Early Phase 1 N=131 Managing Chronic Pain in Veterans With Substance Use Disorders
Chronic Pain
Primary: Pain Intensity, as Measured by Average Pain Within the Last Week (NRS-1) — 5.82; 6.47 units on a scale — p=<0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Early Phase 1 N=16 Study of the Effect of Sitagliptin on Glucose (Sugar) Metabolism in Patients With Heart Failure
Heart Failure, Congestive
Primary: Determine the Effects of Sitagliptin on Myocardial Glucose Uptake Measured by Myocardial PET Scan — 3.4; 4.1 SUV
Early Phase 1 N=87 Nicotine Patch Pretreatment for Smoking Cessation in PTSD
Stress Disorders, Posttraumatic · Tobacco Use Disorder
Primary: Smoking Abstinence, Self-reported — 5; 11 participants
Early Phase 1 N=40 Anal Resting Pressure After Bidet, Compared to Sitz Bath
Anorectal Disorders
Primary: Anal Resting Pressure Change — 90.2; 71.3; 88.1; 69.6 mmHg
Early Phase 1 N=80 Human Tissue Distribution of Orally Supplemented Natural Vitamin E Tocotrienol
End Stage Cardiac Failure · Pulmonary Failure · End Stage Liver Disease
Primary: The Levels of TCT in the Tissues of "Non-healthy" Subjects and in the Tissue of "Healthy" Subjects Following Oral Supplementation (200 mg x 2 Per Day for 4-24 Weeks)…
Early Phase 1 N=5 The Effects of Tiotropium on the Cough Reflex in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease · Chronic Bronchitis
Primary: Number of Coughs Following Capsaicin Inhalation Challenge at Baseline and Following 30 Days of Treatment With Spiriva (Baseline and 30 Days) — 2.5 coughs per dose of…
Early Phase 1 N=64 Neurocognitive and Neurobiological Improvement in ADHD Children by Modification of Dietary Protein
ADD · ADHD
Primary: Reaction Time at 3 Months — 506.58; 510.59 milliseconds — p=0.56593
Early Phase 1 N=20 Metabolic Causes of Thrombosis in Type 2 Diabetes - Question 4
Type 2 Diabetes
Primary: Percent Changes in Endothelial Function as Measured by Flow Mediated Dilation by 2D Doppler Ultrasound on Day 2 — 2; 7 percentage of change
Early Phase 1 N=4 Evaluation of the Use of AZD6244 to Induce Increased ER Expression and Anti-Estrogen Response in ER-Negative/Low Breast Cancer
Breast Cancer
Primary: Increase of ER Protein Expression in ER-Negative/Low Breast Cancer — 1 participants
Early Phase 1 N=55 Pilot Study on Mindfulness for Tobacco and Alcohol in University Students
Nicotine Dependence · Alcohol Use
Primary: Smoking Abstinence — 6; 1 participants
Early Phase 1 N=8 The Role of Gadoxetate (Eovist) Enhanced CT in Evaluating Cholangiocarcinoma
Cholangiocarcinoma
Primary: Number of Subjects Where Hilar Cholangiocarcinomas Could be Visualized Using Gadoxetate Disodium Enhanced Dual Energy CT — 5 participants
Early Phase 1 N=70 Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
Postoperative Pain · Adverse Effects
Primary: Patients With Pain: Numerical Rating Scale (NRS-11(0-10): 0:no Pain and 10:Severe/Worst Pain) ≥ 4 — 19; 5; 11 participants
Early Phase 1 N=22 Quantifying Airway Inflammation With Radiologic Tests
Lung Inflammation
Primary: Change in Ki (Measure of [18F]Fluorodeoxyglucose ([18F]FDG) Uptake Determined by Patlak Graphical Analysis) in the Right Lung 24 Hours After LPS Instillation — 18.8…
Early Phase 1 N=21 Study of a Topical Nasal Spray to Ease the Symptoms of Hayfever
Rhinitis, Allergic, Seasonal
Primary: Change From Baseline in the Total Nasal Symptom Score (TNSS) at 15 Minutes After the First Allergan Challenge — 2.90; 3.69 units on a scale — p=0.156
Early Phase 1 N=48 Users Study Of The Caverject Delivery System
Healthy
Primary: Delivery System Success Rate (DSSR) — 66.67; 66.67; 100.00; 100.00 percentage of participants