N/A N=166 Study to Evaluate a Contact Lens Lubricating and Rewetting Drop
Dry Eye
Primary: Percentage of Eyes With Graded Slit Lamp Findings Greater Than Grade 2. — 1; 0 eyes
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=73 Direct Application of Systane Complete to Contact Lenses
Dry Eye · Contact Lens Complication
Primary: Difference in Ocular Surface Damage as Measured by the Brien Holden Vision Institute (BHVI Grading Scale) at Two Weeks — 0.44; 1.08; 0.83 Score on a Scale — p=0.30
N/A N=15 DAILIES TOTAL1® Lubricity Post Wear
Refractive Error
Primary: Average Coefficient of Friction (CF) at 16 Hours Compared to Unworn — 0.0394; 0.0396 unitless
N/A N=24 Lubricity Post-Wear - Competitive Lenses Pilot
Refractive Error
Primary: Average Coefficient of Friction of Worn Lenses at 16 Hours — 0.0602; 0.0576; 0.0578 unitless
Phase 3 N=246 Safety and Acceptability of Using a Rewetting Drop With Contact Lens Wear
Ametropia
Primary: Best Corrected Visual Acuity — 0.65; 1.33; 98.06; 98.67 Percentage of Participants
N/A N=369 A Safety and Effectiveness Study of a New Preservative Free Rewetting Drop
Contact Lens Wear
Primary: Overall Comfort Averaged Over All Follow-up Visits — 91.72; 91.54 units on a scale
Phase 4 N=46 Evaluation of Systane Complete for the Treatment of Contact Lens Discomfort
Contact Lens Discomfort · Dry Eye
Primary: Contact Lens Symptoms — 20.41; 18.92; 12.86; 17.92 Score on a Scale
N/A N=30 Safety and Efficacy of 2 Concentrations of Lubricin vs Sodium Hyaluronate in Ocular Discomfort After Refractive Surgery.
Ocular Discomfort
Primary: Changes From Baseline (Day 1 Pre-dose) in Ocular Tolerability Using a Visual Analogue Scale (VAS) — -22.8; -30.1; -20.9; -20.9 mm — p=0.3474
N/A N=20 Acute Comfort of Lubricant Eye Drop FID 111421
Dry Eye
Primary: Drop Comfort Upon Instillation — 1.7; 1.3 Units on a scale
Phase 1 N=31 Clinical Investigation of Visual Acuity in Contact Lens Wearers After Instillation of a Lipid- Based Lubricating Eye Drop
Visual Acuity
Primary: Visual Acuity (logMAR) at 3 Minutes Post Instillation — 0.09; 0.08 LogMAR
N/A N=29 Effect of Contact Lenses on Tear Osmolarity in a Controlled Low Humidity Chamber
Myopia · Dry Eye
Primary: Tear Osmolarity — 310; 313; 306 mOsms/L
Phase 3 N=365 A Study to Compare a New Eye Drop Formulation With Refresh Contacts®
Contact Lens Lubrication
Primary: Percentage of Participants With Contact Lens Distance Visual Acuity Change From Baseline — 11.1; 10.7; 88.9; 88.4 percentage of participants
N/A N=144 Formula Identification (FID) 114657 in Contact Lens Wearers
Refractive Error
Primary: Mean Pre-lens Tear Lipid Layer Thickness After 2 Hours of Lens Wear on Day 1 — 61.2; 61.5 ICU
N/A N=62 Contact Lens Comfort Relative to Meibomian Gland Status
Meibomian Gland Dysfunction
Primary: Comfort as Measured by the Contact Lens Users Experience Questionnaire (CLUE) — 58.67 units on a scale
N/A N=20 Acute Comfort and Blurring Profile Evaluation of Marketed Lubricant Eye Drops
Dry Eye
Primary: Drop Comfort — 0.7; 1.05; 1.84; 1.1 units on a scale
N/A N=20 Acute Comfort of Lubricant Eye Drops FID 112903
Dry Eye
Primary: Drop Comfort Upon Instillation — 1.1; 1.4 Units on a scale
N/A N=40 Tolerability, Safety and Efficacy of Lubricin Versus Sodium Hyaluronate Eye Drops in Patients With Moderate Dry Eye
Dry Eye Syndrome
Primary: Change From Baseline in Foreign Body Sensation, Burning/Stinging, Itching, Pain, Stick Feeling, Blurred Vision, Photophobia and Total Ocular Tolerability Score (VAS)…
N/A N=70 Comparative In-Vivo Wetting Characteristics of Silicone Hydrogel Materials With Selected Lens Care Systems
Myopia · Astigmatism · Refractive Error
Primary: Mean Ex-Vivo Total Lipid Uptake Per Lens — 7.198; 35.879 micrograms
Phase 4 N=30 Lifitegrast 5% for the Treatment of Dry Eye In Habitual Soft Contact Lens Wearers
Dry Eye
Primary: Efficacy of Lifitegrast Ophthalmic Solution 5% in Treating the Symptoms of Dry Eye in Contact Lens Wearers as Measured by Change in Total CLDEQ-8 Score From Baseline to…
N/A N=22 Evaluation of Silicone Hydrogel Lens Wettability With Marketed Lens Care Solutions
Contact Lens Wear
Primary: Ex Vivo Contact Angle — 104.8; 104.9; 103.3 degrees
Phase 4 N=42 The Effect of Xiidra on Comfort and Dryness in Symptomatic Contact Lens Wearers
Dry Eye
Primary: Difference in Contact Lens-related Discomfort at 12 Weeks Compared to Baseline — 71; 11 score on a scale — p=<0.01
N/A N=9 Daily Disposable Contact Lens Tear Film Study
Myopia
Primary: Number of Participants With Corrected Visual Acuity of 0.0 or Better — 9; 9; 9; 9 participants
N/A N=121 OPTI-FREE® PureMoist® for Presbyopic Contact Lens Wearers
Presbyopia
Primary: Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Score at Day 30 — 13.4; 15.8 units on a scale — p==0.0030
N/A N=61 Evaluation of Comfilcon A and Senofilcon A Lenses
Myopia
Primary: Subjective Responses for Comfort Rated on a 0-100 Visual Scale. — 86; 87; 89; 91 units on a scale
N/A N=32 Objective Testing of Tear Film Stability
Contact Lens Solutions
Primary: Objective, In-vivo Soft Contact Lens Wettability Index — -1.82; -1.98 wettability index
N/A N=14 Contact Lens Insertion and Removal in a Senior Subject Demographic
Visual Acuity
Primary: Overall Success Rate of Insertion and Removal of a Contact Lens — 85.7 Percentage of eyes
N/A N=56 Tolerability, Safety and Efficacy of Lubricin vs Sodium Hyaluronate Eye Drops in Subjects With Moderate Dry Eye
Dry Eye Syndrome · Tear Film Insufficiency
Primary: Change From Baseline (V2) in Frequency and Severity of Dry Eye Symptoms (SANDE) Questionnaire Scores at Day 28±4 (End of Treatment) — -11.9; -16.6; -25.0; -26.5 mm
N/A N=60 Dailies Total 1 Sphere Contact Lenses
Dry Eye · Contact Lens Complication
Primary: Visual Analog Scale (VAS) Contact Lenses Comfort Scores — 44 Score on a scale — p=<0.001
N/A N=48 The Effect of Systane Ultra Lubricant Eye Drops (FID 112903) on Visual Performance
Dry Eye
Primary: Time at Best Corrected Visual Acuity — 7.75; 6.42; 6.46; 5.51 seconds
Phase 4 N=51 Efficacy and Acceptability of Two Lubricant Eye Drops
Dry Eye Syndromes
Primary: Mean Frequency of Eye Drop Use Over 1 Week — 1.76; 1.66 Use per day