N/A N=520 Study of Lung Cancer in Appalachian Kentucky: The Role of Environmental Carcinogens
Lung Cancer
Primary: Rate of Moderate to High Arsenic Level in Cases and Controls — 0.04; 0.04 mcg/dL
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=300 Evaluation of the Role of Aflatoxin as an Environmental Risk Factor Attributable to Liver Cancer in Nile Delta
Liver Cancer
Primary: Serum Aflatoxin Level in Liver Cancer Patients — 7.96; 6.10; 4.13 ng\ml
N/A N=14 Pharmacotoxicology of Trichloroethylene Metabolites
Congenital Lactic Acidosis
Primary: Hypothesize That Subject's Genotype Will Determine How DCA is Metabolized. — 1592; 232 Minutes — p=0.023
N/A N=281 Oral Cell DNA Adducts in Smokers
Lung Cancer
Primary: Concentration of γ-OH-Acr-dGuo, a Major Acrolein-DNA Adduct — 49.7; 67.1; 46.5 10^9 nucleotides/mL
Early Phase 1 N=8 Benzo[a]Pyrene Ultralow Dose-Response Study
Environmental Exposure
Primary: Peak Plasma Concentration Cmax — 2.51; 5.68; 13.8; 8.99 fg [14C]-BaP/mL plasma
Phase 2 N=300 Clinical Trial of Two Study Drinks in Detoxification of Environmental Toxicants and Carcinogens
Healthy
Primary: Carcinogen Detoxification of Metabolites in Urine. — 7.26; 6.11; 3052.39; 1843.29 ng/mL
N/A N=299 Nucleophilic Defense Against PM Toxicity (NEAT Trial)
Air Pollution Toxicity
Primary: Endothelial Progenitor Cells — 0.0025; 0.0027 # cells per CD41 minus cells
Phase 2 N=170 Broccoli Sprout Dose Response: Bioavailability and Effects of Air Pollutants
Environmental Carcinogenesis
Primary: Sulforaphane Bioavailability Measured in Sequential 12-Hour Urine Samples — 24.8; 11.0; 4.3 micromoles/24 hours — p=<0.001
N/A N=16 Metabolism of NNK in Japanese Americans
Smoking
Primary: The Ratio of D4-hydroxy Acid to D4- NNAL (an Estimate if NNK Alpha Hydroxylation) — 0.133; 0.175 Ratio
N/A N=434 Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals in Adults of Child-Bearing Age
Endocrine Disrupting Chemicals · Environmental Exposure · Health Literacy
Primary: Changes in Endocrine Disrupting Chemical (EDC) Levels as Measured by the Post-intervention Value Minus the Baseline Value. — 5.83; 18.43; 56.94; 75.30 ng/ml — p=<0.05
Early Phase 1 N=8 Ultralow Dose PAH Binary Mixture Study
Environmental Exposure
Primary: Peak Plasma Concentration of 14C-BaP Cmax — 7.07; 1.60 fg [14C]-BaP/mL plasma
Early Phase 1 N=7 Pharmacokinetics of Benzo[a]Pyrene: Impact of Diet
Environmental Exposure
Primary: Peak Plasma Concentration of 14C-BaP Cmax — 3.69; 1.67; 0.68 fg [14C]-BaP/mL plasma
N/A N=24 Evaluation of Post-Exposure Sauna Treatment of Firefighters - A Pilot Study
Post-fire Rehabilitation of Firefighters in Sauna
Primary: Urinary Excretion of Hydroxylated PAHs (PAH-OHs) — 10364.2; 40012.1; 6964.1; 22604.3 ng/L — p=0.0000009
N/A N=61,175 Carcinogenicity Study of Bupropion
Depressive Disorder · Cancer
Primary: Number of Participants Diagnosed With Any of the Cancers Under Investigation Who Were Regularly Exposed to the Indicated Antidepressant — 853; 4561; 1963; 2570…
Phase 2 N=291 Broccoli Sprout Intervention in Qidong, P.R. China
Environmental Carcinogenesis
Primary: Effect of Treatment on Levels of Air Toxics Mercapturic Acids Over Intervention Period — 1.700; 1.065 pmol/mg creatinine
Phase 2 N=25 Phase 2 Study of Atorvastatin Safety and Antitumor Effects in Non-Hodgkin's Lymphoma
Leukemia · Lymphoma, Non-Hodgkin
Primary: Tumor Apoptosis — 7 Participants
Early Phase 1 N=49 Broccoli Sprout/Broccoli Seed Extract Supplement in Decreasing Toxicity in Heavy Smokers
Cigarette Smoking-Related Carcinoma · Tobacco-Related Carcinoma
Primary: Change in Urinary Excretion of the Mercapturic Acid of Benzene Following 4 Tablets Per Day of Avmacol — 1.16 data presented as ratio; no unit
N/A N=37 Cigarette Smoking Decision Study
Tobacco Smoking
Primary: Demand Intensity as Assessed by a Behavioral Economic Demand Curve — 4.709677419; 2.580645161 puff bouts
N/A N=81 Correlation Between Skin Carotenoid Levels and Previous History of Skin Cancer
Skin Cancer · Basal Cell Carcinoma · Squamous Cell Carcinoma
Primary: Skin Carotenoid Levels in Subjects With History of Squamous Cell Carcinoma Versus Control Subjects — 27,635; 31,219 Raman spectroscopy intensity counts — p=0.31
N/A N=402 HCC Screening Using DNA Methylation Changes in ctDNA
Hepatocellular Carcinoma
Primary: Calculation of M Scores and HCC Probability Scores — 1.113; 1.159; 1.797; 1.707 units on a scale
Early Phase 1 N=28 Intervention to Reduce Body Burdens of PCBs in Residents of Anniston, Alabama
Toxic Effect of Other Corrosive Organic Compounds
Primary: Percent Change From Baseline for Total PCB Levels — 92; 96 % of baseline total PCBs
Phase 2 N=1,075 Green Tea and Reduction of Breast Cancer Risk
Breast Cancer
Primary: Mammographic Density — 22.71; 21.84; 22.09; 21.13 Percent
Phase 2 N=42 Chemoprevention Trial - Anastrozole in Ductal Carcinoma In Situ (DCIS) in Postmenopausal Women
DCIS
Primary: Number of Participants With a Change in Ki-67 Level — 15; 5; 3 Participants — p=0.004
Phase 2 N=107 Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers
Lung Cancer · Tobacco Use Disorder
Primary: Urinary Levels of Biomarkers of NNK Metabolism — 42.8; 0.36; 0.28; 49.7 pmol/mg creatinine
N/A N=15 Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening
Electronic Cigarette Use · Smoking, Cigarette · Nicotine Dependence
Primary: Study Feasibility — 15 Participants
N/A N=136 COMET Study 1: Filter Ventilated Cigarette Substitution in the ETM
Substance-Related Disorders
Primary: High Ventilated Cigarette Purchases — 104.22; 29.64; 52.38; 47.41 single unit quantity purchased
N/A N=68 Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
Nicotine · Vaping · Nicotine Vaping
Primary: 3-HPMA — 657.46; 726.84; 703.29; 724.06 ng/mg creatinine
N/A N=93 Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia
Oral Epithelial Dysplasia, Mild or Moderate Grade
Primary: The Number of Participants With Both Clinical and Histological Evidence of Malignant Transformation of Oral Epithelial Dysplasia — 32; 46 participants
Phase 2 N=45 A Study of Chemo +/- Low-dose Radiation as Induction Therapy in SCCHN
Head and Neck Cancer · Larynx
Primary: Primary Site Complete Response Rate — 6; 4 Participants
N/A N=39 DRIIVE (Data and Research on Interventions to Improve the Vehicular Environment)
Vehicular Environment
Primary: Collect Preliminary Data on In-vehicle Excess Particulate Matter (PM) Exposure