Review of interferon regulatory factors in ischemia-reperfusion injury across multiple organ systems
Review suggests targeting IRFs may help prevent organ injury from blood flow changes
This review examines regulatory mechanisms and advances regarding interferon regulatory factors (IRFs) in ischemia-reperfusion injury (IRI) …
Targeting interferon regulatory factors offers a new way to prevent severe organ damage when blood flow returns to tissues after a disruptio…
Seasons did not significantly affect pregnancy outcomes in infertile patients undergoing IVF-ET
Does the season change your IVF success? For most pregnancy outcomes, the answer is no
This retrospective cohort study evaluated 1,413 infertile patients undergoing in vitro fertilization-embryo transfer (IVF-ET) to assess seas…
Getting pregnant in spring isn't better than winter for IVF success, as a study of 1,413 patients found no seasonal difference in live birth…
Prenatal depression screening uptake increased but diverged across language groups from 2019 to 2024
Prenatal depression screening rates grew but widened gaps between English and non-English speakers
A retrospective cohort study of 99,526 pregnancies in a U.S.
While prenatal depression screening improved for everyone, English speakers saw bigger gains than Spanish speakers, widening the gap in care…
Cervical blockade reduces pain and bleeding during LEEP for HSIL in small RCT
Local cervical anesthesia reduces pain and bleeding during cervical surgery
A small, open-label RCT of 40 patients with HSIL undergoing LEEP found that adding cervical blockade to general anesthesia significantly red…
Adding local anesthesia to cervical surgery reduced pain and bleeding during the procedure for patients having LEEP to remove abnormal cells…
Mendelian randomization links genetic endometriosis liability to increased placenta praevia risk
Does endometriosis raise pregnancy risks? A genetic link points to one specific danger
A Mendelian randomization meta-analysis using summary-level GWAS data found genetic liability to endometriosis was robustly associated with …
A woman's genetic risk for endometriosis directly increases the chance of placenta praevia, a dangerous condition where the placenta grows t…
HPV cfDNA testing shows high specificity but moderate sensitivity for cervical cancer detection
Blood test for HPV DNA shows promise for monitoring cervical cancer after treatment
A meta-analysis of 20 studies in HPV-positive cervical cancer patients found HPV cfDNA testing had pooled sensitivity of 0.47 and specificit…
A review of 20 studies found that a blood test looking for HPV DNA was very specific for detecting cervical cancer, but it missed about half…
Non-hormonal vaginal moisturizer improves vaginal health indices in postmenopausal breast cancer survivors
Can a simple moisturizer help breast cancer survivors with vaginal discomfort?
An open-label randomized trial in 100 postmenopausal breast cancer survivors with vaginal symptoms found that a non-hormonal vaginal moistur…
A simple non-hormonal moisturizer improved vaginal health scores and tissue pH in breast cancer survivors who finished treatment, offering r…
Phase Ib trial: Mam-A DNA vaccine plus endocrine therapy induces T cells in ER+ breast cancer
Can a breast cancer vaccine help the immune system target tumors?
A phase Ib clinical trial in 21 patients with estrogen receptor-positive breast cancer prior to surgery found that adding Mammaglobin-A DNA …
A breast cancer vaccine triggered specific immune cells to attack tumors in early trial patients, showing promising biological activity befo…
Retrospective cohort finds racial, insurance disparities in cesarean delivery rates
Large U.S. study finds racial and insurance differences in cesarean delivery rates
A retrospective cohort study of 41.5 million singleton live births in the United States (2014-2024) found non-Hispanic Black women had highe…
A massive U.S. study of 41 million births shows Black women and those with private insurance face higher odds of C-sections compared to Whit…
Qualitative study reveals divergent perceptions of hormonal therapy efficacy in endometriosis management
Endometriosis patients and doctors often disagree on what makes treatment effective
A qualitative study of 20 endometriosis patients and 13 healthcare professionals found divergent perceptions of hormonal treatment efficacy.
Endometriosis patients seek pain relief while doctors prioritize stopping periods, creating a communication gap that adds mental burden to b…
PSMA PET/CT shows uptake in half of metastatic triple-negative breast cancer patients
Can a prostate cancer scan help treat aggressive breast cancer?
A prospective single-center study of 20 patients with progressive mTNBC found that 50% showed visual PSMA positivity on [Ga]Ga-PSMA-11 PET/C…
A prostate cancer scan found PSMA targets in half of aggressive breast cancer tumors, suggesting a new therapy option for patients when stan…
RCT compares three teaching strategies for pelvic exam training in medical students
How should medical students learn pelvic exams? A study tests three teaching methods
A randomized trial in 138 medical clerkship students compared three pelvic exam teaching approaches using a simulator.
Watching a patient describe a pelvic exam helped medical students perform better, while a clinical video on a model increased their fear and…