Elevated CSF and blood sCD27 associated with autoimmune disease in severe psychiatric disorders and MS.
Could a simple protein in spinal fluid reveal hidden autoimmune disease in psychiatric patients?
This cohort study measured soluble CD27 (sCD27) in cerebrospinal fluid and blood from patients with severe psychiatric disorders, multiple s…
A simple spinal fluid protein may reveal hidden autoimmune disease in psychiatric patients who show signs of neuroinflammation.
Perx Health app linked to high medication adherence in older adults using real-world data
Seniors Are Sticking to Their Meds Thanks to a Surprising App Feature
This observational cohort study of 250 adults aged ≥65 years using the Perx Health mobile app in Australia and the United States found a med…
Gamified app features like leaderboards helped seniors aged 65 and older maintain a 95% medication adherence rate in real-world data.
Maternal diagnoses associated with autism in cousins, Danish registry study finds
Study links maternal health conditions to autism risk in cousins
This observational cohort study used Danish national registers to link maternal diagnoses with autism in cousins of index children. Several …
A new Danish study links maternal health conditions like epilepsy and depression to autism risk in cousins, suggesting shared genetic and en…
Italian guideline proposes organisational best practice framework
Can a new framework help Italian health services improve how they work?
This Italian guideline outlines the Organisational Clinical Best Practice Recommendations (O-BPCA) framework. The authors describe it as fea…
A new Italian health framework aims to close care gaps by standardizing how hospitals improve organizational performance and safety.
Delphi Consensus on Forensic Mental Health Systems and Services
For the First Time, Experts Agree on What Forensic Mental Health Care Should Look Like
This international Delphi guideline establishes a consensus-based framework for forensic mental health systems. It provides a definition, 12…
For the first time, 23 global experts agree on a shared blueprint for caring for people with mental illness involved in the justice system.
Case-control study links impaired decision-making tasks to suicide attempts in depressed patients.
Can't weigh risks and rewards? Suicide attempters show different decision-making patterns
This case-control study assessed 132 depressed patients with suicide attempts, patient controls, and healthy controls using clinical decisio…
People who attempted suicide weigh risks differently, showing less fear of loss and more impulsive errors that link directly to higher suici…
Narrative review of TRD epidemiology and CYP2C19 genotypes in Pakistan
New Clue Reveals Why Depression Meds Fail Some People
This narrative review summarizes a genetic epidemiological study in Pakistan involving 3677 adults with major depressive disorder. It report…
A major study shows that genes and family support are key to treating depression.
Comparative evaluation of simulated reasoning and self-verification for LLM psychiatric diagnosis
Study evaluates AI models for psychiatric diagnosis using case vignettes
This comparative evaluation assessed simulated reasoning and self-verification prompts for large language models using 106 psychiatric case …
AI models that check their own reasoning improved accuracy in diagnosing psychiatric disorders from case vignettes, though sensitivity gains…
Longitudinal MRI study links brain morphometry to treatment in schizophrenia spectrum disorders
Long-Term Schizophrenia Treatment May Reshape Brain Structure, Study Shows
This observational cohort study analyzed longitudinal structural MRI data from 350 individuals with schizophrenia spectrum disorders and 193…
Time spent on schizophrenia medication physically reshapes brain structure, linking treatment duration to lasting changes in the mind's orga…
Meta-analysis reviews parent-mediated intervention for infants at elevated autism risk
Teaching Parents a Skill That Could Change Their Baby's Developmental Path
This meta-analysis synthesizes evidence from eleven studies regarding parent-mediated early intervention for infants and toddlers at elevate…
Giving parents specific tools to engage with their infants before an autism diagnosis may help shape how the brain develops during the most …
Chinese female patients with anorexia nervosa showed no significant gut microbiota differences versus healthy controls.
The Gut-Brain Link in Anorexia Is Real — But More Complicated Than Expected
This cohort study compared gut microbiota profiles in 30 female patients with anorexia nervosa (AN) and 30 sex- and age-matched healthy cont…
Women with anorexia nervosa have different gut bacteria than healthy people, but these microbes don't predict illness severity or childhood …
Preoperative anxiety/depression linked to poorer outcomes in equinocavovarus foot surgery
Your Mindset Before Surgery Can Change How Well You Heal
A cohort study of 103 adult patients with equinocavovarus foot deformity at Xi'an Honghui Hospital found those with preoperative anxiety/dep…
Nearly half of foot surgery patients had anxiety or depression before the operation, and those patients ended up with more pain and less phy…