N/A N=238 Very-Low Nicotine Cigarettes and Non-Daily Smokers
Smoking
Primary: Change in Cigarette Consumption — -1.6; -0.05 cigarettes per day — p=<0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=93 Varenicline for Light Smokers
Smoking
Primary: Point Prevalence Smoking Outcome at 12 Weeks (End of Treatment) — 24; 7 participants — p=<0.001
N/A N=213 Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers
Cigarette Smoking-Related Carcinoma · Tobacco-Related Carcinoma
Primary: Usual Brand Cigarettes Per Day — 15.803; 2.1563; 1.8353; 1.4931 Cigarettes per Day
N/A N=369 Cessation in Non-Daily Smokers
Smoking
Primary: Smoking Cessation, Continuous 6-month Abstinence — 13; 10 Participants — p=0.46
N/A N=326 Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age
Tobacco Use Disorder
Primary: Number of Cigarettes Smoked Per Day — 22.54; 14.32; 11.76; 7.63 cigarettes per day
Early Phase 1 N=34 Nicotine Reinforcement and Aversion in Young Adult Light Smokers
Nicotine Addiction
Primary: DEQ - Pleasurable — 2.14; 2.05; 1.98; 2.37 score on a scale
N/A N=29 Electronic Cigarette Use in Young Adult Men and Women
Cigarette Smoking · Tobacco Use
Primary: Contextual Factors Associated With Tobacco Use Episode Reported Via Ecological Momentary Assessment — 3; 22; 11; 12 tobacco use episodes — p=0.002
N/A N=139 Cigarette Smoking Among Young Adults
Cigarette Smoking · Smoking Behaviors
Primary: Puff Topography — 1108; 1045.2; 1084.6 mL
N/A N=10 IQOS (Non-Cigarette Tobacco Product) Pilot Study
Smoking · Tobacco Use
Primary: Number of Participants Who Prefer IQOS — 7 Participants
Phase 3 N=74 Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day
Tobacco Use Disorder
Primary: Feasibility as Indicated by Self-reported Adherence to Study Cigarettes. — 7.1; 7.3; 10.4; 13.3 Percent non-study cigarettes per day
N/A N=40 Acute Effects of Cigarette Packaging and Charcoal Filtration on Perceptions, Use Behaviors, and Harm Exposure
Smoking Behaviors
Primary: Number of Puffs Taken (Video-scored Smoking Behavior Outcome 1) — 15.8; 16.7; 19.1; 19.6 puffs
N/A N=30 Quit or Switch: E-cigarette Study
Tobacco Use
Primary: Percentage of Participants Who Report Daily Use of E-cigarettes or NRT and no Cigarette Use
N/A N=149 tDCS Effects on Resisting Smoking: Dose Ranging Study
Nicotine Addiction
Primary: Resisting Smoking - Time to First Cigarette in the Resist Smoking Paradigm — 60.3; 63.4; 63.2 minutes — p=0.94
Phase 2 N=326 Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
Tobacco Use Disorder
Primary: Cigarettes Per Day — 22.54; 14.32; 11.76; 7.63 cigarettes per day
N/A N=5 Effects of Smoking State on Decision Making
Behavior
Primary: Effort Based Decision Making — 29.5; 18.3 high effort selections
N/A N=22 Comparative Abuse Liability Among African American and White Smokers
Tobacco Use Disorder
Primary: Nicotine Delivery — 14.13; 6.79; 9.15 ng/mL — p=0.002
N/A N=184 Brain Nicotine Receptor Density in Veteran Smokers
Positron Emission Tomography
Primary: PET Scan, Rating Scales — 7.1; 8.6; 7.9; 8.0 Vt/fp or mL/cm3
Phase 2 N=326 Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder
Tobacco Use Disorder
Primary: Number of Cigarettes Smoked Per Day — 22.54; 14.32; 11.76; 7.63 cigarettes per day
Early Phase 1 N=102 The Effects of IQOS Use on Cigarette Smoking Behaviors
Smoking · Cigarette Smoking · Tobacco Use
Primary: Cigarette Consumption — 31.68 percentage of baseline smoking rate
N/A N=150 Methods Project 4: Clinical Trial
Smoker
Primary: Smoke-free Days — 14.5; 0; 0 days
N/A N=33 Impact of Switching to Non-Menthol Cigarettes Among Smokers
Tobacco Use
Primary: Total Number of Cigarettes Smoked — 2.2 cigarettes per day
N/A N=31 JUUL vs. Mod E-cigarette Study
Smoking · Tobacco Use
Primary: Choices to Smoke — 26.15; 30; 38.33 Percentage of Total Choices
N/A N=22 Assessment of Two New Electronic Cigarettes in Cigarette Smokers
Electronic Cigarettes
Primary: Change in Plasma Nicotine — 7.62; 10.65; 18.31; 7.19 ng/ml
Phase 2 N=30 Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women
Tobacco Use Disorder
Primary: Total Cigarettes Per Day — 16.31; 18.36 Cigarettes per day
N/A N=50 Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors
Smoking
Primary: Total Cigarettes Smoked Per Day — 21.6; 7.7; 18.4; 12.5 number of cigarettes
N/A N=60 Smoking Topography and Harm Exposure in Menthol Cigarettes
Cigarette Smoking Toxicity
Primary: Smoking Topography- Puff Volume — 518; 661; 650; 620 mL
N/A N=30 Switching to Potential Reduced Exposure Products in Adult Smokers
Tobacco Use Disorder · Oral Nicotine Pouch Use · Smoking Behaviors
Primary: Number of Cigarettes Smoked Per Day (Log-transformed) — 2.0; 1.8 number of cigarettes smoked
N/A N=142 A Study to Assess Changes in Cigarette Consumption During a Switch to Very Low Nicotine Cigarettes
Tobacco Use
Primary: Cigarettes Per Day — 14.75; 17.19; 15.76; 16.29 Cigarettes Per Day (CPD)
N/A N=24 User Acceptability of a Nicotine Lactate Delivery System (P3L)
Smoking
Primary: Change From Baseline Plasma Concentration of Nicotine/Cotinine After Each ad Libitum Use Session. — 1.7621; 2.4113; 1.9446; 5.5571 (ng/mL)
N/A N=80 Low Nicotine Cigarettes Plus Electronic Cigarettes
Tobacco Dependence
Primary: Urinary NNAL (4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol) — 505.6; 459.1; 373.3; 180.5 pg/mg creatinine — p=0.017