N/A N=100 Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy
Tobacco Use Disorder · Smoking
Primary: Changes in the Number of Cigarettes Per Day (CPD) — 8.2; 7.3 cigarettes per day (CPD)
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=80 Low Nicotine Cigarettes Plus Electronic Cigarettes
Tobacco Dependence
Primary: Urinary NNAL (4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol) — 505.6; 459.1; 373.3; 180.5 pg/mg creatinine — p=0.017
N/A N=38 Clinical Pharmacology of Electronic Cigarettes
Nicotine Dependence
Primary: Standardized Session: Mean CMax — 6.1; 20.2 ng/mL
N/A N=27 Effects of Electronic Cigarettes on Nicotine Concentrations
Health Behavior
Primary: Effects E-cig Use on Venous Nicotine Concentrations Before and 5 Minutes After Use — 4.30; 4.11; 8.66; 8.77 ng/ml
N/A N=64 Cigarette and E-cigarette Nicotine Content in an Electronic Tobacco Marketplace (ETM)
Tobacco Use
Primary: Number of Cigarettes Purchased — 154.7; 119.2 average number of cigarettes
N/A N=45 Effects of Electronic Cigarette Settings and Liquid Concentrations in Cigarette Smokers and Electronic Cigarette Users
Electronic Cigarettes
Primary: Change in Plasma Nicotine — 8.68; 8.28; 9.53; 12.00 ng/ml
N/A N=68 A Trial of E-cigarettes in Current Cigarette Smokers
Smoking · Nicotine Dependence · Nicotine Dependence, Other Tobacco Product
Primary: Uptake of Electronic Nicotine Delivery Systems (ENDS) — 57.14; 32; 13.64 percentage of participants
N/A N=213 Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers
Cigarette Smoking-Related Carcinoma · Tobacco-Related Carcinoma
Primary: Usual Brand Cigarettes Per Day — 15.803; 2.1563; 1.8353; 1.4931 Cigarettes per Day
N/A N=51 Effect of the Electronic Cigarette on Withdrawal Symptoms
Mental and Behavioral Disorders · Withdrawal State
Primary: Comparison of E-C and Inhalator in Effects on Withdrawal Over 24 Hours of Use. — 0.73; 0.86 units on a scale — p=0.17
N/A N=22 The Effect of Electronic Cigarette Liquid Characteristics in Smokers.
Electronic Cigarettes
Primary: Plasma Nicotine Concentration — 12.32; -0.22; 7.09; 5.85 ng/ml
N/A N=29 Electronic Cigarette Use in Young Adult Men and Women
Cigarette Smoking · Tobacco Use
Primary: Contextual Factors Associated With Tobacco Use Episode Reported Via Ecological Momentary Assessment — 3; 22; 11; 12 tobacco use episodes — p=0.002
N/A N=12 A Bioavailability Study of Nicotine Delivered by an Electronic Vapour Product
Healthy Volunteers
Primary: Nicotine Plasma Concentration — 3.6; 2.5; 2.5; 21.2 ng/ml
N/A N=33 Assessing Electronic Cigarette Nicotine Flux
Electronic Cigarette Use
Primary: Plasma Nicotine Concentration — 2.00; 1.92; 1.64; 1.62 mg/ml
N/A N=40 Smoking Cessation and Reduction With an Electronic Nicotine Delivery Device (ENDD)
Nicotine Dependence · Smoking Cessation
Primary: Sustained 50% Reduction in the Number of Cig/Day at Week-24 From Baseline (Reducers) — 13 number of participants
N/A N=22 Assessment of Two New Electronic Cigarettes in Cigarette Smokers
Electronic Cigarettes
Primary: Change in Plasma Nicotine — 7.62; 10.65; 18.31; 7.19 ng/ml
N/A N=15 Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening
Electronic Cigarette Use · Smoking, Cigarette · Nicotine Dependence
Primary: Study Feasibility — 15 Participants
Phase 2 N=94 The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products
Nicotine Dependence, Cigarettes
Primary: Expired Air Carbon Monoxide (CO) to Assess Recent Smoking — 18.3; 22.9; 21.3; 25.6 Parts per million (ppm) — p=0.01
Early Phase 1 N=62 Responses to E-Cigarette Advertising
E-Cig Use
Primary: Attention to Specific ad Feature — -1.7062; -0.9676; -1.8238 Beats per minute
N/A N=234 Changes in Biomarkers Associated With Use of Electronic Cigarettes
Biomarkers
Primary: Change in Biomarker Concentrations: Nicotine Equivalents — 74.9; 79.56 mmol/mg creatinine
N/A N=17 E-cigarettes for Harm Reduction in Adults With Asthma
Smoking · Asthma · Electronic Cigarette Use
Primary: Change in Cigarettes Per Day From Baseline to Week 8 and Week 16 — 16.34; 15.39; 9.51; 8.66 cigarettes per day — p=.004
N/A N=57 The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
Nicotine Dependence
Primary: Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' — 5.1979; 6.8384; 5.6235; 7.6285 scores on a scale — p=<.0001
N/A N=104 Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers
Tobacco Dependence
Primary: Urinary NNAL Concentration — 151.6; 338.2 ng/ml — p=0.0039
N/A N=209 A Study to Evaluate the Safety of Electronic Vapor Products for 2 Years
Healthy Volunteers
Primary: Blood Pressure — 122.4 mmHg
N/A N=7 E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia
Tobacco Smoking
Primary: Change in Smoking as Assessed by Breath Carbon Monoxide Levels — -18; -4.3 parts per million (ppm)
N/A N=30 Quit or Switch: E-cigarette Study
Tobacco Use
Primary: Percentage of Participants Who Report Daily Use of E-cigarettes or NRT and no Cigarette Use
N/A N=408 A Study to Evaluate the Safety Profile of an e-Vapour Product
Healthy Volunteers
Primary: Adverse Events — 1.60; 0.79 percentage of adverse events
N/A N=60 Predictors and Consequences of Combustible Cigarette Smokers' Switch to Standardized Research E-Cigarettes
Tobacco Use
Primary: Combustible Cigarette Use — 3.79; 3.64 Number of cigarettes smoked per day
Phase 3 N=25 Combination of E-cigarettes and Varenicline for Tobacco Harm Reduction
Smoking Cessation · Harm Reduction
Primary: Number of Participant Reporting Continuous Complete Switching From Cigarettes to Halo G6 — 8 Participants
N/A N=372 Examination of Low Wattage and High Wattage E-Cigarettes
Smoking, Cigarette · Smoking, Tobacco · Nicotine Dependence
Primary: Complete Change From Conventional Cigarettes - Self Report — 0; 12; 10; 0 Participants
N/A N=37 Menthol Flavored E-cigarette Use During a Simulated Ban of Menthol Cigarettes
Tobacco Use Disorder
Primary: Number of Cigarettes Smoked Per Day — 2.2; 1.8; 6.0; 7.1 model estimated cigarettes per day