Icotrokinra 200 mg daily achieves PASI 75 in 73% of patients at Week 16 versus 11% with placebo in moderate-to-severe plaque psoriasis
Oral icotrokinra shows strong results for moderate-to-severe plaque psoriasis
This systematic review and meta-analysis evaluates icotrokinra for moderate-to-severe plaque psoriasis in 1951 patients. The pooled analysis…
A new analysis finds oral icotrokinra helps clear skin faster than placebo in patients with moderate-to-severe plaque psoriasis.
Switching between adalimumab and biosimilar adalimumab-atto shows similar pharmacokinetics in plaque psoriasis
Switching between adalimumab and its biosimilar is safe and similar
This phase 3 RCT in 425 adults with moderate-to-severe plaque psoriasis found that multiple switches between adalimumab RP and biosimilar ad…
A new trial shows that switching between adalimumab and its biosimilar adalimumab-atto is safe and produces similar drug levels in the blood…
Quantitative PDA improves understanding and confidence versus qualitative PDA in dysplastic nevus screening
Quantitative tool improves understanding of dysplastic nevus risk
This randomized A/B testing study enrolled 600 US adults to compare Quantitative PDA against Qualitative PDA for dysplastic nevus screening.…
A new tool that shows numbers about mole risk helped adults understand their dysplastic nevus risk better than a descriptive tool, but did n…
ALK fusion Spitz neoplasms show distinct morphologic patterns and genomic correlates in meta-analysis
ALK fusion Spitz tumors: new patterns linked to behavior
This retrospective cohort study with meta-analysis of 144 patients with ALK fusion Spitz neoplasms describes morphologic patterns and genomi…
Spitz tumors with ALK fusions show distinct shapes and gene partners that may predict which ones turn aggressive.
Mohs micrographic surgery reduces local recurrence by 12% versus superficial radiation therapy in nonmelanoma skin cancer
Mohs Surgery Shows Lower Recurrence Than Radiation for Skin Cancer
This systematic review and meta-analysis compares superficial radiation therapy (SRT) with Mohs micrographic surgery (MMS) for nonmelanoma s…
A large analysis found Mohs surgery had lower recurrence rates than superficial radiation therapy for nonmelanoma skin cancer, with a 12% di…
Cadonilimab plus chemotherapy improves objective response rate to 0.62 in solid tumor patients
Meta-analysis shows cadonilimab plus chemo improves outcomes for solid tumors
This systematic review and meta-analysis evaluated cadonilimab in patients with solid tumors, including gastric cancer and cervical non-smal…
A meta-analysis of 1,359 patients found cadonilimab combined with chemotherapy improved response rates and survival for solid tumors includi…
Real-world meta-analysis of baricitinib for atopic dermatitis shows variable outcomes
Real-world data shows baricitinib helps European patients with severe eczema
This real-world meta-analysis of 264 European patients with moderate-severe atopic dermatitis found that baricitinib improved EASI scores at…
A new analysis of real-world patients found baricitinib reduced eczema severity and itch for many people with moderate-to-severe atopic derm…
Secondary analysis of Phase 3 trials shows lebrikizumab improves absolute EASI response in moderate-to-severe atopic dermatitis
New analysis shows lebrikizumab helps clear skin faster than placebo for atopic dermatitis
This secondary analysis of two Phase 3 trials evaluated lebrikizumab 250 mg Q2W versus placebo in adults and adolescents with moderate-to-se…
A look at two major trials found lebrikizumab led to significantly better skin clearing than placebo in adults and adolescents with moderate…
Narrative review explores gut microbiota links to atopic dermatitis pathogenesis and potential therapeutic strategies
Gut bacteria changes may offer new hope for atopic dermatitis
This narrative review examines the relationship between gut microbiota alterations and atopic dermatitis. The authors discuss dysbiosis, los…
A review suggests that gut microbiome imbalances and specific bacterial changes could play a role in skin inflammation, pointing to new prev…
Systematic review and meta-analysis of AI for melanoma risk assessment in pigmented skin lesions
AI plus doctors finds every skin cancer case in real-world settings
This systematic review and meta-analysis synthesized evidence from 17 diagnostic arms on AI, dermoscopy, and AI-assisted clinicians for mali…
When doctors used AI alongside standard skin checks, they caught every cancer case without missing any, showing a powerful new way to help p…
Review highlights emerging mechanisms for allergic contact dermatitis management
Critical gaps remain in understanding allergic contact dermatitis sensitization thresholds
This narrative review discusses allergic contact dermatitis and notes critical gaps persist regarding tissue-resident memory T cells and pre…
A review of allergic contact dermatitis highlights emerging mechanisms that may support the development of more precise and effective therap…
Marburg MS case shows treatment challenges and fatal outcome
A Rare MS Variant Defied Treatment Until This Switch
A 46-year-old woman with aggressive Marburg MS faced treatment-limiting toxicity and died despite multiple therapies, highlighting urgent ca…
A woman with a rare, aggressive form of multiple sclerosis tried many treatments without success, and doctors tried a new approach too late.