Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=49 Evaluate Inflammation Caused by Gingivitis in Adults
Gingivitis
Primary: Level of Gingival Crevicular Fluid Interleukin - 1 (GCF IL-1) at 2 Hours — 492.2; 326.3 Micrograms — p=0.05
N/A N=32 Induced Gingivitis & Intra-oral Imaging
Plaque Induced Gingivitis
Primary: Change From Baseline Gingivitis at Day 14 as Measured by Non-invasive Microimaging and Gingival Index. — 0.6; 0.15 units on a scale
N/A N=69 IFI16 is a Periodontitis Modulating Protein
Severe Periodontitis · Acute Inflammatory Response
Primary: Change in Absent in Melanoma 2 (AIM2) mRNA Expression Levels — 0.37; 0.65 fold change — p=0.3
Phase 3 N=39 Collection of Gingival Crevicular Fluid From Periodontitis Patients
Gingival Diseases
Primary: Metabolite Associated With Inflammation (Cadaverine) — 1.119186; 0.92077 ion count — p=<0.05
N/A N=158 A Clinical Trial to Test the Effect of Marketed Mouth Rinses on Decreasing Plaque and Gum Inflammation
Plaque · Gingivitis
Primary: Whole Mouth Mean Modified Gingival Index (MGI) at Week 3 — 2.004; 1.770; 1.807 units on a scale — p=<0.001
Phase 3 N=19 Investigation of Dental Plaque and Gingival Index
Dental Plaque
Primary: Gingival Margin Plaque Index — 15.4; 12.81 Units on a scale — p=0.05
N/A N=48 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3
Gingival Bleeding · Von Willebrand Diseases
Primary: Bleeding on Probing (BOP) — 14.5; 12.3 percentage of sites
Early Phase 1 N=35 Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model
Gingivitis
Primary: Proportion of Sites That Bleed on Probing
N/A N=32 Study of the Anti-Inflammatory Effects of Colgate Total® During an Experimental Gingivitis Model
Gingivitis
Primary: Change From Baseline in Plaque Index (Silness & Loe 1964) to Day 35 — 0.37; 0.44; 1.24; 1.49 units on a scale
N/A N=34 Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels
Chronic Peridontitis Patients · Chronic Gingivitis · Healthy
Primary: Pocket Depth — 1.60; 2.50; 6.75 millimetres
Phase 2 N=127 Safety and Preliminary Efficacy of Lipoxin Analog BLXA4-ME Oral Rinse for the Treatment of Gingivitis
Gingival Inflammation
Primary: Incidence of Adverse Events — 19; 10; 3 Participants
Phase 2 N=71 Safety and Tolerability of Antiplaque Chewing Gum in a Gingivitis Population
Plaque · Gingivitis
Primary: Safety and Tolerability of KSL-W as Measured by Soft Tissue Erythema, Ulceration and Sloughing (AEs and SAEs) — 2; 1; 4; 2 Participants
N/A N=30 The Effectiveness of Brushing and Flossing Sequence on Control of Plaque and Gingival Inflammation
Gingival Inflammation · Plaque · Gingival Bleeding
Primary: Change From Baseline in Mean BPI Index Scores at 2 Weeks — 0.396; -1.028 score on a scale — p=0.022
Phase 3 N=73 Clinical Research Study Efficacy of a Prototype Oral Rinse
Dental Plaque
Primary: Gingival Index — 1.90; 1.84 Units on a scale — p=0.005
N/A N=61 Trial of Toothpaste to Reduce Plaque and Inflammation
Plaque · Inflammation
Primary: Change in Oral Plaque — -1.05; -0.03 log(percentage) — p=0.001
Phase 4 N=69 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis
Gingivitis · Plaque, Dental · Periodontal Diseases
Primary: Degree of Plaque as Assessed by the Turesky Modification of the Quigley-Hein Plaque Index — 0.41; 0.43 score on a scale
Phase 2 N=46 Use of Topical Subgingival Application of Simvastatin Gel in the Treatment of Peri-Implant Mucositis
Peri-implant Mucositis
Primary: Change in Interleukin 1 B at Base to 24 Hours — -1.075; 1.013 Micrograms per deciliter (ug/dl) — p=0.90
N/A N=200 A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis
Plaque
Primary: Plaque Index Score Per Participant at 6 Months — 2.12; 2.70; 2.23; 2.84 score on a scale — p=<0.0001
Phase 3 N=38 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis
Aggressive Periodontitis
Primary: Change in Probing Depth — 3.88; 3.74; 3.38; 3.26 milimeters — p=<0.05
N/A N=51 Kidney and Periodontal Disease Study
Chronic Kidney Disease · Periodontal Disease
Primary: Number of Participants Completing Study Protocol — 17; 34; 14; 30 Participants
Phase 3 N=15 Train New Examiners Via Modified Gingival Margin Plaque
Dental Plaque
Primary: Mean Gingival Plaque Units — 13.38; 14.29 Units on a scale — p=0.05
N/A N=253 Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease
Gingivitis
Primary: Number of Bleeding Sites at Week 12 — 42.02; 67.36 number of bleeding sites — p=<0.0001
Phase 2 N=60 Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP
Gingivitis · Periodontitis
Primary: Changes in Modified Gingival Index (MGI) — 8.5; 1.5 score on a scale — p=<0.001
Phase 3 N=96 Safety and Efficacy of Gintuit(TM)for Oral Soft Tissue Regeneration
Gingival Recession
Primary: Percentage of Subjects With at Least 2 mm Keratinized Tissue (KT) at 6 Months at the Gintuit Treated Site. — 95.3 percentage of participants — p=<0.0001
Phase 2 N=120 Assessing Gingivitis of 3 Different Dentifrices Compared to a Negative Control.
Gingivitis
Primary: Number Bleeding Sites — 31.52; 25.90; 21.65; 19.13 number of bleeding sites
Phase 2 N=110 A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis
Gingivitis
Primary: Number of Bleeding Sites at 6 Weeks (Comparison of Experimental Versus Negative Control Dentifrice) — 9.5; 20.5 Number of Sites — p=<0.0001
N/A N=80 Iranian Traditional Mouth Rinse Punica Granatum Pleniflora (Golnaar) in Treatment of Gingivitis in Diabetic Patients
Gingivitis
Primary: Plaque Index — 2.3; 2.5; 1.9; 2 units on a scale
N/A N=34 Investigation of the Safety and Efficacy of Pocket-X Gel
Periodontal Pocket
Primary: Change in Periodontal Pockets Probing Depth — 6.97; 6.81; 7.67; 7.72 mm
N/A N=15 Gingival Crevicular Fluid Characterization During Orthodontic Treatment
Healthy · Maxillary First Premolar Tooth Extraction · Canine Retraction
Primary: The Distance of Tooth Movement — 5 millimeters