Multifaceted mechanisms including replication fork stabilization and epigenetic reprogramming drive PARP inhibitor resistance in ovarian cancer
New Strategies May Help Overcome Ovarian Cancer Treatment Resistance
This narrative review explores the mechanisms of resistance to PARP inhibitors in patients with advanced epithelial ovarian cancer. The auth…
Researchers are identifying specific biological mechanisms that cause ovarian cancer to resist PARP inhibitors, opening doors for new treatm…
Metabolic reprogramming of macrophages drives pro-fibrotic polarization in patients with Idiopathic Pulmonary Fibrosis
Metabolic changes in immune cells drive lung scarring in IPF
This systematic review examines the role of macrophage metabolism in Idiopathic Pulmonary Fibrosis. The authors synthesize evidence that glu…
New research identifies how changes in how immune cells process nutrients drive the scarring of lungs in patients with Idiopathic Pulmonary …
SGRT and OSMS assisted DIBH reduces heart and LAD doses in left-sided breast radiotherapy
Surface Guided Radiotherapy May Lower Heart Dose in Breast Cancer
This systematic review and meta-analysis of 52 studies indicates that SGRT or OSMS assisted DIBH is associated with lower heart, LAD, and ip…
New analysis suggests that using surface-guided monitoring during radiation for left-sided breast cancer may reduce doses to the heart and l…
TMB and TILs show no clear association with second primary cancer in resected NSCLC
Tumor Markers May Link to Survival in Lung Cancer Patients
This meta-analysis of three randomized trials evaluated the association between tumor mutational burden (TMB), tumor-infiltrating lymphocyte…
New analysis of lung cancer data suggests that specific tumor markers and immune cell levels may relate to patient survival rates.
Psychological, social, and behavioral barriers and facilitators influence prehabilitation adherence in cancer patients before surgery
Identifying what helps cancer patients start exercise before surgery
This qualitative systematic review of 20 studies identifies key facilitators and barriers to prehabilitation for cancer patients. The synthe…
Patients often want to get stronger before cancer surgery but face mental and social hurdles that can stop them from starting their fitness …
Tumor necrosis-related fever may occur during neoadjuvant chemoimmunotherapy for metaplastic breast carcinoma
Case Report Shows Tumor Necrosis Fever in Breast Cancer Treatment
This case report describes a patient with triple-negative breast cancer receiving neoadjuvant chemoimmunotherapy who experienced a tumor nec…
A single case study highlights how a persistent fever during chemotherapy may be caused by tumor necrosis rather than an infection.
5-year colonoscopy interval shows noninferiority to 3-year interval for colorectal cancer incidence
Trial shows longer gaps between colonoscopies may be safe for some
This interim analysis of a randomized controlled trial involving 10,799 patients with high-risk adenomas found that a 5-year follow-up inter…
A large study suggests that some patients with high-risk polyps can safely wait five years instead of three for their next colonoscopy.
SMMI framework provides a conceptual model for risk stratification in high-risk oral potentially malignant disorders
New Framework Helps Identify Risk of Oral Cancer Development
This evidence-ranked conceptual review proposes the spatial-microbial-metabolic-immune (SMMI) framework to study malignant transformation ri…
A new conceptual framework looks at how microbes and the immune system might help doctors better identify high risk for oral cancer developm…
Blinatumomab Improves Four Year Event Free Survival in Pediatric High Risk B Cell ALL
Trial shows blinatumomab improves survival for children with high-risk leukemia
Blinatumomab significantly improves 4-year event-free survival in children with high-risk B-cell ALL compared to standard chemotherapy.
A new trial shows that blinatumomab helps more children with high-risk B-cell leukemia stay healthy compared to standard chemotherapy.
Virtual reality technology may alleviate perioperative anxiety and pain in breast cancer patients
Virtual Reality May Reduce Pain and Anxiety in Breast Cancer Surgery
This scoping review of 15 studies examines the application and effects of virtual reality (VR) technology during the perioperative period fo…
Virtual reality technology may help breast cancer patients manage pain and anxiety during surgery and improve their physical recovery afterw…
Laparoscopic right hemicolectomy for ascending colon cancer with situs inversus totalis
Surgery for colon cancer in patients with internal organ reversal
A case report describes laparoscopic right hemicolectomy with intracorporeal anastomosis in a patient with ascending colon cancer and situs …
A new case report shows how surgeons can successfully treat colon cancer in patients with a rare condition where internal organs are flipped…
Prehabilitation reduces early urinary incontinence and improves quality of life after radical prostatectomy
Prehabilitation May Reduce Early Urinary Incontinence After Prostate Surgery
This meta-analysis of randomized controlled trials involving 1542 patients found that prehabilitation significantly reduces urinary incontin…
Prehabilitation may help reduce the risk of urinary incontinence in the months following radical prostatectomy for prostate cancer.