Clinical Trial Search

Primary: Change in Dopamine Levels at Baseline and After Drug of Dependence Administration as Confirmed by PET Images. — 0.0388; 0.033; 0.0285; 0.0368 mm^3

Primary: Hopkins Verbal Learning Test (HVLT) Total Recall — 17.27; 18.00; 15.27; 17.50 units on a scale

Primary: Retention Without Relapse to Heroin Addiction (Measured at Month 6) — 54; 16; 11 Participants

Primary: The Percentage of Opiate- and Cocaine-negative Urine Samples — 44.9; 64.6 percentage of urine samples — p=.05

Primary: Proportion of Patients Abstinent From Marijuana During Weeks 7 and 8 of the Trial — 14; 12 participants

Primary: Regional Availability of Metabotropic Glutamate Type-5 Receptors (mGluR5) — 36.48; 32.19; 25.67; 22.41 mL*cm^3 — p=0.035

Primary: PARS Help-Seeking Scale — 0.57; 0.53 units on a scale

Primary: TB Treatment Completion Rates in Prison — 114; 127 Participants — p=0.08

Primary: Number of Participants With New Crime — 5; 3 Participants

Primary: Number of Participants With Drug Use at 3 Months — 49; 48 participants

Primary: Number of Cocaine Non-use Days — 10.1; 17.1; 9.3; 14.1 Number of Days

Primary: Percentage of Positive Toxicology Swabs for Illicit Substances — 81.3; 79.1; 86.2; 82.3 percentage of positive toxicology screen

Primary: Abstinence — 71.4; 16.6 percentage of participants

Primary: Alcohol Abstinence — 82.8; 60.2 percentage of participants — p=<0.001

Primary: Illicit-positive Urines During Treatment and Follow-up — 0; 0; 1; 1 Participants

Primary: Percentage of Monthly Urine Samples That Are Negative for Cocaine — 51.8; 79.3 percentage of urine samples — p=.004

Primary: Change in Average Waiting Time From First Contact to Treatment — .253; 4.610; 4.723; 3.520 Change in days

Primary: % Cocaine-Negative Urine Specimens Per Participant — 42.2; 59.1; 51.0 % negative specimens per participant — p=0.177

Primary: Brain Activation During Functional Magnetic Resonance Imaging (fMRI) in Response to a Stress Modulated Cue Induced Craving Task (DSNBACK) — -26.1562; -45.2123; 18.4989…

Primary: 11C-UCB-J PET Synaptic Density — 4.01; 4.52; 4.62; 5.09 unitless — p=0.011

Primary: the Adult ADHD Rating Scale (AARS) (30% Reduction) — 50 percent of participants

Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 0.06; 0.94; 0.75; 0.88 cocaine choices

Primary: Longest Duaration of Achieved Abstinance — 0; 7; 1; 8 number of participants

Primary: Treatment Retention — 5; 5 Participants — p==0.87

Primary: Recruitment Feasibility — 10 participants per month

Primary: Cocaine Use (Measured by Timeline Follow Back and Urine Screen From Week 2-week 14) — 9.3; 7.2; 10.1; 10.5 number of cocaine negative urine samples

Primary: Visual Analog Scale Subjective Rating of Drug Effects — 8.65; 9.85; 13.65; 10.43 units on a scale

Primary: Marijuana Abstinence (2 Weeks or Greater) — 72.5; 68.6; 45.1 percentage of participants

Primary: %BMIp95 — -1.9; -1.2; -1.5 percent

Primary: Proportion of Cocaine Positive Urine Samples Per Treatment Condition — 45.4; 42.7; 53.5; 46.5 percentage of positive urine samples — p=0.531