High-dose ocrelizumab 1200/1800 mg shows no significant difference in disability progression versus 600 mg in MS
High-dose ocrelizumab did not further reduce disability progression in multiple sclerosis patients
This phase 3b randomized controlled trial in 860 and 753 patients with relapsing or primary progressive multiple sclerosis found that high-d…
A large trial found that higher doses of ocrelizumab did not lower the risk of disability progression compared to the standard dose in multi…
Ocrelizumab reduces disability progression risk in primary progressive multiple sclerosis versus placebo
Ocrelizumab reduces disability risk for primary progressive multiple sclerosis patients
This phase 3b trial evaluated intravenous ocrelizumab versus placebo in patients with primary progressive multiple sclerosis. The study foun…
A large trial found ocrelizumab significantly lowers the risk of disability progression in patients with primary progressive multiple sclero…
Prasinezumab showed non-significant delay in motor progression versus placebo in early-stage Parkinson's disease
Early Parkinson's drug trial shows no delay in motor progression
This phase 2b trial evaluated intravenous prasinezumab in individuals with early-stage Parkinson's disease on stable medication. The study f…
A Phase 2b trial of prasinezumab in early Parkinson's disease failed to meet its primary endpoint of delaying motor progression compared to …
Robot-assisted gait training improves walking ability and functional independence in spinal cord injury
Robot training improves walking after spinal cord injury
This systematic review and meta-analysis of 241 participants with spinal cord injury found that robot-assisted gait training led to signific…
Robot-assisted gait training helps people with spinal cord injury walk farther and more independently than standard rehab alone.
T cell-microglial interactions drive aging and myelin changes in neurodegeneration models
Aging changes brain cells and invites immune cells that hurt nerve repair
This narrative review synthesizes evidence from murine models on T cell-microglial interactions in aging and neurodegeneration. It argues th…
Aging alters brain cell signals and brings in immune cells that damage myelin and stop nerve repair in mouse models.
Sleep and circadian rhythm alterations associate with prolonged ventilation and worse outcomes in adult ICU patients
Disrupted sleep in the ICU linked to worse outcomes
This narrative review examines sleep and circadian rhythm alterations in adult ICU patients. The authors synthesize associations between dis…
Poor sleep in the ICU is tied to longer ventilation, delirium, and lasting health problems. New review highlights the hidden cost of broken …
Network meta-analysis compares alteplase, tenecteplase, and JX10 for acute ischemic stroke treatment outcomes
New analysis compares three clot-busting drugs for stroke patients treated up to twenty-four hours after symptoms start
This network meta-analysis evaluated intravenous thrombolytic agents for acute ischemic stroke. Alteplase significantly improved functional …
A large review found one standard drug helped more patients walk again than usual care, while a new drug showed promise but needs more testi…
Non-invasive neural stimulation improves upper limb function in subacute stroke: meta-analysis
Brain stimulation may help stroke survivors regain arm function
A systematic review and meta-analysis of 24 RCTs (1091 patients) found that non-invasive neural stimulation (NINS) was associated with stati…
A review of 24 trials finds that non-invasive brain stimulation may modestly improve arm movement and daily activities after stroke, but evi…
Protocol outlines planned network meta-analysis of electromagnetic stimulation for post-stroke lower limb dysfunction
Planned review to guide electromagnetic stimulation for stroke recovery
This document is a protocol for a systematic review and network meta-analysis focused on electromagnetic stimulation protocols for patients …
A planned protocol outlines how researchers will evaluate electromagnetic stimulation for stroke patients with leg movement issues before an…
Genetic variants and environmental factors like PM2.5 exposure may increase asthma risk in susceptible individuals
Asthma risk tied to genes and air pollution
This narrative review examines asthma heritability and environmental risk factors. Currently identified genetic variants explain only part o…
A review finds that air pollution and genes both shape asthma risk, but current genetics only explain part of the story.
Meta-analysis suggests specific rTMS protocols improve cognitive and functional outcomes in stroke survivors
Brain Stimulation Improves Thinking After Stroke
This Bayesian network meta-analysis evaluated repetitive transcranial magnetic stimulation (rTMS) protocols in 2543 patients with post-strok…
A new analysis finds that specific types of brain stimulation can boost memory and daily function after a stroke.
Network meta-analysis of Tuina-based combination therapies versus oral medication for insomnia
Tuina combination therapies beat oral medication for insomnia in this exploratory review
This systematic review and network meta-analysis evaluated Tuina-based combination therapies against oral medication in 2,663 subjects with …
Combining Tuina with breath guiding, music, or foot baths worked better than oral medication for insomnia in this review of 2,663 patients.