N/A N=56 Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea
Sleep Apnea, Obstructive
Primary: Experimental Cold-induced Pain - IGFBP-1 — 0.0025 [sec/(mcg/mL)] /pg/mL — p=<0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=26 Hyperalgesia in Methadone-Maintained Patients: Can it be Treated?
Opioid-Induced Hyperalgesia
Primary: Change in Pain Threshold Time From Baseline to Week 5 — 2.95; -3.49 seconds
Phase 3 N=105 Analgesic Effect of Peripheral Dexmedetomidine
Third Molar Extraction
Primary: Pain Score at Rest — 165.5; 218.2; 233.8 score on a scale×hr
N/A N=100 Mechanisms of Sleep Disruption Hyperalgesia
Sleep Deprivation · Pain
Primary: Spinal Sensitization as Assessed by Area of Secondary Hyperalgesia (2HA) After Two Nights of Uninterrupted Sleep and Two Nights of 8 Forced Awakenings — 1276.25…
Phase 1 N=30 Neural Correlates of Lidocaine Analgesia
Anesthesia · Pain
Primary: Brain Activation to Painful Stimulation Difference: Drug-free Condition Minus Lidocaine Condition — 3.6 Z-score — p=0.004
Phase 3 N=17 Neuroimaging Study of Dexmedetomidine-Induced Analgesia
Analgesia · Anesthesia
Primary: CSF Flow Measured in Hz — -15 Hz
Phase 4 N=62 Analgesia Regimens Following Trans-sphenoidal Surgery for Pituitary Tumors
Pituitary Tumor · Pain
Primary: Comparison of Mean Pain Scores Between Two Arms (Measured Every 4 Hours Over 48 Hour) — 1.7; 2.8 0-10 units on a scale
N/A N=22 Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil
Hyperalgesia
Primary: Pain Tolerance — 105.3; 19.2 seconds
N/A N=7 Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Analgesia
Postoperative Pain
Primary: Change From Baseline of Surgical Site Pain Level (NRS) at Rest [Percentage of Baseline Pain] — 64; 100; 55; 69 percentage of baseline
N/A N=20 Feasibility of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery
Rotator Cuff Injuries · Shoulder Disease · Hallux Valgus
Primary: Average Daily Pain Intensity 1st Week — 2 units on a scale
N/A N=122 Percutaneous Auricular Neuromodulation for Postoperative Analgesia
Postoperative Pain, Acute
Primary: AVERAGE Pain Measured With the Numeric Rating Scale First 5 Postoperative Days — 1; 3 units on a scale
Early Phase 1 N=22 Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Chronic Pain · Opiate Dependence · Lower Back Pain
Primary: Change in Quantitative Pain Testing Following Active TMS Compared to Baseline — 1.4; .3 Change from Baseline (degrees C) — p=.83
N/A N=100 Vibration Analgesia in Propofol Infusion During Anesthesia Induction
Pain, Acute
Primary: Level of Pain as Observed by Two Independent Observers Following Propofol Injection, With or Without a Vibration Analgesia Adjunct — 3.1; 1.4 units on a scale
Phase 4 N=80 Analgesia After Total Shoulder Arthroplasty
Total Shoulder Arthroplasty
Primary: Numeric Rating Scale (NRS) Pain Score With Movement — 4.5; 3.4; 4.2; 4.9 units on a scale
Phase 1 N=32 Memory Modulation by Pain During Anesthesia
Amnesia · Pain · Anesthesia
Primary: Memory Testing — 1.20; .56; .82; 1.18 d' score
N/A N=93 Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function
Chronic Pain
Primary: Mean of the Change in Morphine Dosage (in mg) Required to Achieve 25% Reduction in Thermal Evoked Pain Responses Relative to Baseline (Pre-intervention) Placebo…
N/A N=161 Symptom Management Efficacy Study to Reduce Distal Neuropathic Pain
Neuropathic Pain · HIV Neuropathy · HIV/AIDS
Primary: Gracely Pain Scale (GPS) — -2.51; -1.96; -2.38; -0.99 GPS pain score on a scale
N/A N=78 Effect of Nitrous Oxide in Treating Neuropathic Pain: A Study in Chronic Low Back Pain Patients
Low Back Pain · Radiating Pain
Primary: Change in VAS Pain Score From Baseline to 3 Month Follow-up — -1.6; -1.2 units on a scale — p=0.84
N/A N=280 Individualized Analgesia After Adenotonsillectomy
Analgesia
Primary: The Percentage of Patients Requiring at Least One Medical Intervention for Respiratory Events — 16; 29 Participants — p=<0.05
N/A N=94 Opioid Sparing Potential of Light-Induced Analgesia
Pain
Primary: Change in Pain Level — 1.15; -0.04; 1.07 score on a scale
N/A N=34 Lidocaine for Diabetic Peripheral Neuropathy
Diabetes · Peripheral Neuropathy · Pain
Primary: Change in Spontaneous Pain at 60-120 Minutes After Lidocaine Infusion Initiated (Assessed on 0-10 NRS) — 33; 51 percentage of pain change from baseline — p=0.03
N/A N=144 Cryoanalgesia to Treat Post-Amputation Phantom Limb Pain: A Department of Defense Funded Multicenter Study
Post-Amputation Phantom Limb Pain
Primary: Change From Baseline in Average Daily Phantom Pain Intensity — 0.5; 0 score on a scale
N/A N=99 Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlled Study
Mastectomy · Upper Limb Amputation Below Elbow · Upper Limb Amputation Above Elbow
Primary: Average Pain (Mastectomy Subjects Only) — 0.0; 3.0 score on a scale
N/A N=122 Protective Analgesia for Postoperative Pain Relief Following Day Case Oral Surgery
Postoperative Pain · Wisdom Tooth
Primary: Number of Patients Needing Rescue Medication — 32; 29 Participants
Phase 4 N=100 A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery
Opioid Use
Primary: Amount of Pain Experienced — 28; 35 Score on a scale
Phase 4 N=100 Multimodal Versus Opioid aNalgesia in carDiAc Surgery
Postoperative Pain · Postoperative Delirium
Primary: Postoperative Pain After Cardiac Surgery — 2.28; 2.17 units on a scale
Phase 2 N=26 Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial
Central Neuropathic Pain · Allodynia · Spinal Cord Injury
Primary: Percent Change in Peak Pain Intensity — -2.5; -7.9; -11.2; -19.2 percentage change from baseline — p=0.0322
Phase 2 N=39 Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment
Chronic Pain
Primary: Post-operative Morphine Consumption — 54.6; 44.8 mg — p=0.5
Phase 4 N=30 Peripheral Nerve Blocks for Above-the-knee Amputations
Peripheral Vascular Diseases · Hyperglycaemia (Diabetic) · Hypertension
Primary: Peripheral Nerve Block Success as a Primary Anesthetic — 1 Participants
N/A N=53 The Effect of Neurontin on Pain Management in the Acutely Burned Patient
Pain · Burn Injury
Primary: Opioid Consumption Between the Treatment and the Control Groups (Morphine Equivalents) — 7.0; 6.7 morphine equivalents — p=<0.05