Multi-parameter models of inhibitory receptor states could better predict immunotherapy response and toxicity
New Framework Could Improve Cancer Immunotherapy Safety
This narrative review explores the use of inhibitory receptors as dynamic readouts for identifying therapeutic windows in cancer immunothera…
A new review suggests tracking immune receptor states could better predict cancer treatment side effects and effectiveness.
Pancreaticoduodenectomy for unclassified duodenal spindle cell tumor shows no recurrence by May 2025
A rare abdominal tumor shows no signs of returning
This case report describes a 55-year-old woman with an unclassified duodenal mesenchymal spindle cell tumor treated with pancreaticoduodenec…
A woman with a rare intestinal tumor showed no signs of cancer spreading after surgery, highlighting the risks of incomplete initial tests.
Laparoscopic-endoscopic cooperative full-thickness resection achieves pT3 excision with no recurrence at 21 months
New technique removes colon cancer without cutting open the abdomen
This case report describes a 61-year-old man with a history of rectal cancer surgery who underwent laparoscopic-endoscopic cooperative full-…
A 61-year-old man's recurrent colon cancer was removed through a scope, no scars, no recurrence at 21 months.
Ion channels and signaling pathways form a mechanobiological-immunological framework for osteoarthritis progression
New Framework Links Ion Channels to Osteoarthritis
This narrative review synthesizes the roles of ion channels and key signaling pathways in osteoarthritis pathology. It proposes an integrate…
A new review maps how ion channels and signaling pathways interact in osteoarthritis, offering a theoretical basis for future multi-target t…
Natural polysaccharides combined with immune checkpoint inhibitors show synergistic benefits in preclinical and early clinical observations
Natural sugars may help patients whose cancer resists immune drugs
This systematic review examines the use of natural polysaccharides as immune adjuvants for patients with solid tumors resistant to immune ch…
New research explores how natural polysaccharides can help boost the effectiveness of immunotherapy for patients with advanced solid tumors.
Trop-2 directed ADCs improve progression free survival in high Trop-2 expression breast cancer patients
Trop-2 Protein Levels May Influence Breast Cancer Treatment Outcomes
This meta-analysis and retrospective analysis evaluate the impact of Trop-2 protein and gene expression on outcomes for patients with breast…
New analysis suggests Trop-2 protein levels may help predict how patients with breast cancer respond to specific antibody-drug conjugate tre…
Chemokine networks regulate triple-negative breast cancer tumor microenvironment but clinical translation remains limited
Chemokine Targets Show Promise in Lab but Face Clinical Hurdles
This systematic review examines the role of chemokine networks and targeted interventions in the triple-negative breast cancer immune microe…
New research highlights the role of chemokine networks in breast cancer, showing strong results in labs despite challenges in current clinic…
Scoping review protocol maps technology and barriers to cervical cancer screening uptake
New Plan to Use Technology for Cervical Cancer Screening
This scoping review protocol outlines a planned synthesis of evidence on technological interventions, knowledge, and barriers affecting cerv…
A new research plan aims to use mobile health and telemedicine tools to help more women find out about and access cervical cancer screenings…
Complete surgical excision of renal solitary fibrous tumors is associated with favorable clinical outcomes
Surgical Removal Shows Favorable Outcomes for Renal Solitary Fibrous Tumors
This narrative review synthesizes the management and histopathology of primary renal solitary fibrous tumors. The authors conclude that comp…
Complete surgical removal and long-term monitoring are key strategies for managing renal solitary fibrous tumors, which can recur even after…
Myoepithelial carcinoma of gallbladder shows irregular wall thickening and progressive enhancement
Radiological Features Help Identify Rare Myoepithelial Carcinoma of the Gallbladder
This case report and literature review describes a 57-year-old male with primary myoepithelial carcinoma of the gallbladder, highlighting ra…
New findings highlight specific imaging signs like irregular wall thickening to help doctors identify a rare type of gallbladder cancer.
Advanced-stage NSCLC patients show higher objective response rates than early-stage patients on EGFR-TKI monotherapy
EGFR-TKIs Work Differently by Lung Cancer Stage
This meta-analysis of 3713 patients compared the efficacy and safety of EGFR-TKIs in early-stage versus advanced-stage non-small cell lung c…
Advanced lung cancer responds better to EGFR-TKIs, but early-stage has fewer side effects. New analysis of 3,713 patients shows stage matter…
New-onset diabetes and preoperative hyperglycemia predict worse survival in pancreatic ductal adenocarcinoma
Metformin use linked to better survival in pancreatic cancer
This meta-analysis of cohort studies evaluates the impact of glycemic status and metformin use on overall survival in patients with pancreat…
New research shows that patients with pancreatic cancer taking metformin may have a lower risk of death compared to those who do not.