Phase 4 N=45 Nebivolol, Lifestyle Modification and Arterial Stiffness
Hypertension
Primary: Beta-stiffness Index — -2.03; -1.87; -2.51 Arbitrary units
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=33 RAAS and Arterial Stiffness in SCI
Arterial Stiffness · Renin Angiotensin Aldosterone System · Orthostatic Hypotension
Primary: Pulse Wave Velocity (m/s) — 8.81; 7.36; 5.53 m/s
Phase 3 N=70 Safety Study to Lower the Risk of Heart Failure is Also Effective in Reducing Stiffness of the Arteries
Hypertension · Diabetes
Primary: Change in Central Systolic Blood Pressure (SBP) — 125.3; 127.8; 121.6; 123.8 mmHg
N/A N=60 Arterial Stiffness in Type I Diabetes Mellitus
Arterial Stiffness in Youth With Type 1 Diabetes
Primary: Determine the Difference Between Acute Effect of a Mixed Meal on Radial Artery Stiffness in Subjects With Type I Diabetes Mellitus Who do and Who do Not Take an…
N/A N=51 Impact of Grafts and Endografts for Abdominal Aneurysms on Arterial Stiffness.
Aortic Aneurysm, Abdominal
Primary: Aix@75 — 31.8; 32.5 percentage
Phase 2 N=43 Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease
Cardiovascular Disease · Chronic Kidney Disease
Primary: Aortic Pulse Wave Velocity (PWV) — 9.90; 9.96; 7.62; 8.57 m/s — p=0.685
Phase 3 N=137 ENAC Blockade and Arterial Stiffness
Overweight and Obesity · Insulin Resistance
Primary: Carotid Femoral Pulse Wave Velocity — 7.25; 6.80; 7.12; 6.81 m/s
Phase 2 N=34 Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid
Diabetes Mellitus, Type 2 · Hyperuricemia
Primary: Carotid Femoral Pulse Wave Velocity (cfPWV) — 8.71; 7.8; 8.28 m/s
N/A N=60 Strategies for Aggressive Central Afterload Reduction in Patients With Heart Failure
Heart Failure
Primary: Change in Peak Oxygen Uptake (VO2) During Maximal Effort Exercise Stress Test According to Ejection Fraction Subgroups — 1.5; -0.5; 2.0; -1.0 percentage of change in…
N/A N=58 Exercise and Arterial Stiffness in Systemic Lupus Erythematosus
Systemic Lupus Erythematosus
Primary: Arterial Stiffness — -0.26; -0.22 m/s
N/A N=92 Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
Arterial Stiffening · Aging · Menopause
Primary: Arterial Stiffness (Carotid Artery Compliance) During Saline — 1.31; 1.34; 0.90; 1.02 mm2/mm Hg×10-1
Phase 2 N=454 Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With Hypertension
Hypertension
Primary: Change From Baseline in Mean Central Aortic Systolic Pressure (CASP) at 12 Weeks — -12.57; -8.90 mmHg — p=0.010
Early Phase 1 N=16 Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
Aging · Arterial Stiffness · Endothelial Dysfunction
Primary: Change in Carotid Artery Compliance in mm/mmHg x 10-1 — 0.88; 0.87; 0.90; 0.79 mm/mmHg x 10-1
N/A N=60 Effects of Agonists of Glucagon Like Peptide - 1 Receptors (GLP-1R) on Arterial Stiffness, Endothelial Glycocalyx and Coronary Flow Reserve in Patients With Coronary Artery Disease and Patients With Diabetes Mellitus
Type 2 Diabetes Mellitus · Coronary Artery Disease
Primary: Differences in Pulse Wave Velocity at Baseline and 3, 6 and 12 Months After Treatment With Metformin or Agonist GLP-1R. — 11.8; 11.2; 11.6; 11.5 m/s
N/A N=100 The Effects of Swimming on Elderly Women With Stage-2 Hypertension
Menopause · Hypertension
Primary: Arterial Stiffness — 7.8; 10.0 m/s
Phase 3 N=559 A 24-week Arterial Stiffness Study With Fluticasone Furoate/Vilanterol in COPD
Pulmonary Disease, Chronic Obstructive
Primary: Mean Change From Baseline (BL) in Aortic Pulse Wave Velocity (aPWV) at the End of the 24-week Treatment Period (Day 168) — -1.97; -1.95; -1.75 meters per second (m/sec)…
N/A N=1,342 International Registry for Ambulatory Blood Pressure and Arterial Stiffness Telemonitoring
Hypertension
Primary: 24-hour Pulse Wave Velocity (PWV) — 10.6 m/s
Phase 2 N=45 Targeting Inflammation to Treat Cardiovascular Aging
Vascular Stiffness · Endothelial Dysfunction · Diastolic Dysfunction
Primary: Carotid-femoral Pulse Wave Velocity (CFPWV) — 831.3; 785.1; 538.0; 839.6 cm/sec
Phase 4 N=465 Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection Fraction
Heart Failure and Reduced Ejection Fraction
Primary: Change From Baseline in Aortic Characteristic Impedance at Week 12 — -0.7; -2.9 dyne x sec/cm5 — p=0.7827
Phase 3 N=30 Comparison of Aliskiren vs Negative Controls on Aortic Stiffness in Patients With MFS
Marfan Syndrome
Primary: Central Aortic Distensibility by MRI — 3.7; 4.7; 5.7; 5.1 (mmHg ^ -1) x 10 ^ -3
N/A N=16 Early Diagnosis of Diastolic Dysfunction and Reliability of DSE in Detecting Stress Diastolic Dysfunction
Diastolic Dysfunction
Primary: Change in Left Ventricle Mean Diastolic Pressure — 3.3 mmHg
Phase 3 N=40 Effects of Losartan Versus Atenolol on Aortic and Cardiac Muscle Stiffness in Adults With Marfan Syndrome
Marfan Syndrome
Primary: Aortic Biophysical Properties - Pulse Wave Velocity — -1.15; -0.22 change in meters/second
Phase 2 N=114 A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With Hypertension
Hypertension
Primary: Change From Baseline in Ascending Aorta Distensibility at 52 Week — 0.269; 0.330 10^(-3) x mmHg^(-1) — p=0.7324
Phase 4 N=72 A Study of Postprandial Hyperglycemia in Participants With Type 2 Diabetes
Diabetes Mellitus, Type 2
Primary: Postprandial Pulse Wave Velocity (PWV) in Type 2 Diabetes Mellitus (T2DM) Participants at 30 Minutes (Mins) Pre-Breakfast — 10.99; 10.73; 11.56; 11.31 meters per second…
Phase 4 N=201 LAAS (Losartan Anti-Atherosclerosis Study)(0954-330)(COMPLETED)
Hypertension
Primary: Pulse Wave Velocity (PWV) Changes From Baseline (Visit 2) to 24 Weeks (Visit 6) After the Administration of the Study Drug — 0.28; -0.12 meters/second
Phase 2 N=60 Vitamin K2 Supplementation and Arterial Stiffness in the Renal Transplant Population (The KING Trial)
Arterial Stiffness · Vitamin K2 Deficiency
Primary: Reduction From Baseline in Carotid-femoral Pulse Wave Velocity at 8 Weeks — -1.4 m/s
N/A N=14 Vascular Dysfunction During Physical Inactivity
Aging · Vascular Endothelium · Skeletal Muscle
Primary: Brachial Artery Vascular Function — 5.1; 3.1; 4.4 percent vasodilation
N/A N=16 Effect of Oral Caffeine and L-Citrulline Supplementation on Arterial Function in Healthy Males
Hypertension · Healthy
Primary: Aortic Blood Pressure — 5; 6; 4; 4 mmHg — p=<0.001
N/A N=55 Determination of Liver Stiffness in Chronic Liver Disease Patients by Acoustic Radiation Force Imaging (ARFI) Ultrasound
Chronic Liver Disease
Primary: Agreement in Measured Liver Stiffness Between ARFI and MRE — 3.21; 2.48; 1.81; 2.0 kPa
N/A N=45 Scleroderma ARFI Imaging of the Skin
Scleroderma
Primary: Mean Skin Stiffness — 2.68; 2.07; 2.23; 2.27 meters per second — p=0.005