agent in various cancers
Protein D shows promise in diagnosing and treating several cancers
This narrative review explores the role of Surfactant protein D (SP-D) across multiple malignancies, including lung adenocarcinoma and breas…
A specific protein called Surfactant protein D may help doctors identify lung cancer and fight cells in breast and leukemia cases.
Cell surface glycoRNAs engage immune receptors, influencing neutrophil trafficking and immune activation
GlycoRNAs Guide Immune Cells and May Shape Inflammation
This mini-review synthesizes current knowledge on cell surface glycoRNAs and their interactions with immune receptors. It reports that glyco…
GlycoRNAs on cell surfaces interact with immune receptors, guiding neutrophils and influencing immune responses.
Immune checkpoint inhibitors show limited activity in unselected pancreatic ductal adenocarcinoma without specific biomarkers
New Strategies Target Immune Therapies for Pancreatic Cancer
This mini review examines the role of immune checkpoint blockade, vaccines, and cellular therapies in recurrent pancreatic ductal adenocarci…
New research highlights specific ways to better select patients for immune checkpoint inhibitors and advanced cell therapies in pancreatic c…
HLA-B*13:01 screening shows strong association with Dapsone Hypersensitivity Syndrome in leprosy patients
Genetic testing may help identify patients at risk for leprosy side effects
This meta-analysis examines the association between HLA-B*13:01 and Dapsone Hypersensitivity Syndrome (DHS) in leprosy cases. The analysis r…
A genetic test can identify people likely to have a severe reaction to dapsone, a common medication used to treat leprosy.
HLA alleles and haplotypes influence the magnitude of CMV and EBV specific T-cell responses
Genetic Markers Linked to T-cell Responses Against CMV and EBV
This guideline synthesizes observational data regarding how HLA class I and II alleles, haplotypes, and HLA-G 3′UTR polymorphisms impact CMV…
Specific genetic markers may influence how the immune system responds to common viruses like CMV and EBV, potentially helping to select bett…