Pivekimab sunirine shows activity in frontline and relapsed Blastic plasmacytoid dendritic cell neoplasm.
A New Drug Shows Striking Promise for a Rare and Aggressive Blood Cancer
This phase I/II single-arm trial evaluated pivekimab sunirine in adults with Blastic plasmacytoid dendritic cell neoplasm (BPDCN). In the pr…
For a cancer with very few options, this therapy is changing the outlook for patients and creating a clear path to potentially curative stem…
Network meta-analysis finds biologics superior to placebo for pediatric plaque psoriasis
Biologic treatments help children with moderate to severe psoriasis, analysis finds.
A network meta-analysis of randomized controlled trials including 1,016 pediatric psoriasis patients found all biologic therapies significan…
Biologic medicines help children with moderate to severe psoriasis achieve clear skin and better quality of life, analysis finds.
Narrative review suggests endovascular treatment may be feasible and safe for posterior epistaxis
Can a minimally invasive procedure stop severe nosebleeds safely?
A narrative review based on a semi-systematic search examined the role of endovascular treatment for posterior epistaxis. The review suggest…
A minimally invasive procedure can safely stop severe, hard-to-reach nosebleeds, but doctors must first map blood vessels to avoid dangerous…
Outpatient IV sedation for dental care in special needs patients shows 3.3% minor complication rate
Study describes use of IV sedation for dental care in patients with special needs
A retrospective cohort study of 212 special health care needs patients (mean age 11.1 years) undergoing outpatient IV sedation for dental pr…
Over 2,200 dental procedures were safely performed on children with autism and Down syndrome using IV sedation at a Venezuelan clinic, with …
Bimekizumab maintains complete skin clearance in 73% of psoriasis patients at 4 years
Can psoriasis treatment keep skin clear for years? New data suggests it might.
A pooled analysis of phase 3 trials and open-label extension in 503 psoriasis patients found 73.0% of those achieving complete clearance at …
After four years on bimekizumab, about 73% of patients with psoriasis kept their skin completely clear, suggesting the treatment may help re…
PD-L1 expression shows subtype-specific prognostic value in skin neoplasms, meta-analysis finds
Does a common cancer marker predict survival in skin cancers? It depends.
A meta-analysis of 24 observational studies found PD-L1 expression was not significantly associated with overall survival (HR=0.89, 95% CI: …
A common skin cancer marker doesn't predict survival for everyone, but it does for specific types like Merkel cell carcinoma and melanoma.
Early proactive TCS for infant AD linked to lower food allergy rates at age 3
Early eczema treatment in infants linked to lower food allergy risk at age three
A 3-year follow-up RCT of 590 children found early proactive topical corticosteroid treatment for infant atopic dermatitis was associated wi…
Treating infant eczema early and consistently lowered food allergy rates at age three, with fewer cases of egg allergy and pollen sensitivit…
Meta-analysis compares HAQ-DI, SF36-PF, and SF36-PCS for physical function in psoriatic arthritis trials
Which tool best tracks physical changes in psoriatic arthritis patients?
A meta-epidemiological study of 42 articles (31 RCTs) in psoriatic arthritis found HAQ-DI and SF36-PF were more responsive to change than SF…
Doctors can track psoriatic arthritis improvements more clearly with two specific tools that spot physical changes better than the third com…
Centralized hair loss measurement showed better agreement and 50% lower error margins than local rating in mild-to-moderate Alopecia Areata.
Centralized hair loss scoring showed better consistency than local ratings in mild Alopecia Areata trials
This Phase 2 clinical trial compared centralized measurement of hair loss via standardized photographic images against local SALT score rati…
Centralized hair loss scoring cut measurement errors by half compared to local ratings in mild Alopecia Areata trials, boosting trial succes…
AI pipeline shows substantial agreement with dermatologists for grading atopic dermatitis erythema severity
Can AI help doctors measure eczema severity from photos?
A cross-sectional validation study of 41 AD lesion images found an AI pipeline demonstrated substantial agreement with dermatologist consens…
An AI system graded eczema redness 81% of the time like expert doctors, showing promise for tracking flare-ups from photos.
Retrospective analysis identifies molecular correlates of benefit with encorafenib-based therapy in BRAF-mutant melanoma
Melanoma study finds tumor genetics and immune markers may predict treatment benefit
A retrospective exploratory analysis of the phase III COLUMBUS trial in 921 patients with BRAF V600E/K-mutant advanced melanoma found that s…
Patients with advanced melanoma who have higher tumor mutational burden or signs of immune system activity gain the most survival benefit fr…
Meta-analysis finds oral JAK inhibitors increase HDL and LDL cholesterol levels in patients from RCTs
Common arthritis and skin drugs linked to cholesterol changes, analysis finds
A systematic review and meta-analysis of 13 phase 2 and 3 RCTs involving 5,658 patients found treatment with oral JAK inhibitors (baricitini…
Common arthritis and skin drugs can raise both 'good' and 'bad' cholesterol levels, a review of nearly 4,000 patients shows.