Stratified MINOCA Tx improves angina status at 12 months vs standard care in PROMISE trial
For heart attacks with clear arteries, does personalized treatment help? New trial shows it improves chest pain.
In the PROMISE RCT (n=92), stratified treatment for MINOCA significantly improved angina status at 12 months vs standard care (mean SAQSS di…
Patients with heart attacks and clear arteries got better chest pain and quality of life after doctors found and treated the specific cause …
Phase 3 trial of milvexian for ACS prevention completes enrollment
Can a new drug help prevent heart attacks and strokes after a serious heart event?
The LIBERATE trial, a Phase 3 study, has completed enrollment of 14,194 participants with a recent acute coronary syndrome to evaluate if mi…
A new drug called milvexian is being tested to see if it lowers the risk of death, heart attack, or stroke after a serious heart event.
Phase 2a trial of DFV890 and MAS825 for inflammation in CHD/CHIP patients completes with 31 participants
Can two experimental drugs calm the dangerous inflammation linked to heart disease and a blood condition called CHIP?
A Phase 2a, multi-center, randomized, placebo-controlled, blinded study evaluated the efficacy, safety, and tolerability of DFV890 (oral dai…
A new trial tested two experimental drugs to safely turn down the dangerous inflammation driving heart disease in patients with CHIP.
Phase 2 trial tests pre-hospital glucocorticoid pulse in STEMI patients undergoing primary PCI
Phase 2 trial tests steroid pulse for heart attack patients before hospital arrival
A phase 2 randomized controlled trial enrolled 530 STEMI patients treated with primary PCI to test single-dose glucocorticoid pulse therapy …
A new trial tested giving a single steroid dose in ambulances before heart attack patients reach the hospital to reduce permanent heart dama…
Phase 2 pilot study evaluates ticagrelor monotherapy safety after stenting for acute MI
Can a single blood thinner prevent heart attacks after stent placement?
A single-center, single-arm, prospective phase II pilot study of 200 patients assessed the initial safety of ticagrelor monotherapy after co…
A new pilot study tests if one blood thinner alone can safely prevent heart attacks and stent clots after stent placement for heart attack p…
Increased LV mass linked to discordant stress CMR/ICA results via microvascular resistance
Why do heart tests sometimes disagree? A thicker heart muscle might be the surprising reason.
In patients with suspected obstructive CAD, left ventricular mass (LVM) was higher in those with abnormal stress CMR vs. normal CMR (median …
A thicker heart muscle can sometimes confuse heart tests, making a normal angiogram look falsely normal even when a problem exists.
Colchicine reduces total plaque burden but not low attenuation plaque in stable CAD patients
Can a cheap anti-inflammatory drug slow heart disease? It might help reduce plaque buildup.
In the EKSTROM RCT (n=84), low-dose colchicine (0.5 mg/day) did not significantly reduce low attenuation plaque volume (median change 0.1 vs…
A cheap anti-inflammatory drug called colchicine may help slow total plaque buildup in arteries for people already managing stable heart dis…
Meta-analysis: Colchicine reduces MACE by 17%, eMACE by 23% in ASCVD
Can an old anti-inflammatory drug help prevent heart attacks? A review of 11 trials suggests it might.
A meta-analysis of 11 trials (n=30,808) found low-dose colchicine was associated with a 17% reduction in MACE (RR 0.83, 95% CI 0.73-0.95; P=…
Adding a low-dose anti-inflammatory drug called colchicine to heart disease treatment lowers the risk of heart attacks and strokes by 17%.
Surgical ablation reduces POAF but increases pacemaker risk in non-mitral valve surgery
For heart surgery patients with AFib, does adding a procedure to fix the rhythm help?
In a meta-analysis of 39,348 AF patients undergoing non-mitral valve surgery, concomitant surgical ablation was associated with a 27% reduct…
Adding a rhythm-fixing procedure during heart surgery significantly lowers AFib return rates but increases the chance of needing a permanent…
Accelerated stress CMR non-inferior to standard protocol, saves 24 minutes per scan
Can a faster heart scan find blocked arteries just as well as the standard test?
In a prospective RCT of 150 patients with suspected angina, an accelerated stress-only CMR protocol was non-inferior to a standard stress-re…
A faster heart scan takes 24 minutes less than the standard test and finds blocked arteries just as accurately for patients with chest pain.
Immediate revascularization tied to higher 1-year risk in STEMI with multivessel disease and heart failure
For heart attack patients with heart failure, does fixing all blockages right away help or hurt?
In the OPTION-STEMI trial, immediate complete revascularization was not non-inferior to staged revascularization. A subgroup analysis found …
For heart attack patients with heart failure, fixing all blockages immediately raises the risk of death or another heart attack within a yea…
EXCEL: Spontaneous MI 2x Higher After PCI vs CABG for Left Main Disease, Strongly Linked to Mortality
After heart surgery for a major blockage, which procedure leads to fewer future heart attacks?
In the EXCEL trial, spontaneous MI within 5 years occurred in 6.8% of PCI patients vs 3.4% of CABG patients (adjHR 2.01; 95% CI, 1.29-3.15; …
After heart surgery for a major blockage, patients with a stent had nearly twice the rate of future heart attacks compared to those with byp…