Intrathecal chemotherapy via Ommaya reservoir improves survival in leptomeningeal metastasis
Ommaya reservoirs may help patients with leptomeningeal metastasis live longer than lumbar punctures
This systematic review and meta-analysis of four comparative studies found that intrathecal chemotherapy via Ommaya reservoir was associated…
A new analysis suggests Ommaya reservoirs improve survival and lower side effects for patients with leptomeningeal metastasis compared to lu…
Low pretreatment lymphocyte-to-monocyte ratio linked to worse survival in cervical cancer
Low LMR Linked to Worse Survival in Cervical Cancer Patients
This systematic review and meta-analysis of 5,127 patients found that low pretreatment lymphocyte-to-monocyte ratio (LMR) is associated with…
A low lymphocyte-to-monocyte ratio before treatment predicts poorer survival outcomes for patients with cervical cancer, suggesting a potent…
Lower baseline quality of life linked to 7% higher mortality risk in lung cancer patients
Low quality of life before treatment links to higher death risk in lung cancer patients
This systematic review and meta-analysis of 20,235 lung cancer patients across 18 countries found that lower pre-treatment global quality of…
A large study of 20,235 lung cancer patients found that lower quality of life before treatment was linked to higher mortality risk.
Angiogenesis inhibitors combined with chemotherapy improve progression-free survival in advanced breast cancer patients
Adding angiogenesis inhibitors to chemotherapy helps advanced breast cancer patients stay disease-free longer
This systematic review and meta-analysis of phase II and III trials evaluated angiogenesis inhibitors combined with chemotherapy versus chem…
A large review of eight thousand four hundred patients found that adding angiogenesis inhibitors to standard chemotherapy improved how long …
Mitochondria-targeted strategies show translational potential for improving radiosensitivity in radioresistant tumor cells
Targeting mitochondria may make cancer cells more sensitive to radiation
This narrative review explores mitochondrial-targeted therapeutic strategies for radioresistant tumor cells. The authors discuss various app…
New strategies aim at mitochondria to help radiation kill stubborn cancer cells. Could this change treatment for resistant tumors?
Local radiopharmaceutical production reduces therapy costs by 93% to 96% across 54 African nations
Most African nations lack key cancer therapies, review finds
This systematic review and quantitative infrastructure analysis evaluates radionuclide therapy availability in 54 African nations. Local pro…
Only half of African countries offer I-131 for thyroid cancer; just 7 have Lu-177-PSMA for prostate cancer. Local production could slash cos…
Liver transplantation shows improved five-year survival and recurrence outcomes versus resection for combined hepatocellular-cholangiocarcinoma patients in this meta-analysis
Liver transplant linked to better long-term survival for combined liver cancer
A meta-analysis of six retrospective studies indicates liver transplantation offers superior five-year overall survival and recurrence-free …
A meta-analysis of six studies suggests liver transplantation may offer better long-term survival than resection for a rare combined liver c…
Elevated TRIM47 expression correlates with advanced tumor stage, metastasis, and poor prognosis in cancer
TRIM47 Protein Linked to Cancer Spread and Poor Outcomes
This narrative review assesses the translational feasibility and distinct obstacles of TRIM47-targeted precision nanomedicine. The authors n…
A protein called TRIM47 is tied to advanced cancer and worse survival, but targeting it carries serious risks.
Exercise-induced myokines show functional duality with tumor-suppressive or tumor-promoting effects depending on microenvironmental context
Exercise myokines show complex effects on cancer cells in lab models
This systematic review examines exercise-induced myokines such as IL-6, SPARC, and irisin in cancer. The authors note that these molecules e…
A review of lab studies suggests exercise-linked proteins may suppress or promote cancer depending on the environment, but results are not y…
Partial cystectomy in an 80-year-old woman with small cell carcinoma resulted in death after eight months of follow-up
Rare bladder cancer case in 80-year-old woman ends in death
This case report describes a single 80-year-old woman with small cell carcinoma who underwent partial cystectomy. The patient died after eig…
An 80-year-old woman with a rare bladder cancer died after surgery, highlighting the challenges of diagnosing and treating this disease.
Lenvatinib plus PD-1 inhibitor improves survival versus bevacizumab plus PD-1 inhibitor in unresectable hepatocellular carcinoma
Meta-analysis shows lenvatinib-based regimens improve survival for unresectable liver cancer in East Asia
This systematic review and meta-analysis evaluated first-line treatment for unresectable hepatocellular carcinoma in East Asian populations.
A meta-analysis of East Asian patients with unresectable liver cancer found lenvatinib-based regimens improved survival compared to bevacizu…
Hodgkin lymphoma survival exceeds 90% in early-stage patients with modern therapy
New treatments push Hodgkin lymphoma survival above 90%
This systematic review synthesizes outcomes in Hodgkin lymphoma, reporting 5-year survival exceeding 90% in early-stage patients and long-te…
For early-stage Hodgkin lymphoma, 5-year survival now exceeds 90%. Advanced disease remission tops 75%. But long-term toxicities remain a co…