Ciltacabtagene autoleucel is associated with higher non-ICANS neurologic toxicity rates than idecabtagene vicleucel
Trial shows specific risks for some patients with multiple myeloma
This meta-analysis of 4,630 patients evaluates non-ICANS neurologic toxicities (NINTs) following BCMA-directed CAR-T therapy in multiple mye…
New data reveals that one type of CAR-T cell therapy carries a higher risk of nerve issues than others for patients with multiple myeloma.
Circulating miRNAs show high diagnostic accuracy for oral squamous cell carcinoma with AUC of approximately 0.90
Saliva and blood tests may help identify oral cancer
This systematic review and meta-analysis evaluated the diagnostic accuracy of circulating microRNAs in blood and saliva for oral squamous ce…
New data suggests that specific molecules in saliva and blood could help doctors more accurately identify patients with oral squamous cell c…
Tamoxifen improves distant recurrence-free interval for postmenopausal women with specific tumor microenvironment scores
Tumor environment markers may predict how well tamoxifen works
This secondary analysis of a randomized trial involving 513 postmenopausal women with ER+HER2- breast cancer found that tamoxifen improved t…
New analysis suggests that specific immune and cell types within a tumor could help predict if tamoxifen will be effective for certain breas…
Dostarlimab and Niraparib Combination Improves Progression Free Survival in Advanced Endometrial Cancer
Adding Niraparib to Dostarlimab Delays Endometrial Cancer Worsening
A Phase 3 trial shows that adding niraparib to dostarlimab maintenance significantly extends progression-free survival for patients with adv…
A phase 3 trial found that adding niraparib to dostarlimab after chemo slowed cancer growth in advanced endometrial cancer, but did not exte…
Preconsult digital Patient Decision Aids reduce decisional conflict before consultation in breast cancer patients
Digital tools may lower decision stress for breast cancer patients
This randomized controlled trial of 204 patients with breast cancer found that a preconsult digital Patient Decision Aid (PtDA) significantl…
A new study shows that digital tools can help breast cancer patients feel less conflicted about their treatment choices before meeting with …
CaDC escalating to CBT-PTSD produces largest effects for PTSD symptoms in HCT survivors
New trial shows stepped care helps heart transplant survivors
This Sequential Multiple Assignment Randomized Trial of 477 HCT survivors found that adaptive treatment sequences escalating to CBT-PTSD res…
A new study finds that a two-step treatment plan can help heart transplant survivors manage symptoms of PTSD and anxiety.
First-line immune checkpoint inhibitor combinations improve overall survival in extensive-stage small-cell lung cancer
Immune checkpoint inhibitors combined with chemotherapy improve small cell lung cancer survival
This meta-analysis of 3,910 patients with extensive-stage small-cell lung cancer (ES-SCLC) found that first-line immune checkpoint inhibitor…
Combining immune checkpoint inhibitors with chemotherapy shows better survival rates for patients with extensive stage small cell lung cance…
Ropeginterferon alfa-2b shows significant benefit over phlebotomy for complete hematologic response in polycythemia vera
Ropeginterferon alfa-2b shows better results than phlebotomy for PV
This meta-analysis of 522 patients with polycythemia vera found that ropeginterferon alfa-2b provides a statistically significant advantage …
A new analysis shows that ropeginterferon alfa-2b may offer better long-term management for polycythemia vera patients compared to standard …
Pirtobrutinib Combined with Venetoclax and Rituximab Improves Progression Free Survival
Trial shows pirtobrutinib improves survival for chronic lymphocytic leukemia
Adding pirtobrutinib to a venetoclax-rituximab regimen significantly extends progression-free survival in patients with chronic lymphocytic …
A new combination treatment involving pirtobrutinib may help patients with chronic lymphocytic leukemia live longer without their cancer pro…
Chest wall radiotherapy results in worse chest wall symptoms but no other quality of life impacts
Trial shows chest wall radiotherapy affects symptoms in breast cancer
This Phase 3 randomized controlled trial evaluated the impact of chest wall radiotherapy on quality of life (QOL) in women with intermediate…
New trial data reveals that while chest wall radiation may cause more local symptoms, it does not impact other quality of life factors for p…
Liquid biopsy-derived multimodal models outperform CT-based evaluation for pulmonary nodule diagnosis
Liquid biopsy models show better results for lung nodule diagnosis
This systematic review and meta-analysis evaluates the diagnostic performance of liquid biopsy-derived multimodal models compared to traditi…
New data shows that combining liquid biopsies with other tests helps doctors identify cancer in lung nodules more accurately than standard C…
Dose-dense adjuvant chemotherapy reduces invasive disease hazard by 38% in HER2-zero breast cancer
Dose-dense Chemotherapy Shows Benefit for Early Stage Breast Cancer
This exploratory analysis of a randomized controlled trial involving 1243 patients with node-positive early-stage HER2-negative breast cance…
A large study suggests that a dose-dense chemotherapy schedule may improve survival and outcomes for patients with HER2-negative breast canc…