Phase 2 trial of pembrolizumab and DNA vaccines in metastatic prostate cancer shows no significant difference
Prostate Cancer Vaccine Strategy Shows Tumor Responses, But One Arm Adds Risk
This early Phase 2 trial evaluated pembrolizumab combined with pTVG-HP or pTVG-AR DNA vaccines in 60 patients with metastatic castration-res…
A two-vaccine strategy did not improve survival over a single vaccine in advanced prostate cancer, yet both approaches shrank tumors in some…
Double 8F ultrafine chest tubes reduced pain and complications compared to standard tubes in lung tumor patients.
Smaller tubes mean less pain for lung tumor patients after surgery.
This retrospective multicenter cohort study evaluated 1,076 lung tumor patients who underwent U-VATS. The double 8F ultrafine chest tube gro…
Lung surgery patients feel significantly less pain and face lower bleeding risks when doctors use ultrafine drainage tubes instead of regula…
LP-184 Alone and With Spironolactone in Recurrent Glioblastoma: Phase 1a Results
New drug combo may help brain cancer patients who have run out of options
This Phase 1a trial in 63 patients (16 with glioblastoma) found LP-184 was well tolerated but with more transaminitis and thrombocytopenia i…
A new drug combination could help brain cancer patients by making their current medicine work much harder inside the tumor.
Modified Banxia Xiexin Decoction plus chemotherapy shows favorable trends in advanced colorectal cancer.
Modified herbal decoction may extend survival time for advanced colorectal cancer patients
This randomized controlled trial in 129 patients with advanced colorectal cancer evaluated modified Banxia Xiexin Decoction (mBXD) granules …
Adding a modified herbal decoction to standard cancer treatment might extend survival time and reduce tumor growth in patients with advanced…
Camrelizumab plus nab-paclitaxel showed modest activity in previously treated advanced urothelial carcinoma patients.
New Treatment Extends Life for Bladder Cancer Patients
This multicenter Phase II study evaluated camrelizumab plus nab-paclitaxel in 60 patients with advanced urothelial carcinoma who progressed …
For years, Mark, 64, thought he’d beaten cancer.
Colonoscopic Surveillance in Lynch Syndrome Linked to Lower Mortality but Not Reduced Cancer Incidence
Colonoscopies Save Lives in High-Risk Patients
This observational cohort study of 4732 MMR-carriers in the English NHS found that colonoscopic surveillance was associated with decreased C…
You’ve just turned 35. Your mom had colon cancer at 42.
Pembrolizumab adjuvant therapy trial for hepatocellular carcinoma recurrence-free survival
Pembrolizumab May Cut Liver Cancer Return After Surgery
This is a Phase 3 randomized controlled trial in 959 participants with hepatocellular carcinoma who had a complete radiological response aft…
After liver surgery, pembrolizumab may help keep hepatocellular carcinoma from returning, offering new hope for patients with complete tumor…
Narrative review suggests CXCR4 antagonists may target metastatic colorectal cancer via the CXCL12/CXCR4 axis.
New review suggests blocking a specific pathway may help fight colorectal cancer spread
This narrative review examines the potential of CXCR4 antagonists, specifically plerixafor and LY2510924, in treating metastatic colorectal …
A fresh look at colorectal cancer shows blocking a specific chemical pathway might stop tumors from spreading and help immune drugs work bet…
Review discusses aptamers and aptamer-drug conjugates for cancer without reported outcomes or safety data.
Review of aptamers and aptamer-drug conjugates for cancer treatment
This narrative review examines the use of aptamers and aptamer-drug conjugates in cancer treatment. The authors note that key details regard…
A review examines how aptamers and aptamer-drug conjugates may help treat cancer, though details on specific results and patient groups were…
Histology-derived gene-expression signatures predict distant recurrence-free interval and chemotherapy benefit in early breast cancer cohorts.
New Tool Predicts Breast Cancer Recurrence From Old Slides
This multi-cohort study evaluated histology-derived gene-expression signatures from routine hematoxylin and eosin slides compared with clini…
A simple AI analysis of old biopsy slides can now predict which breast cancer patients face higher risk of recurrence and who truly benefits…
Baseline Cytokine Levels Linked to Placebo Response in Cancer Dyspnea Trial
High Inflammation Might Reduce Placebo Effect in Cancer
This exploratory analysis of an RCT in 45 cancer patients with dyspnea found a negative association between baseline cytokine levels and sym…
Scientists found that high inflammation levels may stop the placebo effect from working well.
Combination immunotherapy and targeted therapy regimens show favorable survival outcomes versus monotherapies in unresectable hepatocellular carcinoma.
New Data Reveals Which Liver Cancer Treatments Work Best Over Time
This systematic review and pooled analysis of parametric survival curves from 15 randomized controlled trials evaluated first-line treatment…
This research shows that combining two different cancer drugs helps patients live longer than using just one, but the benefit isn't constant…