N/A N=12 Health & Aging Brain Study: Health Disparities TAU Project
Brain Aging in Mexican Americans
Primary: Tau Accumulation Measured by PET Imaging — 12 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=30 Happy Older Latinos Are Active - Cognitive Decline
Cognitive Decline
Primary: Percentage of Participants Completing the Study — 90 Percentage of participants
N/A N=122 Exercise Effects on Brain Health and Learning From Minutes to Months
Sedentary Lifestyle
Primary: Change in Hippocampal-dependent Learning — -.00369; .00404 learning rate (proportion correct/trial) — p=<.05
Phase 3 N=221 Preventing Cognitive Decline in African Americans With Mild Cognitive Impairment
Mild Cognitive Impairment (MCI)
Primary: Number of Participants With a Decline of 6 Points on the Hopkins Verbal Learning Test-Revised (HVLT-R) — 1; 9 Participants — p=.02
Phase 4 N=95 Brain Aging and Treatment Response in Geriatric Depression
Mild Cognitive Impairment (MCI) · Depression
Primary: Change in Hamilton Depression Rating Scale — 17.8; 17.7; 6.0; 6.7 units on a scale
N/A N=39 A Physical Activity Program to Disrupt Sedentary Time in Older Latinos
Sedentary Behavior · Cognitive Impairment
Primary: Number of Sedentary Bouts — -11.58; -2.47 Sedentary bouts
N/A N=39 A Multidomain Approach to Preventing Dementia in African Americans: Cognitive Prescriptions
Cognitive Change · Health Behavior · Health Literacy
Primary: Leisure Activities Questionnaire Activities Sum — 1.45; 4.45; 11.25 score on a scale — p=<0.05
N/A N=101 Improving Medication Adherence in Older African Americans With Diabetes
Type 2 Diabetes · Mild Cognitive Impairment
Primary: Percent of Participants With Improvement in Hemoglobin A1c by 0.5%" — 25; 22 Participants — p=0.31
Phase 1 N=243 Feasibility of a Systems Approach for Alzheimer's Services Among Latinos Attending Primary Care Practices
Dementia
Primary: Provider Recruitment Feasibility — 1.44 Providers trained per month
N/A N=22 iBAILA - Investigating Brains & Activity to Improve Latino Aging
Sedentary Behavior · Cognitive Impairment
Primary: Community Healthy Activities Model Program for Seniors (CHAMPS) Physical Activity Questionnaire for Older Adults — 402.0; 315.0; 492.0; 326.3 Minutes per week
N/A N=107 Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment
Mild Cognitive Impairment · Alzheimer's Disease
Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized
N/A N=290 Multicultural Healthy Diet to Reduce Cognitive Decline
Diet Modification · Cognitive Decline · Cognitive Change
Primary: Change in Mean Global Composite Cognition Score From Baseline — 0.2; 0.2 Z-score — p=0.259
N/A N=13 Efficacy of a Multimodal Brain Health Intervention for Older African Americans
Cognitive Impairment, Mild · Cognitive Decline
Primary: Daily Average Steps Recorded by Actigraphy Watch — 2570; 1140 daily step count
Phase 2 N=125 Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study
Alzheimer Disease · Cognitive Decline
Primary: Standardized Uptake Value Ratios (SUVrs) Calculated From [18F]AV-1451 PET Scans — 1.09 standardized uptake value ratio
Phase 1 N=145 Alzheimer's PET Imaging in Racially/Ethnically Diverse Adults
Alzheimer Disease
Primary: Regional SUVR Value for 18F-MK-6240 — 1.27 SUVR
N/A N=21 Patient Priorities Care for Hispanics With Dementia
Multiple Chronic Conditions · Dementia
Primary: Self-reported Perceived Value of Patient Priorities Care (PPC) Approach — 75; 85.7 percentage of participants
Phase 2 N=31 Memory and Insulin in Early Alzheimer's Disease
Alzheimer's Disease
Primary: fMRI Measure of Hippocampal Activation — 36.4; 41.3 percentage of active voxels
Phase 1 N=24 CuidaTXT: a Text Message Dementia-caregiver Intervention for Latinos
Caregiver Burnout
Primary: Percentage of Participants Able to Opt Into CuidaTXT (Enrollment Feasibility) — 24 Participants
N/A N=10 Engage Coaching for Latinos
Social Isolation · Loneliness · Caregiver Burnout
Primary: Change From Baseline in Loneliness at Post Intervention — 51.125000; 53.000000 score on a scale
Phase 2 N=98 Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease
Mild Cognitive Impairment · MCI · Aging
Primary: fMRI Measurement — 2267.0; 1491.23; 673.31; 989.19 voxels
Phase 2 N=30 The Efficient Brain Study
Metabolism - Cerebral Energy
Primary: Magnetic Resonance Spectroscopy (MRS) Will Measure a Change in Cerebral Energy Function in Brain Tissue — .011; .007; .009; .006 Difference in metabolite amplitude
N/A N=966 Twitter Based Social Support for Hispanic and Black Dementia Caregivers
Loneliness · Emotional Stress
Primary: Number of Participants Who do Not Engage in Twitter Activities — 246; 226 Participants — p=< 0.0001
N/A N=119 Exercise for Brain Health in the Fight Against Alzheimer's Disease
Healthy Cognition
Primary: Rey Auditory Verbal Learning Test Sum of Trials 1-5 — 49.7; 47.6; 51.6; 49.4 Sum of words recalled Trials 1 to 5
N/A N=78 Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)
Alzheimer Disease · Dementia
Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items
N/A N=108 Better Memory With Literacy Acquisition Later in Life
Memory Impairment
Primary: Episodic Memory Improvement — 31.8; 31.3 score on a scale — p=0.531
Phase 2 N=80 Metformin in Amnestic Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Change in Total Recall Score in the Selective Reminding Test — 5.7; 9.4 score on a scale — p=0.05
Phase 2 N=26 Network-Level Mechanisms for Preclinical Alzheimer's Disease Development
APOE 4
Primary: Functional Connectivity Strengths of Neural Networks — 0.233; 0.318 Pearson coefficient — p=0.007567
N/A N=129 Ca:Mg Ratio and Cognitive Function
Cognitive Function
Primary: Overall Score Changes From Baseline by Magnesium Treatment vs. Placebo — 1.1; 0.6 score on a scale — p=0.20
N/A N=20 Cognition and Magnetic Resonance Imaging of Brain Inflammation in Obesity
Obesity
Primary: Brain Inflammation Metrics in Obese and Normal-weight Individuals as Measured by Magnetic Resonance Image-based Diffusion Basis Spectrum Imaging (DBSI) — .0468; .0492…
N/A N=20 "Healthy Actions and Lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia Program"
Dementia · Alzheimer's Disease · Dementia Prevention
Primary: Users' Engagement With the HALT-AD Online Platform by Measuring the Total Amount of Time (in Minutes) Spent Per User on All Courses Combined — 136 minutes