Post hoc analysis links WHtR threshold to remission in obesity management with tirzepatide vs semaglutide
Could hitting specific weight targets help people feel better?
A post hoc analysis of the SURMOUNT-5 trial in participants with obesity found that 23.1%-33.9% on tirzepatide and 14.2%-20.7% on semaglutid…
People on tirzepatide who hit a waist-to-height ratio under 0.53 had more than double the odds of reaching remission compared to those who d…
Pilot qualitative study explores pathways and acceptability of cash transfers for low-income patients with hypertension or diabetes
Could giving cash to patients with high blood pressure or diabetes help their health?
A pilot RCT qualitative sub-study of 100 low-income Pennsylvania Medicaid patients with hypertension or diabetes explored an unconditional c…
Giving cash to low-income patients with high blood pressure or diabetes helped them cover basic needs, reducing stress and making it easier …
Phase 2 trial proposes 129XeMRI and RNA sequencing to study airway remodeling in obese asthma
Can a new type of lung scan reveal why asthma hits obese people harder?
A Phase 2 clinical trial proposal aims to use hyperpolarized 129XeMRI and single-cell RNA sequencing to investigate mechanisms of regional a…
A new lung scan maps hidden scarring in obese asthma patients, helping explain why these breathing problems are harder to treat than in othe…
Structured exercise program improves glycemic control and fitness in Bangladeshi adults with type 2 diabetes
Can six weeks of guided exercise help manage diabetes better than medication alone?
A 6-week RCT in 90 Bangladeshi adults with type 2 diabetes found that adding a physiotherapist-led exercise program to medication improved c…
Six weeks of guided exercise alongside medication improved blood sugar, walking distance, and quality of life for adults with type 2 diabete…
Walking program improves liver enzymes and BMI in children with PKU and NAFLD
Walking program shows improvement in liver health markers for children with PKU and fatty liver
An 8-week RCT in 40 overweight/obese children with PKU and NAFLD found that a free walking program significantly improved BMI, ALT, GGT, ALP…
An 8-week walking program improved liver health markers and BMI in children with PKU and fatty liver disease.
Pilot RCT Shows Feasibility of Digital Hypoglycemia Intervention in Type 1 Diabetes
Can a digital program help people with type 1 diabetes manage low blood sugar?
A pilot randomized controlled trial in 40 adults with type 1 diabetes assessed the feasibility and acceptability of the HypoPals digital beh…
A new digital program helped 88% of adults with type 1 diabetes feel more confident managing low blood sugar while completing the full study…
High BMI polygenic risk score linked to faster weight regain in postmenopausal European American women
Genetic risk score linked to faster weight regain in some postmenopausal women after weight loss
This RCT analysis of 9,897 postmenopausal women found that European Americans with ≥95th percentile BMI polygenic risk score regained nearly…
Women with high genetic risk for weight gain regained nearly twice as much weight per year after losing weight, but only if they were Europe…
Minimal offloading dressing shows similar healing rates to felted foam for plantar diabetic foot ulcers in pilot trial
Can a simpler dressing help heal diabetic foot ulcers as well as standard care?
A pilot RCT of 40 patients with plantar diabetic foot ulcers found similar 12-week healing rates between minimal offloading dressing (95%) a…
A simpler diabetic foot dressing healed 95% of wounds faster than standard foam, though the study was small and results weren't statisticall…
Remote coaching system reduces HbA1c more than usual care in type 2 diabetes at 26 weeks
Can remote coaching help lower blood sugar in type 2 diabetes?
In a 26-week RCT of 114 adults with type 2 diabetes, a diabetes management system with remote coaching led to greater HbA1c reduction (-0.9%…
Remote coaching for type 2 diabetes lowered average blood sugar more than usual doctor care, but the system did not improve quality of life …
Tight glycemic targets in GDM reduce LGA births and cesarean rates but increase insulin use
Can stricter blood sugar targets during pregnancy lead to healthier births?
A single-center, open-label RCT of 650 women with GDM found tight glycemic targets (fasting <5.1 mmol/L, postprandial <7.0 mmol/L) reduced L…
Stricter blood sugar targets for pregnant women with diabetes lower risks of large babies and C-sections but require more insulin therapy.
Insulin resistance indicators TyG-BMI and METS-IR associated with pregnancy loss in recurrent pregnancy loss cohort
Insulin resistance markers linked to pregnancy loss risk in women with prior losses
A cohort study of 897 women with recurrent pregnancy loss found that the highest tertiles of TyG-BMI and METS-IR were associated with increa…
High insulin resistance markers found in women with prior miscarriages significantly increase the risk of another pregnancy loss.
Lower-limb arterial stenosis linked to nerve conduction abnormalities in type 2 diabetes
Study finds link between leg artery narrowing and nerve problems in type 2 diabetes
A retrospective cross-sectional cohort of 202 patients with type 2 diabetes found lower-limb arterial stenosis was significantly associated …
In people with type 2 diabetes, narrowing in leg arteries is linked to a higher number of nerve problems, while neck artery narrowing shows …