Elevated pretreatment pan-immune-inflammation value correlates with worse survival outcomes in patients treated with immune checkpoint inhibitors
High inflammation levels may signal poorer survival for cancer patients
This systematic review and meta-analysis of 3,272 participants across 28 cohorts found that elevated pretreatment PIV is associated with sho…
A new look at cancer data suggests that high inflammation scores before treatment can predict shorter survival for those using immune checkp…
Olopatadine and mizolastine are more effective than placebo for total symptom scores in chronic urticaria
Specific Antihistamines Show Different Success Rates for Chronic Urticaria
This network meta-analysis of 54 studies involving 7,290 patients evaluated 10 second-generation H1 antihistamines for chronic urticaria. Th…
Different antihistamines may offer varying levels of relief for itching and skin welts in patients with chronic urticaria.
Higher preoperative systemic immune-inflammation index is associated with reduced overall survival in bladder cancer
Higher Immune Inflammation Index Linked to Poorer Bladder Cancer Survival
This meta-analysis of 6,288 patients identifies a significant association between higher preoperative systemic immune-inflammation index (SI…
A high immune-inflammation index may signal a poorer outlook for patients undergoing surgery for bladder cancer.
Endoscopic full-thickness resection reduces perforation risk and procedure time compared to endoscopic submucosal dissection
Trial shows EFTR reduces risks for certain colorectal lesions
This systematic review and meta-analysis of 5 studies involving 570 patients found that endoscopic full-thickness resection (EFTR) significa…
A new analysis suggests that the EFTR technique may lower perforation risks and procedure times when treating specific types of colorectal l…
Targeted therapy plus chemotherapy improves objective response and disease control rates in advanced TNBC
Targeted therapy plus chemotherapy improves response in triple-negative breast cancer
This systematic review and meta-analysis of 523 patients found that adding targeted therapy to chemotherapy for advanced triple-negative bre…
Adding targeted therapy to chemotherapy may improve how tumors respond in patients with advanced triple-negative breast cancer.
Adjuvant CDK4/6 inhibitors improve invasive Disease-Free Survival regardless of patient menopausal status
CDK4/6 inhibitors show consistent results for both pre and postmenopausal women
This meta-analysis of 17,748 patients with HR+ and HER2-negative early breast cancer found that adjuvant CDK4/6 inhibitors improved invasive…
New data suggests that a specific type of breast cancer treatment works effectively regardless of whether a patient has reached menopause.
Clinician-guided action plans and lifestyle coaching aim to improve sedentary time in childhood cancer survivors
New plan to improve heart health in childhood cancer survivors
This randomized controlled trial protocol describes an intervention for 374 childhood cancer survivors at risk of cardiovascular disease. Th…
A new clinical trial is testing if personalized coaching and mobile tools can help childhood cancer survivors improve their diet and activit…
Mefatinib improves median IRC-assessed progression-free survival to 13.7 months versus 9.7 months for gefitinib
Trial shows mefatinib improves progression-free survival in lung cancer
This Phase III randomized trial of 336 patients with advanced nonsquamous NSCLC harboring EGFR L858R or exon 19 deletion found mefatinib (60…
A Phase III trial found that mefatinib may extend progression-free survival for patients with specific types of advanced non-small cell lung…
Lung cancer risk models show moderate to excellent discrimination, but few are ready for clinical use
Lung Cancer Risk Models Show Promise, Need Validation
This systematic review and meta-regression of 91 risk prediction models for lung cancer screening selection and nodule classification found …
New review finds lung cancer risk models perform well, but most need more testing before clinical use.
Structured assessment and short-term crisis stabilization are key for managing BPD in emergency settings
Emergency care for borderline personality disorder: what works
This scoping review examines emergency psychiatric assessment, disposition decisions, and acute management strategies for adults with border…
A new review finds brief crisis stays and structured suicide checks may help people with BPD in the ER, not long hospitalizations.
Trastuzumab deruxtecan shows limited efficacy in HER2-positive breast squamous cell carcinoma following standard therapy failure
New Treatment Options for Rare HER2-Positive Breast Squamous Cell Carcinoma
This case report and literature review examines the management of a patient with HER2-positive primary breast squamous cell carcinoma. The a…
A rare form of breast cancer may respond differently to standard treatments, highlighting the need for personalized medicine based on specif…
Reduced-port robotic surgery offers comparable perioperative outcomes to multiport surgery in endometrial cancer
Reduced-Port Robotic Surgery Shows Similar Safety for Endometrial Cancer
This meta-analysis of 905 patients compares reduced-port and multiport robotic surgery for endometrial cancer. The analysis found no signifi…
Reduced-port robotic surgery shows similar safety and recovery times compared to multiport methods for patients with endometrial cancer.