STRONG AYA infrastructure integrates clinical data and patient-reported outcomes for adolescent and young adult oncology
New European system helps doctors track young cancer patients' reported symptoms
A methodological report describes the implementation of the STRONG AYA pan-European infrastructure using federated learning and data visuali…
A new European system lets doctors track how young cancer patients report their symptoms and quality of life over time without moving privat…
Rezivertinib improves CNS progression-free survival versus gefitinib in EGFR-mutated NSCLC with baseline CNS metastases
Rezivertinib shows longer brain metastasis control than gefitinib in lung cancer trial
A phase III randomized controlled trial in 159 treatment-naïve patients with EGFR-mutated NSCLC and baseline CNS metastases found rezivertin…
Rezivertinib kept brain cancer growth in lung cancer patients under control for nearly two years longer than gefitinib in a major trial.
Focused ultrasound shows HPV clearance, LSIL resolution in meta-analysis of observational studies
Focused ultrasound shows promise for treating cervical cell changes and HPV
A meta-analysis of observational studies in women with cervical LSIL and concurrent hrHPV infection found focused ultrasound treatment was a…
Focused ultrasound cleared HPV in 74% of women and returned cervical cell changes to normal in 94%, outperforming observation and interferon…
vNOTES shows non-inferiority to laparoscopy for ovarian cystectomy in pilot trial
Can a gentler surgery remove ovarian cysts with less pain?
A pilot RCT of 64 patients with benign ovarian tumors compared vNOTES to conventional laparoscopy.
A gentler surgery that removes ovarian cysts through the vagina instead of the belly caused less pain after the operation, a small trial fou…
Computational framework reconstructs multidimensional clinical profiles from published Kaplan-Meier images
Can a computer reconstruct hidden patient stories from old cancer trial charts?
Methodological research using simulated data and empirical cancer cohorts (n=228 lung, n=929 colon) evaluated the MD-JoPiGo framework.
A new tool reconstructs hidden patient stories from old cancer trial charts, revealing how age and tumor markers interacted using only stand…
Systematic review finds highest glyphosate exposure associated with increased NHL risk
Higher glyphosate herbicide exposure linked to increased lymphoma risk in research review
A systematic review and meta-analysis of 20 observational study populations found that ever exposure to glyphosate-based herbicides was not …
People with the highest glyphosate herbicide exposure had about a 38% higher chance of developing non-Hodgkin's lymphoma compared to those w…
Network meta-analysis compares image-enhanced endoscopy techniques for colorectal lesions
Which colonoscopy technique works best for spotting suspicious growths?
A network meta-analysis of randomized controlled trials compared various image-enhanced endoscopy techniques for colorectal lesion detection…
Doctors have many high-tech tools to look for growths during a colonoscopy, but it's unclear which one is best.
Deep learning model using preoperative CT predicts lymph node metastasis in papillary thyroid carcinoma
Can a new AI model help thyroid cancer patients avoid unnecessary surgery?
A retrospective cohort study of 1560 PTC patients developed and validated ThyLNT, a Transformer-based 2.5D deep learning model using preoper…
A new AI model predicts lymph node spread in thyroid cancer better than standard scans, potentially sparing patients from unnecessary surger…
Nomogram predicts moderate-to-severe complications after primary tumor resection in metastatic colorectal cancer
Study identifies four factors linked to surgical complications in metastatic colorectal cancer
A retrospective single-institution cohort study of 404 metastatic colorectal cancer patients undergoing primary tumor resection identified a…
Older age, low albumin, tumor location, and long surgery time raise complication risks for metastatic colorectal cancer patients.
Sentinel Node Biopsy Associated with Reduced Melanoma Mortality and Recurrence in Meta-Analysis
Does checking lymph nodes help people with melanoma live longer?
A systematic review and meta-analysis of 13 studies with 40,287 adults with melanoma found sentinel node biopsy (SNB) was associated with a …
Checking lymph nodes during melanoma diagnosis is linked to a lower risk of dying from the cancer and less chance of it returning.
Ifinatamab deruxtecan shows antitumor activity in advanced treatment-refractory solid tumors in phase 1/2 trial
Early trial shows experimental drug shrinks tumors in some patients with advanced cancers
This first-in-human phase 1/2 trial of 97 patients with advanced treatment-refractory solid tumors found a confirmed objective response rate…
An early trial of a new experimental drug shrank tumors in 34% of patients with advanced cancers that had stopped responding to standard tre…
Lu-PSMA-617 plus pembrolizumab shows PSA response in mCRPC phase 1b/2 trial
Can a new drug combo help men with advanced prostate cancer?
In a single-arm phase 1b/2 trial of 37 patients with mCRPC, Lu-PSMA-617 plus pembrolizumab achieved a 50% PSA decline in 28 participants (76…
A new drug combo helped 28 of 37 men with advanced prostate cancer cut their PSA levels in half while keeping side effects mostly mild to mo…