Maintaining gut microbiome integrity should be a fundamental component of antimicrobial stewardship strategies aimed at controlling AMR worldwide
Doctors suggest fixing gut bugs is key to fighting antibiotic resistance globally
This narrative review discusses the role of various interventions in human gut microbiota. The authors argue that maintaining and re-establi…
Antibiotics often harm helpful gut bacteria, making infections worse. New treatments like phage therapy and stool transplants aim to restore…
Mid-turbinate swabs match nasopharyngeal swab sensitivity for any respiratory virus in children
Mid-turbinate swabs match the gold standard for catching kids respiratory viruses
This systematic review and meta-analysis evaluated diagnostic accuracy of nasopharyngeal aspirates, mid-turbinate swabs, anterior nasal swab…
Mid-turbinate swabs match the gold standard for catching kids respiratory viruses while being far more comfortable than the current method.
Bacterial contamination prevalent in ready-to-eat salads across Africa: meta-analysis
Four out of ten salads in Africa carry dangerous bacteria like E. coli
A systematic review and meta-analysis of 31 studies found high pooled prevalence of bacterial pathogens in ready-to-eat vegetable salads acr…
A review of 31 studies found that nearly half of ready-to-eat vegetable salads across Africa contain harmful bacteria like E. coli and Salmo…
43% of Pseudomonas aeruginosa isolates in Indonesia are carbapenem-resistant, meta-analysis finds
High rates of drug-resistant bacteria found in hospital samples across Indonesia
A systematic review and meta-analysis of 16 studies including 3,852 Pseudomonas aeruginosa isolates from Indonesia found a pooled carbapenem…
A review of nearly four thousand bacteria samples from Indonesia shows that almost half are resistant to strong antibiotics. This finding hi…
Source control and antibiotic stewardship remain cornerstones of sepsis management
Review prioritizes antibiotic stewardship over live probiotics for sepsis
This narrative review synthesizes current evidence on sepsis management, emphasizing source control and antibiotic stewardship as key pillar…
A narrative review suggests avoiding live probiotics in high-risk sepsis patients while prioritizing antibiotic stewardship and source contr…
Digital AMS tools show no significant impact on antibiotic prescribing or patient outcomes
Digital tools show no clear benefit for antibiotic use or patient outcomes
A meta-analysis of eleven RCTs found digital antimicrobial stewardship interventions did not significantly improve antibiotic appropriatenes…
A large review of trials found digital antimicrobial stewardship tools did not significantly change antibiotic prescribing or patient health…
Antibiotic stewardship bundle aims to cut antibiotic use in Chinese NICUs
A new plan aims to cut unnecessary antibiotics for sick newborns in China
This protocol describes a multicenter, before-and-after, interrupted time series quality improvement study testing a bundled antimicrobial s…
This ongoing project in China seeks to reduce antibiotic use for newborns with sepsis while keeping them safe during treatment.
Hospital-based screening yields 18% CRE colonization prevalence, 20% with universal screening
Hospital settings show higher CRE colonization rates than community locations
This systematic review and meta-analysis of 116,743 participants across 89 studies found a pooled CRE colonization prevalence of 14%. Hospit…
A large analysis of over 116,000 people found that hospital settings have much higher rates of CRE colonization compared to community settin…
Adjunctive corticosteroids may modestly reduce hospital stay for bacterial facial infections but evidence certainty is low
Adding steroids to facial infection treatment may shorten hospital stays by about one and a half days
This systematic review and meta-analysis evaluated adjunctive corticosteroid therapy versus standard treatment alone in patients with bacter…
A large review found that adding steroids to standard care for facial infections might shorten hospital stays, but the evidence is not yet s…
F/TAF PrEP shows similar HIV incidence to F/TDF in cisgender women but noninferiority not proven
PrEP pill F/TAF shows similar HIV prevention as F/TDF in women
This RCT in 1380 predominantly cisgender women in East and South Africa compared daily oral F/TAF vs F/TDF for HIV PrEP over 6 months. HIV i…
A study in African women found that a newer PrEP pill (F/TAF) prevented HIV at similar rates to the standard pill (F/TDF), but the study was…
Immediate antituberculosis therapy did not reduce mortality in HIV-related sepsis overall
Immediate TB treatment helps only those with confirmed infection in HIV sepsis
This trial investigated whether starting antituberculosis treatment immediately or using high doses improved survival in adults with HIV-rel…
In HIV sepsis, starting TB drugs immediately did not lower death rates overall, but helped only patients later confirmed to have TB.
Model-informed precision dosing improves vancomycin target attainment in critically ill children compared to standard therapeutic drug monitoring
New dosing model helps severely ill children hit drug targets faster
In critically ill children, model-informed precision dosing significantly improved vancomycin target attainment versus standard monitoring. …
A new dosing method helped more critically ill children reach the right drug levels in their blood within two days of starting treatment for…