FDA Approves Padcev (enfortumab vedotin) for Muscle Invasive Bladder Cancer
FDA approves Padcev combination for bladder cancer before and after surgery
FDA approved Padcev (enfortumab vedotin) in combination with pembrolizumab as neoadjuvant and adjuvant treatment for adult patients with mus…
The FDA approved Padcev with pembrolizumab for muscle invasive bladder cancer before and after surgery in patients who cannot take cisplatin…
Post-diagnosis physical activity of 7.5 MET-hr/week associated with lower all-cause mortality in prostate cancer
Higher physical activity linked to lower death rates in prostate cancer
This meta-analysis of 10 studies involving over 50,144 men with prostate cancer found that higher levels of post-diagnosis physical activity…
Men with prostate cancer who stay active after diagnosis may have a lower risk of death from all causes.
Comparative Efficacy of PD-1 and PD-L1 Inhibitors in Advanced Non-Small Cell Lung Cancer
Analysis shows PD-1 inhibitors may outperform PD-L1 for lung cancer
A meta-analysis suggests that PD-1 inhibitors combined with chemotherapy offer superior survival outcomes compared to PD-L1 inhibitors plus …
A large analysis of over 14,000 patients suggests that certain types of immunotherapy combined with chemotherapy may offer better survival r…
Axicabtagene ciloleucel shows higher early response but greater toxicity than tisagenlecleucel in large B-cell lymphoma
Comparison of two CAR-T cell therapies for lymphoma
This meta-analysis compared axicabtagene ciloleucel and tisagenlecleucel for the treatment of large B-cell lymphoma. While axicabtagene cilo…
New data comparing axicabtagene ciloleucel and tisagenlecleucel shows different levels of early response and safety risks for lymphoma patie…
EUS-HGAS provides longer time to recurrent biliary obstruction than EUS-HGS in malignant biliary obstruction
New data shows specific stent placement lasts longer for bile blockages
This meta-analysis of individual patient data analyzed 451 patients with malignant biliary obstruction following failed ERCP. The analysis f…
A new analysis reveals that adding an antegrade stent can significantly delay the return of blocked bile flow in certain cancer patients.
Neoadjuvant gemcitabine plus nab-paclitaxel vs gemcitabine plus S-1 for geriatric pancreatic cancer
Trial tests two chemo combos for older pancreatic cancer patients
This Phase III randomized controlled trial is evaluating neoadjuvant gemcitabine plus nab-paclitaxel compared to gemcitabine plus S-1 in 400…
A new trial compares two chemotherapy combinations for older adults with resectable pancreatic cancer.
Transcriptome-wide meta-analysis identifies over 1,095 differentially expressed genes in vestibular schwannoma
Gene Analysis Identifies Potential Targets for Vestibular Schwannoma
This meta-analysis of four independent microarray datasets identifies more than 3,200 genes and 1,095 significantly differentially expressed…
A large-scale gene analysis identifies over 1,000 specific genes linked to vestibular schwannoma that may offer new paths for future treatme…
Hangeshashinto may reduce oral mucositis risk in chemotherapy patients (RR 0.86)
Japanese herbal rinse may reduce mouth sores from chemo
This meta-analysis of 5 RCTs and 1 case-matched study (293 patients) found that hangeshashinto was associated with a reduced risk of chemoth…
A Japanese herbal mouth rinse may help prevent painful mouth sores in people getting chemotherapy for cancer.
Omics-guided surgical paradigms may identify specific patients for selective retroperitoneal clearance in advanced ovarian cancer
New Surgical Approach May Reduce Risks for Ovarian Cancer Patients
This systematic review examines the role of omics-guided surgery versus routine lymphadenectomy in advanced epithelial ovarian cancer. The a…
A new surgical model aims to reduce complications and identify specific patients who may benefit from targeted treatments for advanced ovari…
0.018-inch and 0.022-inch bracket slots show no clinically relevant differences in orthodontic outcomes
Comparing 0.018 and 0.022 Bracket Sizes for Orthodontic Treatment
This systematic review of 9 RCTs compared 0.018-inch and 0.022-inch bracket slot sizes for dentofacial malocclusion treatment. The authors f…
Choosing between 0.018 and 0.022 bracket sizes may not change the final quality or duration of your orthodontic treatment.
Synergistic Effects of Immune Checkpoint Inhibitors and Radiotherapy in Solid Tumor Management
Combining immune checkpoint inhibitors and radiotherapy improves survival outcomes
Meta-analysis data indicates that combining immune checkpoint inhibitors with radiotherapy significantly improves survival outcomes in solid…
New data shows that adding immune checkpoint inhibitors to radiation therapy can improve survival for patients with many types of solid tumo…
High tumour-associated neutrophils at the invasive margin are associated with improved overall survival
Neutrophils at Tumor Edge Linked to Better Colon Cancer Survival
This meta-analysis of 7,406 patients with stages I-IV colorectal cancer found that high tumour-associated neutrophils (TANs) at the invasive…
A new meta-analysis finds that high levels of certain immune cells at the tumor's edge are linked to better survival in colorectal cancer pa…