Tenecteplase and alteplase improve functional outcomes in extended windows but increase symptomatic intracranial hemorrhage risk
Tenecteplase Shows Potential Benefits for Late Acute Ischemic Stroke
This meta-analysis of 4,944 patients evaluated intravenous thrombolysis with alteplase or tenecteplase between 4.5 and 24 hours after stroke…
Tenecteplase may offer similar benefits to alteplase for stroke patients while potentially carrying a lower risk of brain bleeding.
Transcranial pulse stimulation improves MMSE and MoCA scores in patients with Alzheimer's disease
Different brain stimulation methods show specific benefits for Alzheimer's
This network meta-analysis of 1,445 patients evaluated various neuromodulation techniques for Alzheimer's disease. The analysis found that t…
New research shows that different types of brain stimulation can improve specific symptoms of Alzheimer's, from memory to daily activities.
Adjunctive acupoint application increases clinical response rates in post-stroke sleep disorders
Chinese herbal acupoint application may improve sleep after a stroke
This meta-analysis of 608 patients found that adjunctive acupoint application significantly increased trial-defined clinical response rates …
New data suggests that adding herbal acupoint treatments to care can improve sleep quality for people living with sleep disorders after a st…
Detectable Microembolic Signals on TCD Linked to 2.85-Fold Higher Odds of Poor Stroke Outcome
Microembolic signals predict poor outcomes for stroke patients
This meta-analysis of 1,777 patients with acute ischemic stroke found that detectable microembolic signals on transcranial Doppler were asso…
Detecting specific microembolic signals during a stroke can help doctors identify patients at a higher risk for poor physical recovery.
Obstetric CVST: 8.28% maternal mortality acutely, 3.17% recurrence in follow-up cohorts
Anticoagulants show mixed results for pregnant women with blood clots
This meta-analysis synthesizes outcomes across two distinct obstetric cerebral venous sinus thrombosis populations: acute CVST and women wit…
New data reveals that while some pregnant women with blood clots face high risks, others with known history show good delivery outcomes.
Low Dose Ticagrelor and Aspirin Reduce Early Neurological Deterioration in Ischemic Stroke
Trial shows ticagrelor and aspirin may reduce neurological decline
A randomized trial suggests that low-dose ticagrelor combined with aspirin significantly reduces early neurological deterioration in high-ri…
A new clinical trial suggests that a specific combination of ticagrelor and aspirin may help prevent early neurological decline after a stro…
Citicoline increases likelihood of achieving minimal clinically important difference in Parkinson's disease by OR 2.06
Trial shows citicoline may improve movement in Parkinson's disease
This randomized, double-blind, multicenter trial of 485 patients with Parkinson's disease found that citicoline (1000 mg/day intramuscular) …
A new trial suggests that adding citicoline to standard medication may improve motor function and quality of life for people with Parkinson'…
Opioid flexion phenotype is a descriptive term for sustained forward flexion in fentanyl exposure
Opioid Flexion Phenotype Helps Identify Potential Toxicity in Overdoses
This narrative review describes the opioid flexion phenotype in patients with fentanyl exposure. The authors clarify that this posture is a …
A specific forward-leaning posture in opioid use may signal potential toxicity and help first responders prioritize life-saving ventilation.
Digitally Enhanced Composite Endpoints Improve Efficiency in Multiple Sclerosis Clinical Trials
New Digital Tools May Speed Up Clinical Trials for MS
Integrating remote smartphone-based gait assessments with clinical progression events significantly reduces required sample sizes and trial …
A new digital method for tracking movement could allow researchers to reach results faster and with fewer patients in multiple sclerosis tri…
Non-invasive brain stimulation shows favorable tolerability and 94.9% completion rate for post-stroke upper limb rehabilitation
Brain Stimulation Shows Good Safety for Post-Stroke Arm Recovery
This systematic review and network meta-analysis of 2,640 participants evaluated non-invasive brain stimulation (NIBS) for post-stroke upper…
Brain stimulation techniques show high completion rates and favorable safety for patients recovering arm movement after a stroke.
Neurofeedback shows potential for motor and non-motor outcomes in idiopathic Parkinson's disease
New neurofeedback methods show potential for Parkinson's disease patients
This narrative review explores the neurophysiological feasibility and clinical effects of EEG-based, fMRI-based, and DBS-guided neurofeedbac…
New research explores how brain-training techniques like neurofeedback might help people with Parkinson's manage movement and motor symptoms…
Acupuncture-based interventions improve Fugl-Meyer Assessment scores for post-stroke foot drop compared to conventional treatment
Acupuncture may improve movement for patients with post-stroke foot drop
This meta-analysis of 4,596 patients found that acupuncture-based interventions, including traditional and electroacupuncture, improved Fugl…
Acupuncture combined with standard care may help stroke survivors regain movement and improve scores in foot drop recovery.