Semaglutide associated with 35.2% of weight loss as lean mass versus 26.2% with lifestyle interventions
New analysis shows weight loss drugs and lifestyle changes affect muscle loss similarly
This systematic review and meta-analysis evaluated 15 782 adults with overweight or obesity receiving incretin-based therapies or intensive …
A large review of 15,782 adults found that weight loss drugs and lifestyle changes led to similar proportions of muscle loss during weight r…
Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults
Pre-existing health conditions may slightly reduce weight loss after surgery
A meta-analysis of twenty-three studies reveals that mental illness, diabetes, and sleep apnea are associated with slightly lower weight los…
Adults with mental illness or diabetes before surgery saw slightly less weight loss. Other conditions like high blood pressure did not affec…
Vitamin D's role in antifungal immunity remains uncertain due to species differences
Primate biology limits how rodent vitamin D data applies to human fungal infections
This narrative review examines the potential role of vitamin D in antifungal immunity. The authors synthesize evidence from animal models bu…
A review notes that species differences and model limitations prevent direct translation of rodent findings to human fungal disease treatmen…
NAD+ repletion via NMN or NR shows context-dependent effects on muscle stem cell homeostasis and sarcopenia
NAD+ boosters may help muscle stem cells fight aging weakness
This systematic review synthesizes nearly 60 representative preclinical and clinical studies on NAD+ repletion for sarcopenia. The authors d…
A review of nearly 60 studies suggests NAD+ precursors like NMN or NR could support muscle stem cells and reduce oxidative stress in sarcope…
Tirzepatide maximum tolerated dose leads weight reduction ranking in obesity network meta-analysis
New analysis shows weight loss drugs work best for adults with obesity without diabetes
This systematic review and network meta-analysis of 14,059 adults with obesity without diabetes ranked GLP-1 receptor agonists and a dual ag…
A large review of many studies found that specific injectable medicines help adults lose weight. Tirzepatide worked best, but all options re…
Insulin degludec/liraglutide ranks highest for HbA1c reduction with SUCRA value of 89.4%
Comparing Combination Diabetes Drugs for Blood Sugar Control
This network meta-analysis evaluated 12,815 patients with type 2 diabetes to compare fixed-ratio combination products and their individual c…
A review of 12,815 patients found that insulin degludec/liraglutide may be best for lowering blood sugar, but has more side effects than oth…
Modulating endogenous PYY expression offers a theoretical basis for individualized obesity management strategies
Ways to boost body's fullness hormone for weight control
This narrative review discusses modulating endogenous PYY expression via dietary interventions, bariatric surgery, exercise therapy, and phy…
This review explores how diet, surgery, and exercise can raise PYY levels, helping people feel fuller and manage weight more effectively.
Vitamin D improves strength and reduces injuries in dancers, while iron lowers anemia prevalence
Dancers take many supplements, but benefits are often unproven and risks remain unclear
This systematic review of dietary supplement and medication use in 654 female and 86 male professional and pre-professional dancers found vi…
Dancers use many supplements and painkillers, yet benefits are limited and potential health risks need more study before we can trust them.
Commercial preterm formulas with glucose polymers and reduced lactose show higher necrotizing enterocolitis rates than breast milk
Commercial preterm formulas carry higher NEC risk than breast milk
This comprehensive review examines the association between commercial preterm formulas and necrotizing enterocolitis in preterm infants. The…
A review finds commercial preterm formulas with glucose polymers and reduced lactose are linked to higher rates of necrotizing enterocolitis…
Metabolic and bariatric surgery significantly reduces plasma Fetuin-A levels in patients with obesity
Metabolic surgery lowers a blood protein linked to obesity and high sugar
This systematic review and meta-analysis examines plasma Fetuin-A expression and metabolic changes in patients with obesity undergoing metab…
Metabolic surgery significantly reduced a blood protein called Fetuin-A while also lowering BMI and blood sugar in patients with obesity.
Nutrient and metabolite interventions for neurodegenerative diseases show inconsistent clinical translation
Dietary nutrients show mixed results for brain diseases in lab and early human data
This narrative review synthesizes evidence on nutrients and metabolites for Alzheimer's, Parkinson's, multiple sclerosis, and amyotrophic la…
Nutrients like vitamins and marine compounds show promise in labs, but human evidence for brain diseases remains inconsistent and unclear.
Eating later in the biological day is associated with impaired glucose regulation and reduced insulin sensitivity
Eating later in the day is linked to worse blood sugar and heart health markers
This narrative review examines chrononutrition in obesity, type 2 diabetes, hypertension, and cardiovascular disease. Findings indicate that…
A review suggests eating later in the biological day is associated with impaired glucose regulation and reduced insulin sensitivity in peopl…