Clinical Trial Search

Primary: Headache Severity 2 Hours Post Treatment — 2.18; 2.09; 0.85; 1.17 units on a scale

Primary: Number of Participants With Adverse Events (AEs), Serious AEs, and AEs Leading to Study Discontinuation — 13; 6; 8; 21 Participants

Primary: Severity of Affective Lability Based on Shortened Agitated Behavior Scale — 9.22; 9.39 units on a scale

Primary: Efficacy of Side Effect Prevention Using the Acute Hangover Scale — 6.7; 4.7; 7.8; 6.8 score on a scale

Primary: 0-10 Pain Scale on Which 0 = no Pain and 10= the Worst Pain Imaginable — 5.2; 3.8 units on a scale

Primary: Percentage of Patients With Significant Pain Reduction — 90.3 percentage of participants

Primary: Pain Intensity — 5.82; 4.92 score on a scale

Primary: Number of Participants With Sustained Headache Relief — 12 Participants

Primary: Self-reported Residual Effects of Heavy Drinking — 4.3; 1.93 scores on a scale

Primary: Negative Affect — 2.91; 2.47 units — p=.62

Primary: Frequency of Moderate or Severe Headache After Emergency Department (ED) Discharge — 31; 29; 42; 44 Participants — p=0.751

Primary: Change in Headache Days/Month After 4 Years Compared to Baseline — 6.6 headache days/month

Primary: Change in Headache Relief — 23 percentage of headaches resolved — p=.079

Primary: Change in Pain Score at 60 Minutes — 4; 5 score on a scale

Primary: Pressure Pain Threshold — 4.56; 5.27; 3.81; 4.51 lbf — p=.99

Primary: Frequency of Headaches — 10 Participants — p=.101

Primary: Hangover Symptom Scale — 10; 13; 1; 1 units on a scale — p=0.45

Primary: Ratio of Glutamate to Creatine in the Anterior Cingulate of the Brain, Measured on Day 4 — 1.256772; 1.294178 Ratio of glutamate to creatine

Primary: Number of Subjects With Daily Headache Who Have Continuous Headache — 18; 27 participants

Primary: Total Sleep Time — 5.4; 5.5; 6.3; 6.1 hours — p=0.33

Primary: Numerical Rating Scale — 4.1; 4.3 units on a scale

Primary: Number of Participants With Adequate Relief of Headache as a Measure of Efficacy — 34; 32 Participants — p=0.14

Primary: Peak Number of Alcohol Drinks Consumed in a Day — 3.7; 4.2; 3.4; 3.0 drinks — p=.81

Primary: Number of Participants With Sustained Headache Relief Assessed by Self-evaluation — 40; 38 Participants

Primary: Number of Headache Days — 4; 3; 3; 4 number of headache days

Primary: Number of Participants Who Report Moderate or Severe Pain Within 24 Hours of Emergency Department(ED) Discharge — 53; 6; 20 Participants

Primary: Time to Relief (Min) — 92.2; 83.9; 35.4 Minutes

Primary: Change in Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Subscales of the Drug Effects Questionnaire Across Sessions…

Primary: Persistent Headache Pain Free at 24 Hours — 26; 19 Participants

Primary: Treatment Adherence — 15 Participants