Phase 3 N=46 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
Aggressive Periodontitis
Primary: Change in Clinical Attachment Level (CAL) — 3.69; 3.62; 2.4; 3 mm
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Phase 4 N=42 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients
Aggressive Periodontitis
Primary: Probing Depth — 4.55; 4.80; 4.90; 2.71 mm — p=<0.01
Phase 4 N=39 Alternative Antibiotic Regime in the Treatment of GAgP
Generalized Aggressive Periodontitis · Aggressive Periodontitis
Primary: The Primary Outcome Variable Was Probing Depth. — 4.57; 4.18; 3.12; 2.91 mm — p=<0.01
N/A N=40 Clarithromycin as Adjuvant to Periodontal Debridement
Aggressive Periodontitis
Primary: Clinical Attachment Level — 2.71; 3.03 milimeter
N/A N=69 IFI16 is a Periodontitis Modulating Protein
Severe Periodontitis · Acute Inflammatory Response
Primary: Change in Absent in Melanoma 2 (AIM2) mRNA Expression Levels — 0.37; 0.65 fold change — p=0.3
Phase 3 N=38 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis
Aggressive Periodontitis
Primary: Change in Probing Depth — 3.88; 3.74; 3.38; 3.26 milimeters — p=<0.05
N/A N=60 Activated MMP-8 as Diagnostic Test for Periodontitis
Generalized Chronic Periodontitis
Primary: Percentage of True Positive/Negative aMMP-8 Tests of All Periodontitis Patients (Sensitivity/Specificity) — 87; 60 percentage of true cases (sens./spec.)
Phase 3 N=39 Collection of Gingival Crevicular Fluid From Periodontitis Patients
Gingival Diseases
Primary: Metabolite Associated With Inflammation (Cadaverine) — 1.119186; 0.92077 ion count — p=<0.05
Phase 4 N=113 Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population
Periodontal Disease · Type 2 Diabetes Mellitus
Primary: Glycated Hemoglobin A1c — 8; 8.2 percentage of Glycated Hemoglobin A1c
Phase 3 N=34 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
Residual Disease · Aggressive Periodontitis
Primary: Clinical Attachment Level at Baseline, 3 Months and 6 Months — 5.5; 5.29; 4.64; 4.73 mm
N/A N=5,117 Periodontal Disease Prevention Study
Periodontitis
Primary: Percentage of Participants With Tooth Loss Over 16 Year Period — 16.4; 13.8; 22.1; 16.9 percentage of participants
Phase 4 N=51 Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
Periodontitis
Primary: Periodontal Probing Depth — 2.5; 3.2; 3.4 millimeter
N/A N=17 Cytokines in Papillon-Lefèvre Syndrome
Papillon-Lefevre Disease
Primary: Serum Concentrations of Interleukin (IL)-1 Beta — 1100.00; 896.21; 65559; 45734 pg/ml
N/A N=51 Kidney and Periodontal Disease Study
Chronic Kidney Disease · Periodontal Disease
Primary: Number of Participants Completing Study Protocol — 17; 34; 14; 30 Participants
N/A N=59 Study to Compare Laser Assisted New Attachment Procedure (LANAP) to Traditional Treatments of Chronic Periodontitis
Chronic Periodontitis
Primary: Gain in Clinical Attachment Level of Periodontal Tissues — 1.361; 2.387; 1.180; 2.329 mm
N/A N=38 Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy
Periodontitis
Primary: Change in Pocket Probing Depth (PPD) — 3.932; 4.082; 3.253; 3.294 mm
Phase 4 N=30 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis
Localized Aggressive Periodontitis
Primary: Assessment of Change in Clinical Attachment Level (CAL) — -14.07; -37.48 percentage of change
N/A N=48 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3
Gingival Bleeding · Von Willebrand Diseases
Primary: Bleeding on Probing (BOP) — 14.5; 12.3 percentage of sites
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
N/A N=40 Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease
Periodontal Diseases
Primary: Change in Number of Bleeding Sites (Bleeding On Probing) — -1.60; -1.40 bleeding sites
N/A N=34 Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels
Chronic Peridontitis Patients · Chronic Gingivitis · Healthy
Primary: Pocket Depth — 1.60; 2.50; 6.75 millimetres
Phase 2 N=146 Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers
Periodontitis · Periodontal Diseases
Primary: Change in Mean Clinical Attachment Level. — 0.11; 0.10; 0.21; 0.08 mm — p=>0.05
N/A N=88 GUIDOR® Growth Factor Enhanced Bone Graft Substitute for the Treatment of Periodontal Defects 6-months Post-Surgery
Alveolar Bone Loss · Periodontal Diseases
Primary: Number of Participants That Met the Success Criteria of Radiographic and Clinical Measurements — 16; 15; 19; 17 Participants
Phase 2 N=114 Impact of Periodontal Therapy on Patients With Diabetes
Diabetes Mellitus, Type II · Periodontitis
Primary: Change in Probing Pocket Depth at the 6-month Post-SRP Completed at Baseline — -0.25; -0.18 mm — p=0.16
Phase 3 N=602 Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis
Adult Periodontitis
Primary: Change in Pocket Depth. — -1.4; -1.6; -1.4 mm
N/A N=34 Investigation of the Safety and Efficacy of Pocket-X Gel
Periodontal Pocket
Primary: Change in Periodontal Pockets Probing Depth — 6.97; 6.81; 7.67; 7.72 mm
N/A N=32 Induced Gingivitis & Intra-oral Imaging
Plaque Induced Gingivitis
Primary: Change From Baseline Gingivitis at Day 14 as Measured by Non-invasive Microimaging and Gingival Index. — 0.6; 0.15 units on a scale
N/A N=41 Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans
Periodontitis
Primary: Change in Clinical Attachment Level (CAL) — 1.21; 1.03 mm
Phase 4 N=70 Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg
SRP · Minocycline HCl Microspheres · Biomarkers
Primary: Bacteria Load (log10) — -11.3; -10.9 log 10 copies/mL
N/A N=44 Lactobacillus Reuteri in the Supportive Therapy of Periodontitis
Periodontal Diseases
Primary: Change in PD (Periodontal Depth) — 5.63; 5.45; 4.01; 4.03 millimeter