Clinical Trial Search

Primary: Average Change From Baseline in American Orthopedic Foot and Ankle Society(AOFAS) at 12 Months Post-surgery — 16.93 scores

Primary: Knee Cartilage Volume — 2042; 1971 mm³

Primary: Safety: Adverse Events — 0 participants

Primary: Degree of Filling of the Lesion by Repair Tissue at 12 Months Through MRI. — 92.81; 85.22 Percentage of lesion fill — p=0.011

Primary: MRI Repair Tissue Comparison — 10; 2; 3; 4 Participants — p=0.61

Primary: Cartilage Volume Loss of the Lateral Compartment — 6408; 6196; 6196; 6143 cubic milimeters

Primary: Knee Injury and Osteoarthritis Outcome Score (KOOS) (Clinical Outcome) — 12.0; 4.1; 19.1; 8.1 units on a scale — p=0.162

Primary: Number of Participants With Viable Specimens for Genetic Analysis — 14 participants

Primary: Change in Numerical Pain Scale — -3.2 units on a scale

Primary: Knee Flexion Moment Impulse — 0.54; 0.50 Ratio — p=0.293

Primary: Change From Baseline in the International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Score at 1 Year — 23.3; 9.9 scores on a scale — p=<0.01

Primary: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Score); Change From Baseline at 4 Months — 27.1; 33.3; 28.9; 26.7 units on a scale

Primary: Change From Baseline in Cartilage Volume in the Index Region Measured by 7 Tesla MRI — 63.3; 49.8; 11.6 µL — p=0.2366

Primary: Histomorphometry Safranin-O + Anti-Collagen II Antibody Staining — 1.01; 0.75 Ratio — p=0.003

Primary: Number of Participants Experiencing One or More Treatment-Emergent Adverse Event — 28; 33 Participants — p=>0.9

Primary: IKDC Score — 32.0; 25.5 score on a scale

Primary: Degree of Lesion Filling (%Fill) by Repair Tissue at Degree of Lesion Filling (%Fill) by Repair Tissue at 5 Years Through MRI. — 93.79; 86.96 Percentage of lesion filled…

Primary: Change in Synovial Interleukin (IL) -1 Receptor Antagonist Concentration — 13.8; 16; 9.9; 7.5 pg/ml

Primary: Change at 6 Months From Baseline in First Peak Knee Adduction Moment (KAM): (6 Month Value - Baseline) — -0.19 %Bw*Ht

Primary: Cross-sectional Area (CSA) of Muscle Fibers — 2680; 2377; 2028; 1882 micron squared

Primary: Joint Contact Stress Time Exposure (Model Estimated) — 4.44; 3.97; 4.08; 4.25 MPa-s/gait cycle

Primary: Change in Lean Mass Measured by DXA — -2.9; -2.3 Kg

Primary: Medial Condylar Separation With Brace — 0.60 mm

Primary: Change in International Knee Documentation Committee (IKDC) Subjective Knee Form Score — 22.2; 20.6 units on a scale

Primary: The Lysholm Knee Score — 82.2; 83.4 units on a scale

Primary: Visual Analogue Scale Pain Score — 2.3 units on a scale

Primary: Changes in Serum COMP Accumulation, Triggered by Acute Exercise, After 12 Weeks of Different Regular Exercises — -1.60; -0.53; -0.19; -0.12 U/l

Primary: To Identify Imaging Markers for Characterizing the Biochemical Profiles in Synovial Fluid and Cartilage in Knee OA After HA Injection

Primary: T1rho Relaxation Times in the Medial Femoral Condyle at Baseline — 53.48 ms

Primary: Change in the Total WOMAC Score (WOMAC-T) — 1137.13; 767.47; 1271.60; 445.33 score on a scale — p=0.00