N/A N=287 Dual Diagnosis Self-Help Referral
Dual Diagnosis
Primary: Psychiatric Functioning at 6 Months — .333; .387 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=81 Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders
Posttraumatic Stress Disorders · Combat Disorders · Alcohol Dependence
Primary: Change in Post-traumatic Stress Disorder Symptomatology — -51.2; -35.9; -22.3; -10.9 score on a scale
N/A N=279 Dismantling the Components and Dosing of CBT for Co-Occurring Disorders
CBT Decoupling · CBT Anxiety Reduction · CBT Combined
Primary: Number of Participants That Relapsed to Drinking at 4 Months — 30; 43; 35 Participants — p=.673
N/A N=102 A Brief Community Linkage Intervention for Dually Diagnosed Individuals
Schizophrenia · Psychotic Disorders · Substance-Related Disorders
Primary: Treatment Engagement — 4.2; 1.4; 7.2; 1.5 number of treatment sessions attended — p=<0.001
N/A N=254 Collaborating to Heal Addiction and Mental Health in Primary Care
Opioid-use Disorder · Mental Health Disorder
Primary: Opioid Use Other Than As Prescribed — 3.92; 0.72 Days — p=<0.001
Phase 2 N=406 Dual Diagnosis Inpatients: Telephone Monitoring RCT to Improve Outcomes
Diagnosis, Dual (Psychiatry)
Primary: Readiness to Attend Substance Use Disorder Continuing Care — 1.8; 2.2 units on a scale — p=<.05
Phase 2 N=119 Integrated Alcohol Disorder and PTSD Treatment
PTSD · Alcoholism
Primary: Clinician Administered PTSD Scale (CAPS) — 43.2; 42.1; 25.8; 32.9 score on a scale — p=.002
Phase 3 N=141 Treating Violence-Prone Substance Use Disorder Patients
Substance-related Disorders · Violence
Primary: Addiction Severity Index Legal Composite — .038; .012 units on a scale
N/A N=129 Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs
PTSD · Substance Use Disorders
Primary: CAPS Total Score Analysis Among Participants Completing at Least One Follow-up Assessment. — 77.2; 78.0; 67.5; 71.0 score on scale — p=.48
N/A N=18 Atomoxetine/Attention Deficit/ Hyperactive Disorder (ADHD)/Substance Use Disorder (SUD)in a Residential Treatment Facility
Attention Deficit Hyperactivity Disorder
Primary: Change in Adult ADHD Investigator Symptom Rating Scale Score — 17.3 units on a scale
Phase 1 N=12 Couple-Based Treatment for Alcohol Use Disorders and Post-Traumatic Stress Disorder
Alcohol-related Disorders · Post-traumatic Stress Disorder
Primary: Clinician-administered PTSD Scale (CAPS) — 58.89; 40.22 units on a scale — p=.028
N/A N=105 Neurobiology of Alcohol and Nicotine Co-Addiction
Alcohol Use Disorder · Nicotine Use Disorder
Primary: Brain Activation During Functional Magnetic Resonance Imaging (fMRI) in Response to a Stress Modulated Cue Induced Craving Task (DSNBACK) — -26.1562; -45.2123; 18.4989…
Phase 2 N=90 NAC for Treating Comorbid PTSD and SUD
Posttraumatic Stress Disorder (PTSD) · Alcohol Use Disorder (AUD) · Substance Use Disorder (SUD)
Primary: Change in Alcohol Use Disorder Severity — -2.65; -2.82 drinking days reduction
N/A N=29 Initiating Substance Use Disorder Treatment for Hospitalized Opioid Use Disorder Patients.
Opioid-use Disorder
Primary: Treatment Retention — 5; 5 Participants — p==0.87
N/A N=83 A Trauma Informed Adaptation of Mindfulness-Based Relapse Prevention for Women in Substance Use Treatment
Substance Use Disorders · Post Traumatic Stress Disorder
Primary: Recruitment — 96 Participants
N/A N=120 Adolescent Trauma Recovery and Stress Disorders Collaborative Care (ATRSCC) Model Program Trial
Post-traumatic Stress Disorder · Alcohol Abuse · Alcohol Dependence
Primary: Number of Patients With High Levels of Adolescent PTSD Symptoms — 9; 12; 11; 12 Participants — p=0.71
N/A N=131 Neurobiological Responses in Alcoholism and Early Trauma
Alcohol Use Disorder · Early Trauma Complications
Primary: Brain Response — .015; .010; -.013; .08 unitless — p=<0.05
N/A N=5,706 Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care
Substance Use Disorders · HIV · Depression
Primary: Change in Mental Health and Substance Use Screening Rates — 2008; 2379 Participants
N/A N=27 Integrated Treatment for Posttraumatic Stress Disorder and Substance Abuse in Young Adults
Substance Use Disorder · Posttraumatic Stress Disorder
Primary: Change in Severity of Posttraumatic Stress Disorder Symptoms as Measured by the National Stressful Events PTSD Scale — 1.92; 2.61 score on a scale — p=.041
N/A N=667 LINK: Aftercare Monitoring Project
Alcohol Dependence · Drug Dependence
Primary: Rates of Substance Use — 91.1; 88.0 percentage of days
Phase 4 N=96 Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders
Alcohol Use Disorder · Bipolar Disorder · Schizoaffective Disorder Bipolar Type
Primary: Baseline-to-Exit Change in Drinks Per Drinking Day (TLFB) — -1.98; -2.82; -1.22 Standard Drinks per Drinking Day
N/A N=200 Women's Treatment and Early Recovery
Substance-related Disorders
Primary: Treatment Completion — 43; 31 Number of women — p=<0.05
N/A N=183 Integrated vs Sequential Treatment for PTSD and Addiction
PTSD · Substance Addiction
Primary: PTSD Symptoms — 55.5; 54.1 units on a scale
N/A N=108 Maintaining Independence and Sobriety Through Systems Integration, Outreach, and Networking
Co-Occurring Disorders · Homelessness · Substance Abuse Disorder
Primary: Number of MISSION Sessions Undertaken — 0; 574 number of MISSION Sessions
N/A N=32 CoMBAT Opioid Use Disorder: A Combined Medication and Behavioral Activation Treatment for People Living With Opioid Use Disorder
Opioid-use Disorder · Medication Adherence · Health Care Utilization
Primary: Number of Missed Medication Doses - Past 30 Days — 3.13; 2.81; 3.71; 2.25 Number of missed doses — p=0.17
N/A N=368 Feasibility and Validation of a Standard Phenotyping Assessment Battery
Opioid-use Disorder · Cocaine Use Disorder · Marijuana Use Disorder
Primary: Retention — 4; 27; 10; 21 Participants
Phase 4 N=49 Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems
PTSD · Alcohol Use Disorder
Primary: Percent Heavy Drinking Days — 55.5; 65.1 percentage of days
N/A N=52 Prolonged Exposure Therapy for PTSD and Opioid Use Disorder
Post Traumatic Stress Disorder · Opioid-use Disorder
Primary: Change in Posttraumatic Stress Disorder (PTSD) Symptom Severity — -11.4; -12.8; -18.3 Score on a scale
Phase 2 N=69 Combined Treatment for Alcohol-Dependent Individuals With PTSD
Stress Disorders, Post-Traumatic · Alcohol Abuse · Substance-Related Disorders
Primary: Heavy Drinking Days/Week — 3.13; 2.89; 1.05; 0.48 Days/Week — p=0.34
N/A N=97 Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions
Drug Use · Alcohol Use · Congestive Heart Failure
Primary: Change in Substance Use Rates From Baseline — 51.37; 51.38; 35.53; 26.65 Days of Substance Use