SDHD Variant Carriers Face High Penetrance and Multifocal Tumors
SDHD Genetic Variants Linked to Increasing Risk of Tumors Over Time
A meta-analysis of SDHD pathogenic variant carriers reveals age-specific penetrance rising to 82% by age 60, with 75% developing multifocal …
New data shows that the risk of developing tumors increases significantly with age for people carrying specific SDHD genetic variants.
Successful radiation oncology AI integration requires trustworthy ecosystems and human-centered workflow design
Factors Influencing Success of Artificial Intelligence in Radiation Oncology
This narrative review examines the role of artificial intelligence in radiation oncology workflows. The authors argue that clinical success …
Successful use of artificial intelligence in radiation oncology depends on creating trustworthy systems that integrate with human expertise …
Endoscopic resection followed by esophagectomy shows favorable recurrence-free and disease-specific survival in superficial esophageal cancer
Combined endoscopic surgery and esophagectomy may improve cancer outcomes
This systematic review and network meta-analysis of 2,621 patients with high-risk superficial esophageal cancer found that endoscopic resect…
A new analysis suggests that combining endoscopic resection with surgery could help patients with high-risk esophageal cancer live longer wi…
Comparative Efficacy of Immunotherapy Combinations in Advanced Renal Cell Carcinoma Management
New analysis compares immunotherapy combinations for advanced renal cell carcinoma
A network meta-analysis evaluates diverse immunotherapy combinations for advanced renal cell carcinoma, highlighting specific survival benef…
A large review of over 6,000 patients identifies specific immunotherapy combinations that may improve survival for those with advanced kidne…
Bibliometric Analysis Maps Paraptosis Research Landscape in Cancer
Mapping the Research Landscape of Paraptosis in Cancer Treatment
A bibliometric analysis of 401 publications reveals rising interest in paraptosis, a non-apoptotic cell death pathway, with China and Ajou U…
A review of 401 publications shows a significant rise in research on paraptosis, a specific type of cell death that may impact cancer treatm…
Oral propranolol remains the primary systemic treatment for infantile hemangioma with no superior alternatives
Propranolol Remains the Standard Treatment for Infantile Hemangioma
This meta-analysis of 2639 patients found that no active intervention, including corticosteroids or other beta-blockers, demonstrated statis…
A review of over 2,600 cases shows that while several drugs treat infantile hemangioma, oral propranolol remains a primary standard.
Immune checkpoint inhibitors plus chemotherapy improve overall survival in advanced triple-negative breast cancer
Immunotherapy plus chemo improves survival in triple-negative breast cancer
This umbrella meta-analysis of 39,147 patients found that combining immune checkpoint inhibitors with chemotherapy significantly improves ov…
Adding immunotherapy to chemo helps some patients with advanced triple-negative breast cancer live longer, but side effects are more common.
HPV shows strong association with oropharyngeal SCC while other oncogenic viruses show limited evidence
Viruses linked to oral and throat cancers in new review
This systematic review examines the role of various oncogenic viruses in oral and oropharyngeal squamous cell carcinomas. It identifies a co…
A strong link between HPV and throat cancer is confirmed, while other viruses show less clear evidence of causing cancer.
Soluble CD146 serves as a marker of microvascular stress and promotes tumor invasion
Soluble CD146 May Help Identify Cancer and Heart Stress
This systematic review examines the role of soluble CD146 (sCD146) in malignant solid tumors and cardiovascular diseases. The authors conclu…
A protein called sCD146 may help doctors identify cancer cell behavior and track stress in heart and lung tissues.
Evidence-based guidelines support team-based perioperative glycemic management for patients with hepatocellular carcinoma
New guidance for blood sugar control before liver cancer surgery
This evidence summary synthesizes 14 documents, including guidelines and randomized controlled trials, to provide guidance on perioperative …
A new evidence summary offers 28 best practice items for managing blood sugar in liver cancer patients before, during, and after surgery.
CXCL16/CXCR6 axis exerts bidirectional regulatory influence on neoplasms and inflammatory disorders like asthma
New Biological Pathways May Help Doctors Treat Cancer and Asthma Better
This narrative review examines the CXCL16/CXCR6 axis as a multifaceted regulator in various pathological processes, including neoplasms and …
Scientists are looking at how a specific protein pathway can influence both cancer growth and lung inflammation.
FDA Approves Ogsiveo (nirogacestat) for Progressing Desmoid Tumors
FDA approves Ogsiveo, first drug for rare desmoid tumors
FDA approved Ogsiveo for adult patients with progressing desmoid tumors who require systemic treatment. Approval based on DeFi trial showing…
The FDA approved Ogsiveo (nirogacestat) for adults with progressing desmoid tumors who need systemic treatment. This is the first drug speci…