LP-184 Alone and With Spironolactone in Recurrent Glioblastoma: Phase 1a Results
New drug combo may help brain cancer patients who have run out of options
This Phase 1a trial in 63 patients (16 with glioblastoma) found LP-184 was well tolerated but with more transaminitis and thrombocytopenia i…
A new drug combination could help brain cancer patients by making their current medicine work much harder inside the tumor.
Modified Banxia Xiexin Decoction plus chemotherapy shows favorable trends in advanced colorectal cancer
Modified herbal decoction may extend survival time for advanced colorectal cancer patients
This randomized controlled trial in 129 patients with advanced colorectal cancer evaluated modified Banxia Xiexin Decoction (mBXD) granules …
Adding a modified herbal decoction to standard cancer treatment might extend survival time and reduce tumor growth in patients with advanced…
Camrelizumab plus nab-paclitaxel showed modest activity in previously treated advanced urothelial carcinoma patients
New Treatment Extends Life for Bladder Cancer Patients
This multicenter Phase II study evaluated camrelizumab plus nab-paclitaxel in 60 patients with advanced urothelial carcinoma who progressed …
For years, Mark, 64, thought he’d beaten cancer.
Colonoscopic Surveillance in Lynch Syndrome Linked to Lower Mortality but Not Reduced Cancer Incidence
Colonoscopies Save Lives in High-Risk Patients
This observational cohort study of 4732 MMR-carriers in the English NHS found that colonoscopic surveillance was associated with decreased C…
You’ve just turned 35. Your mom had colon cancer at 42.
Pembrolizumab adjuvant therapy trial for hepatocellular carcinoma recurrence-free survival
Pembrolizumab May Cut Liver Cancer Return After Surgery
This is a Phase 3 randomized controlled trial in 959 participants with hepatocellular carcinoma who had a complete radiological response aft…
After liver surgery, pembrolizumab may help keep hepatocellular carcinoma from returning, offering new hope for patients with complete tumor…
Narrative review suggests CXCR4 antagonists may target metastatic colorectal cancer via the CXCL12/CXCR4 axis
New review suggests blocking a specific pathway may help fight colorectal cancer spread
This narrative review examines the potential of CXCR4 antagonists, specifically plerixafor and LY2510924, in treating metastatic colorectal …
A fresh look at colorectal cancer shows blocking a specific chemical pathway might stop tumors from spreading and help immune drugs work bet…
Review discusses aptamers and aptamer-drug conjugates for cancer without reported outcomes or safety data
Review of aptamers and aptamer-drug conjugates for cancer treatment
This narrative review examines the use of aptamers and aptamer-drug conjugates in cancer treatment.
A review examines how aptamers and aptamer-drug conjugates may help treat cancer, though details on specific results and patient groups were…
Histology-derived gene-expression signatures predict distant recurrence-free interval and chemotherapy benefit in early breast cancer cohorts
New Tool Predicts Breast Cancer Recurrence From Old Slides
This multi-cohort study evaluated histology-derived gene-expression signatures from routine hematoxylin and eosin slides compared with clini…
A simple AI analysis of old biopsy slides can now predict which breast cancer patients face higher risk of recurrence and who truly benefits…
Baseline Cytokine Levels Linked to Placebo Response in Cancer Dyspnea Trial
High Inflammation Might Reduce Placebo Effect in Cancer
This exploratory analysis of an RCT in 45 cancer patients with dyspnea found a negative association between baseline cytokine levels and sym…
Scientists found that high inflammation levels may stop the placebo effect from working well.
Narrative review discusses adapter-based CAR T cells for solid tumors and hematological malignancies
Adapter-based CAR T cells face hurdles in treating solid tumors and blood cancers
This narrative review examines the potential of adapter-based CAR T cells across multiple cancer types, including solid tumors and hematolog…
A review highlights that making these cells is hard work and they struggle against solid tumors, limiting their current use.
Ultrasound radiomics features aid preoperative differentiation of granulomatous lobular mastitis and breast cancer in a retrospective cohort
Ultrasound Can Spot This Breast Condition Before Surgery
This retrospective cohort study evaluated ultrasound radiomics features in 237 patients with granulomatous lobular mastitis or breast cancer…
Many women face a scary moment when a lump appears in their breast.
Tisagenlecleucel in Korean patients with relapsed or refractory diffuse large B-cell lymphoma
New Lymphoma Therapy Helps Patients Live Longer
This retrospective cohort study of 79 Korean patients with relapsed or refractory diffuse large B-cell lymphoma evaluated tisagenlecleucel.
A new study shows a specific immune therapy can shrink tumors and extend life for lymphoma patients who have run out of options.