N/A N=22 Characterization of Transient Alterations of Cutaneous Sensory Nerve Function by Cryolipolysis
Adiposity
Primary: Vibration Detection Threshold (VDT) — 26.3; 19 (um/sec)
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=30 Probe Configuration and Time-Temperature Dose Ranging for Understanding of Skin Lesion Effects
Histological Response of Tissue to Cold
Primary: Biological Tissue Response
N/A N=28 Does Cold Provocation Increase Brown Adipose Tissue Volume?
Brown Adipose Tissue, Human
Primary: Brown Adipose Tissue, Absolute Volume — 0.0066; 0.0021 liters
N/A N=12 Impact of Muscle Temperature on Muscle Growth and Breakdown: Cooling During Resistance Training
Exercise Training
Primary: RT-qPCR for Forkhead Box O3 (FOXO3a) — 1.24; 1.30 fold change — p=.609
N/A N=40 Effect of Prewarming on Microcirculatory Response
Coronary Artery Bypass Graft Triple Vessel
Primary: Recovery Slope — 2.8; 3.1 % / sec (recovery slope unit)
N/A N=19 Tissue Optimization on Cryolipolysis Procedures for Fat Layer Reduction
Body Fat Disorder
Primary: Percentage of Before and After Side-by-side Photographs Correctly Identified by At Least 2 of 3 Blinded Reviewers From the Independent Physician Reviewer (IPR) Panel…
N/A N=12 Breast/Evaluation of Cryotherapy and TRPA1 Receptors in Chemotherapy Induced Neuropathy
Peripheral Neuropathies
Primary: Prevention of Peripheral Neuropathy During Taxane Chemotherapy — 7.28 score on a scale
N/A N=32 Different Cryocompression Devices and Skin Temperature of the Knee
Temperature Change, Body
Primary: Skin Temperature — 31.18; 31.21; 31.1; 31.93 degrees celsius
Phase 2 N=10 Histopathology Following CCH Injection
Characteristics of Subcutaneous Tissue
Primary: Number of Participants With a Histologic Change in a Tissue Specimen That Was Injected With CCH — 2; 1; 1; 2 Participants
N/A N=141 Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
Cardiac Arrest
Primary: Survival Rate - Number of Participants Alive — 55; 20; 32; 34 Participants — p=<0.001
N/A N=175 Non-Invasive Cooling of Fat Cells
Reduction of Unwanted Fat
Primary: Percentage of Participants With Visible Improvement in Treated Area — 65.2; 82.8 percentage of participants
N/A N=738 Use of Hypothermia During Robotic Prostatectomy
Prostate Cancer
Primary: Feasibility and Safety Using an Improved, More Efficient and Less Labor Intensive Cooling Balloon in Patients Undergoing Hypothermic Nerve-sparing RLP in Participants…
N/A N=22 Cryolipolysis and Subcision for Treatment of Cellulite
Cellulite
Primary: Blinded Rating of the Treatment Area (Cryolipolysis vs. Subcision) With the Best Cosmetic Appearance. — 22.22; 33.33; 44.44 Percentage of participants
N/A N=60 Non-invasive Cooling of Subcutaneous Fat
Fat Disorder
Primary: Change in Fat Layer Thickness of the Treated Flank — -18.7; -22.6; -17.8; -17.5 percent fat layer change
Phase 4 N=30 Body Temperature in Persons With Tetraplegia When Exposed to Cold
Tetraplegia · Hypothermia · Mild Cognitive Impairment
Primary: Visit 1: Percent Change in Core Body Temperature — -1.2; 0.05 Percent Change — p=<0.01
N/A N=10 CrYobiopsy With Radial UltraSound Guidance
Pulmonary Disease
Primary: Time to Achieve Hemostasis After Obtaining Cryobiopsy — 146.55; 132.25 seconds — p=0.7878
N/A N=66 Histological Evaluation of Healing Following Ridge Preservation Using a Combined Cortical/Cancellous Mineralized Freeze-Dried Bone Allograft
Alveolar Bone Loss
Primary: % Vital Bone Formation (Histological) — 26.4; 24.5; 28.8 percentage of total area
N/A N=30 Image-guided Cryoablation of Head, Neck and Spine Tumors
Head and Neck Neoplasms · Malignant Neoplasm of Vertebral Column
Primary: Number of Participants Undergoing Image-guided Cryoablation of a Head, Neck, or Spine Tumor With Adverse Events — 3; 0 participants
N/A N=51 Safety of a Sheath Cryoprobe Bronchoscopic Transbronchial Biopsy Technique
Lung Diseases
Primary: Number of Participants With Serious Adverse Events — 0 Participants
N/A N=84 The cryoICE™ CryoAnalgesia Study For Pain Management in Post thoRacic Procedures Via intercOSTal Cryoanalgesia (FROST)
Pain
Primary: Primary Outcome 1: Forced Expiratory Volume (FEV1) at 48-Hours Post-Surgery — 1.2; 0.93 Liters (L) — p=0.0223
Phase 4 N=30 Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia
Tetraplegia · Hypothermia · Mild Cognitive Impairment
Primary: Change in Core Body Temperature — -0.24; -0.97; NA; 0.79 °C — p=<0.001
Phase 4 N=15 Effect of Topical Application of Iodex® Balm on Local Surface Temperature
Pain
Primary: Time to Significant Increase in Local Surface Temperature
Phase 2 N=25 Controlled Study of the Effect of Xenaderm® Ointment Vehicle Versus White Petrolatum on Healing
Wounds
Primary: Complete Wound Closure — 14.8; 14.9 days
N/A N=1 Sous Vide Rewarming for Frostbitten Extremities
Frostbite · Frostbite of Hand · Frostbite of Foot
Primary: Number of Limbs That Can be Rewarming Within 30 Minutes — 2 limbs
N/A N=20 Analysis of Human Tissue Temperature After Application of Therapeutic Modalities.
Humans · Young Adult · Health
Primary: The Most Effective Capacitance Shortwave Technique in Relation to Temperature Increase and Heat Conservation Measured by Infrared Thermography — 1.72; 0.58; 0.94; 7.9…
N/A N=7 Multicenter Sous Vide Frostbite
Frostbite · Frostbite of Hand · Frostbite of Foot
Primary: Rewarming — 7 Participants
Early Phase 1 N=21 Bronchoscopic Cryo-Immunotherapy of Lung Cancer
Advanced Non-small Cell Lung Cancer
Primary: Percentage of Successful Performances Among Patients in Whom BCI is Attempted — 100 Percentage of participants
N/A N=2 Feasibility Study: Heavy Water Tissue Labeling Protocol
Skin Laxity
Primary: Rate of Collagen Synthesis — 15.71; 21.22; 36.11; 51.80 percentage of new collagen synthesized
N/A N=20 Evaluation of the Ulthera® System and Efficacy Correlation to Morphological Differences
Facial and Neck Skin Laxity
Primary: Determine if There is a Correlation Between D90 Quantitative Efficacy Results of the Eyebrow and Lower Face Region With Where the TCPs Produced During Ultherapy…
Phase 1 N=30 StrataGraft® Skin Tissue as an Alternative to Autografting Deep Partial-Thickness Burns
Skin Wound · Burns · Trauma-related Wound
Primary: Number of Participants With Wound Closure of the Treatment Sites at Three Months — 29; 29 Participants