Phase 4 N=14 Sleep and Breathing in the General Population - Chemical Stimuli
Sleep-disordered Breathing
Primary: The Central Apnea-hypopnea Index — 14.1; 29.9 events per hour
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=29 Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients
Cheyne-Stokes Respiration · Sleep Apnea, Central
Primary: Apnea/Hypopnea Index (AHI) — 55; 37; 12 Apnea-Hypopnea events per hour
N/A N=66 Complex Sleep Apnea Syndrome (CompSAS) Resolution Study
Complex Sleep Apnea Syndrome
Primary: Apnea-hypopnea Index (AHI) Per Polysomnography (PSG) at the End of Treatment Period — 4.4; 9.9 AHI (events/hour)
N/A N=169 Sleep Apnea Intervention for Cardiovascular Disease Reduction
Obstructive Sleep Apnea
Primary: Change From Baseline in 24-hour Blood Pressure at Months 6 and 12 by Pooled Arms — 1.82; 1.06; 0.59; -0.73 mmHg
N/A N=25 Servo-Ventilation In-lab PSG Evaluation
Sleep Apnea Syndromes
Primary: Average Apnea Hypopnea Index Among Different Polysomnography Devices. — 18.4; 25.4; 24.1; 19.2 events per hour
Phase 3 N=225 Diagnosis and Treatment of Sleep Apnea in Cerebrovascular Disease
Obstructive Sleep Apnea · Stroke · Transient Ischemic Attack
Primary: Sleep Apnea Diagnosis Rate — 58; 5 participants
N/A N=21 Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use
Obstructive Sleep Apnea · Central Sleep Apnea (Diagnosis) · Chronic Opioid Use
Primary: Apnea Hypopnea Index (AHI) — 2.5; 16.3 events/hour
N/A N=74 Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury
Obstructive Sleep Apnea · Hypercapnia · Spinal Cord Injury
Primary: Prevalence of Sleep-disordered Breathing in Spinal Cord-injured Adults — 40; 23; 11 participants
Phase 3 N=240 Effect of Self-Management on Improving Sleep Apnea Outcomes
Sleep Apnea Syndromes
Primary: CPAP Adherence — 2.8; 3.9 hours per night — p=0.001
Phase 4 N=74 Oxygen Versus PAP for Sleep Apnea in Heart Failure
Heart Failure · Sleep Apnea Syndromes
Primary: Left Ventricular Ejection Fraction — 1.63; 1.69; 4.42 percent of LV diastolic volume
N/A N=34 Positive Airway Pressure Program
Sleep Apnea, Obstructive
Primary: Participant Providing Feedback — 26 Participants
N/A N=25 The Role of Oxidative Stress in the Cardiovascular Consequences of Sleep Apnea
Sleep Apnea
Primary: Flow Mediated Dilation — 5.7; 9.5; 7.3 percentage change of vessel diamter — p=0.02
Early Phase 1 N=63 Respiratory and Autonomic Plasticity Following Intermittent Hypoxia
Sleep Apnea Syndromes
Primary: Ventilation (Aim 1) — 1.19; 1.14; 1.35; 1.16 fraction of baseline — p=0.001
N/A N=22 Combination Therapy to Treat Sleep Apnea
Sleep Apnea, Obstructive
Primary: Model Prediction of Absence/Presence of OSA: Ventilation That Causes an Arousal From Sleep (Varousal) — 5.7; 5.2 L/min — p=0.05
N/A N=1,325 Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure
Heart Failure · Sleep Disordered Breathing
Primary: All Cause Mortality or Unplanned Hospitalisation/Prolongation of Hospitalisation for Worsening Heart Failure — 360; 335 Participants
N/A N=9 Long QT Syndrome and Sleep Apnea
Long QT Syndrome · Sleep Apnea
Primary: QT Interval (Corrected) Baseline Visit — 453.4 square root of seconds — p=0.73
N/A N=32 Auto Continuous Positive Airway Pressure (CPAP) Based Energy Spectrum Analysis of Flow for Treatment of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)
Sleep Apnea, Obstructive
Primary: Apnea Hypopnea Index (AHI) — 2.4 events per hour
N/A N=153 Efficacy of Continuous Positive Airway Pressure in Reducing Oxidative Stress in Individuals With Sleep Apnea
Sleep Apnea Syndromes · Oxidative Stress · Cardiovascular Diseases
Primary: F2-isoprostanes/Cr — -0.02; -0.08 ng/mg — p=0.38
N/A N=144 Evaluating the Relationship Between Sleep-Disordered Breathing and Daytime Alertness
Sleep Apnea, Obstructive
Primary: Subjective Sleepiness — 11.8; 10.2; 9.9 units on a scale
N/A N=42 Sleep-Disordered Breathing in Chronic SCI
Spinal Cord Injury · Sleep Apnea, Obstructive
Primary: Cognitive Functioning as Measured by PASAT — 10.6; 15.2 score on a scale
N/A N=45 Understanding the Sleep Apnea/Insomnia Interaction
Sleep Apnea Syndromes · Sleep Initiation and Maintenance Disorders
Primary: Insomnia Severity Index Score — -8.2; -7.33; -6.27 score on a scale — p=0.8
N/A N=252 Sleep Apnea in TIA/Stroke: Reducing Cardiovascular Risk With Positive Airway Pressure
Transient Ischemic Attack · Stroke
Primary: HOMA IR Change From Baseline — 0.9; 4.0; 4.1 HOMA-IR Index
N/A N=23 Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome
Down Syndrome · Obstructive Sleep Apnea Syndrome
Primary: Change in Epworth Sleepiness Scale From Baseline to End of Study — -1; -0.5; 1 units on a scale
N/A N=45 Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography
Sleep Apnea Central · Cheyne-Stokes Respiration · Obstructive Sleep Apnea
Primary: Number of Breathing Events Identified by the Continuous Positive Airway Pressure (CPAP) Device Compared to a Simultaneous Polysomnography — 16.5; 18.1; 11.4; 11.5…
N/A N=36 Stroke and CPAP Outcome Study 3
Ischemic Stroke · Intra Cerebral Hemorrhage · Obstructive Sleep Apnea
Primary: CPAP Adherence — 3.1 nightly hours of CPAP use
N/A N=54 Diagnosis and Treatment of Sleep Apnea in the Acute Exacerbation of Heart Failure
Sleep Apnea · Heart Failure
Primary: Left Ventricular Ejection Fraction Improvement — 4.5; -.3 percent change
Phase 2 N=13 DAW1033B2 in Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA)
Primary: Apnea Hypopnea Index (AHI, Events/Hour of Sleep) — 33; 20.4 events/hour of sleep — p=0.47
N/A N=108 Obstructive Sleep Apnea in Pregnancy
Sleep Apnea, Obstructive · Pregnancy · Obesity, Morbid
Primary: Number of Participants With a Negative Obstructive Sleep Apnea (OSA) Home Sleep Test Result — 61 Participants
N/A N=40 Sleep Apnoea Breathing Record Exploratory Study (SABRES)
Sleep Apnea
Primary: Correlation Between the Trial Device and an Established Device — 0.955 correlation coefficient
N/A N=15 The Effects of Trazodone on Sleep Apnea Severity
Sleep Apnea, Obstructive
Primary: Apnea-Hypopnea Index — 38.7; 28.5 events/hour