Lp-PLA2 activity does not significantly modify dual antiplatelet therapy efficacy in minor stroke/TIA with CYP2C19 loss-of-function alleles
Blood enzyme levels don't change which stroke prevention drug works better, study finds
This subgroup analysis of the CHANCE-2 RCT examined 5919 patients with minor stroke/TIA and CYP2C19 loss-of-function alleles. Lp-PLA2 activi…
A simple blood test for inflammation doesn't predict which stroke prevention drug works best for patients with a specific genetic trait.
Meta-analysis finds nonlinear dose-response between physical activity and reduced stroke risk
How much exercise protects against stroke? A new analysis finds the sweet spot.
A meta-analysis of 14 prospective cohort studies with 2.6 million participants found nonlinear inverse associations between physical activit…
A new analysis of over 2.6 million people finds that moderate exercise—like a few vigorous workouts weekly—can cut stroke risk by up to 19%,…
Para-aural mineralization found in 0.8% of canine head CTs, associated with tympanic bulla disease
What does a tiny spot of calcium near a dog's ear mean for its health?
A retrospective case-control study of 1833 canine head CTs found para-aural mineralization in 15 dogs (0.8%). Cases had significantly higher…
A tiny calcium spot near a dog's ear often signals hidden middle-ear disease, appearing in 87% of affected dogs compared to just 43% of othe…
PTPN1 variants identified in 17% of AGS cohort with later onset and reduced penetrance
Could a common gene variant explain some cases of a rare childhood brain disease?
A genomic cohort study identified ultra-rare heterozygous PTPN1 variants in 9 of 53 individuals with suspected Aicardi-Goutières syndrome (A…
A common gene variant linked to autoimmune conditions may explain some cases of a rare childhood brain disease that starts later than usual.
High-dose thiamine use increased for Wernicke encephalopathy in Japan; functional impairment common at discharge.
Did more high-dose vitamin B1 help patients with alcohol-related brain damage?
A 13-year observational study of 7,856 hospitalized Wernicke encephalopathy patients in Japan found initial high-dose thiamine use increased…
Despite a surge in high-dose vitamin B1 use for alcohol-related brain damage, over half of patients still leave the hospital unable to care …
Case series finds brain morphology alterations in 11 patients with NGLY1 Deficiency
Brain scans show structural differences in patients with rare NGLY1 Deficiency
A case series of 11 patients with NGLY1 Deficiency analyzed 16 real-world MRI scans against normative models. It found pervasive, age-depend…
Researchers analyzed brain scans from 11 patients with the ultra-rare genetic disorder NGLY1 Deficiency. They found widespread structural di…
NODDI MRI shows phenotype-specific white matter alterations in Wilson disease patients
What does Wilson disease do to the brain's wiring? A new scan shows specific damage.
An observational study of 30 Wilson disease patients and 30 matched controls found phenotype-specific microstructural white matter alteratio…
A new brain scan reveals specific wiring damage in Wilson disease patients, linking reduced nerve fiber density directly to slower processin…
Spinal cord injury linked to altered cortical excitability response to repeated tDCS
Could a brain's 'reset button' work differently after spinal cord injury?
A crossover study in 20 adults with thoracic or below spinal cord injury and 20 healthy controls found greater corticomotor excitability fac…
After spinal cord injury, the brain's 'reset button' may weaken, leading to greater excitability and potentially explaining persistent sympt…
Cognitive training perspectives show no significant far transfer effects in acute stroke rehabilitation trial
Can changing how stroke patients think about space help their mood and movement?
A randomized clinical trial of 128 acute stroke patients found that adding allocentric or egocentric perspective cognitive training to conve…
Adding mental exercises to stroke rehab did not improve mood or movement compared to standard care alone in a study of 128 patients.
High-dose melatonin linked to hepatotoxicity in small PP-MS trial, prompting early halt
High-dose melatonin trial halted after liver safety concerns in MS patients
A phase I/II RCT of 8 patients with PP-MS on stable ocrelizumab found that adjunctive high-dose oral melatonin (300 mg/day) was associated w…
A high-dose melatonin trial for multiple sclerosis stopped early after three of four patients developed mild liver injury, though the issue …
Methodological analysis questions predictive value of plasma p-tau217 disease clocks for Alzheimer's onset
Study questions how well a blood test predicts Alzheimer's disease symptom timing
A methodological analysis of ADNI data from individuals who progressed to symptomatic Alzheimer's disease found that baseline age alone expl…
A new analysis suggests Alzheimer's blood test models may overstate their accuracy because they rely mostly on age rather than actual biomar…
Meta-analysis finds depression associated with elevated Parkinson's disease risk
Could depression be an early sign of Parkinson's disease?
A meta-analysis of observational studies found depression was associated with approximately double the risk of developing Parkinson's diseas…
People with depression are about twice as likely to develop Parkinson's disease later, and brain scans in late-onset depression often show e…