Phase II RCT finds no OS benefit for hepatectomy in colorectal cancer with liver and lung metastases
Does removing liver tumors help when lung tumors remain? A small trial offers mixed answers
A phase II randomized trial in 27 patients with colorectal adenocarcinoma and resectable liver/unresectable lung metastases compared hepatec…
A small trial stopped early found no survival benefit for liver surgery when lung tumors remain, yet patients who actually got the operation…
Qualitative analysis explores LARS self-management experiences via online peer support app
Rectal cancer survivors share experiences using online peer support app for bowel symptoms
A qualitative analysis of 45 rectal cancer survivors with low anterior resection syndrome (LARS) participating in an online peer support app…
Rectal cancer survivors found comfort in an online app where peer support and diet tips helped them manage painful bowel symptoms after surg…
8-week glecaprevir/pibrentasvir shows 96.2% SVR12 in acute HCV treatment-naïve adults
Can a short treatment course cure most cases of acute hepatitis C?
A single-arm Phase IIIb study of 286 treatment-naïve adults with acute HCV found 96.2% achieved SVR12 with an 8-week glecaprevir/pibrentasvi…
A short eight-week treatment cured 96.2% of adults with new hepatitis C infections, with a perfect success rate for those who completed the …
Genetic study links H. pylori susceptibility to HLA and innate immunity genes, suggests causal disease relationships
Large genetic study finds links between H. pylori infection susceptibility and autoimmune diseases
A meta-analysis of up to 140,863 Japanese and European individuals identified significant genetic associations for H.
A large genetic study reveals specific immune system genes linked to H. pylori infection and autoimmune diseases like type 1 diabetes and Ha…
Systematic review finds inconsistent microbiome findings in alcohol-associated liver disease
Can fixing your gut help heal a liver damaged by alcohol?
A systematic review examined gut microbiome interactions and therapeutic strategies in patients with alcohol-associated liver disease.
Fixing gut bacteria with probiotics or transplants might help heal alcohol-damaged livers, but inconsistent study results make it hard to kn…
Review describes Borrelia burgdorferi immune evasion strategies that enable persistent infection across vertebrate hosts
Review explains how Lyme disease bacteria persist by altering host immune responses
A systematic review synthesizes evidence on Borrelia burgdorferi immunobiology in vertebrate hosts, including humans.
Lyme disease bacteria survive by redirecting the immune system to avoid full elimination, allowing the infection to persist across different…
HBV RNA positivity at nucleoside analogue discontinuation linked to higher relapse risk in chronic hepatitis B
What happens when hepatitis B patients stop their medication? A key marker may predict relapse
A meta-analysis of 21 cohort studies including 2,043 chronic hepatitis B patients found HBV RNA-positive individuals had 1.9-fold higher vir…
Stopping hepatitis B medication carries higher relapse risk if a specific viral marker called HBV RNA is still detectable in the blood.
HCV treatment with direct-acting antivirals linked to reduced alcohol use in people who inject drugs
HCV treatment linked to reduced alcohol use in people who inject drugs
A secondary analysis of a pragmatic RCT in 755 people who inject drugs (PWID) found that achieving sustained virological response (SVR) was …
People who inject drugs and cured of hepatitis C showed lower alcohol use scores at every follow-up visit compared to their baseline.
Meta-analysis finds 15.4% pooled TTI prevalence in Cameroonian blood donors, higher risk in family donors
How many blood donations in Cameroon carry dangerous infections?
A systematic review and meta-analysis of 36 studies involving approximately 105,000 blood donations in Cameroon found a pooled transfusion-t…
A new analysis of over 100,000 blood donations in Cameroon found that 15.4% carry dangerous infections like HIV, hepatitis, or syphilis, wit…
Oyster-derived bioactives show hepatoprotective effects in animal models of alcoholic liver disease
Could oyster compounds help protect the liver from alcohol damage?
A systematic review and meta-analysis of 11 studies (10 animal, 1 human trial) found oyster-derived compounds reduced liver enzymes by 34-56…
Oyster compounds may protect the liver from alcohol damage in animals by lowering injury markers and boosting antioxidant defenses, though h…
Review finds probiotic-mast cell interplay in gut inflammation remains poorly defined
Review finds limited understanding of how probiotics interact with gut cells in inflammation
A systematic mini-review synthesizing existing evidence found the functional interplay between probiotics and mast cells in gut health and d…
Probiotics and gut immune cells called mast cells might interact to influence inflammation in conditions like food allergies, but scientists…
Adjuvant NSAIDs associated with improved DFS in resected PIK3CA-mutated colorectal cancer
NSAID therapy after surgery may help prevent colorectal cancer recurrence in some patients
A meta-analysis of 789 patients with resected PIK3CA-mutated colorectal cancer found adjuvant NSAID therapy (aspirin or COX-2 inhibitors) wa…
Taking anti-inflammatory drugs like aspirin after colorectal cancer surgery may lower the risk of the cancer returning in patients with a sp…