Paclitaxel arm achieves 56.4% pathologic complete response compared to 23.7% with endocrine therapy
Trial shows chemotherapy helps shrink early breast cancer more effectively
This Phase II multicenter randomized trial evaluated neoadjuvant trastuzumab and pertuzumab combined with either endocrine therapy or paclit…
A new trial compares using standard chemotherapy versus hormone therapy to shrink tumors before surgery in patients with HER2-positive breas…
Multifaceted preventive nursing program reduces fall incidence from 19.8% to 7.1% in elderly NHL patients
Nursing Program Reduces Fall Risk for Lymphoma Patients
This randomized controlled trial of 210 older adults with non-Hodgkin's lymphoma found that a multifaceted preventive nursing program signif…
A specialized nursing program significantly reduced falls and improved mobility for older adults undergoing chemotherapy for lymphoma.
5-ALA PDT improves overall response and HPV clearance in cervical squamous intraepithelial lesions
Photodynamic therapy shows promise for cervical squamous intraepithelial lesions
This meta-analysis of 3,354 patients evaluated 5-aminolevulinic acid photodynamic therapy (5-ALA PDT) for cervical squamous intraepithelial …
A new treatment method using light and a specific compound may improve response rates and clear HPV infections in patients with cervical les…
Multimodal fusion and radiogenomic frameworks show promise for capturing heterogeneity in triple-negative breast cancer
Artificial Intelligence Shows Promise in Triple-Negative Breast Cancer Care
This narrative synthesis reviews the application of artificial intelligence across radiology, digital pathology, and multi-omics for triple-…
New research shows how artificial intelligence can help identify cancer subtypes and predict treatment responses for patients with triple-ne…
Problem-focused coping is moderately to strongly associated with benefit finding in adult cancer patients
Specific coping strategies may help cancer patients find meaning
This meta-analysis of 6078 adult cancer patients found that problem-focused coping was moderately to strongly associated with benefit findin…
New data shows that focusing on practical problems and positive emotions can help people with cancer find more benefit in their lives.
Endoscopic transsphenoidal surgery increases gross total resection rates for pituitary tumors compared to microscopic techniques
Endoscopic surgery shows higher removal rates for pituitary tumors
This meta-analysis of 26,295 patients compares endoscopic and microscopic transsphenoidal pituitary surgery. The analysis found higher rates…
Doctors find that endoscopic surgery helps remove more of a pituitary tumor while keeping the same level of safety as traditional methods.
Surgical treatment and multimodal therapies characterize management options for rare penile melanoma cases
Treatment Options and Clinical Features for Penile Melanoma
This case series and narrative review describes the clinical features and treatment landscape for patients with penile melanoma. The authors…
New research highlights surgical options and targeted therapies for penile melanoma, a rare form of skin cancer that primarily affects middl…
HR-positive HER2-low breast cancer accounts for 60% of cases; deruxtecan reshapes treatment
New drug class reshapes treatment for common breast cancer type
This systematic review examines HR-positive HER2-low-expressing breast cancer, noting it accounts for nearly 60% of breast cancer incidence.…
Nearly 60% of breast cancers are HR-positive HER2-low. A new drug class is changing how they're treated.
Indefinite-duration lenalidomide maintenance shows no significant difference in overall survival compared to fixed-duration
Trial compares continuous versus fixed duration lenalidomide for myeloma
This Phase 3 randomized trial of 516 patients with standard-risk newly diagnosed multiple myeloma found that indefinite-duration lenalidomid…
A large trial found that continuing lenalidomide treatment indefinitely did not improve overall survival compared to a fixed two-year plan.
AI plus celecoxib more than doubles odds of clinical response in ER-positive breast cancer
Adding celecoxib to hormone therapy improves early breast cancer response
This Phase III randomized trial of 269 postmenopausal women with ER-positive resectable breast cancer found that adding celecoxib to an arom…
A new trial shows that adding the drug celecoxib to standard hormone therapy can improve initial clinical responses in postmenopausal women …
BIRC3::MALT1 fusion detected in 35% of cells in pulmonary MALT lymphoma case
Case Report Shows Pulmonary MALT Lymphoma Diagnosis in Lung Nodule
This case report describes a 49-year-old man with pulmonary MALT lymphoma and a BIRC3::MALT1 fusion. The report highlights that mild FDG upt…
A rare type of lymphoma was identified in a 49-year-old man, highlighting the importance of tissue samples when interpreting imaging results…
Artificial intelligence improves diagnostic accuracy and treatment planning in prostate cancer management
Artificial Intelligence Shows Potential for Prostate Cancer Diagnosis and Treatment
This narrative review examines the role of artificial intelligence in diagnosing and treating prostate cancer. The authors conclude that AI-…
New research explores how artificial intelligence can improve the accuracy of prostate cancer diagnosis and help create more personalized tr…