N/A N=57 Insulin-sensitive Obesity: Lessons From Longitudinal Data
Insulin Sensitivity/Resistance · Obesity
Primary: Insulin Sensitivity — 0.0105; -0.0076; 0.0041 micro mol/min/Kg/mU/L/year
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=28 Effect of Insulin Sensitizer Therapy on Atherothrombotic and Inflammatory Profiles Associated With Insulin Resistance
Type 2 Diabetes · Insulin Resistance · Metabolic Syndrome
Primary: Change From Baseline in Insulin Sensitivity as Measured by Glucose Infusion Rate (GIR) — 17.95; 1.68 micromols/kg of FFM/minute — p=<0.001
Phase 1 N=33 Contribution of Hyperinsulinemia vs. Hyperglycemia to Insulin Resistance in Type 1 Diabetes and Maturity Onset Diabetes of the Young, Type 2 (MODY2)
Type 1 Diabetes Mellitus · Maturity-Onset Diabetes of the Young, Type 2 · MODY2
Primary: Whole-body Glucose Utilization (Rd) — 8.5; 11.0; 12.1 mg/kg FFM/min
N/A N=41 Fatty Acid Oxidation Defects and Insulin Sensitivity
Very Long-chain Acyl-CoA Dehydrogenase Deficiency · Trifunctional Protein Deficiency · Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency
Primary: Glucose Disposal Rate (Rd)- the Rate of Glucose Infusion to Maintain Euglycemia During Steady State Insulin Infusion in mg/Min — 709; 429; 842; 497 mg/min — p=0.136
N/A N=103 Impact of INsulin Sensitivity on Cardiovascular Risk Markers During 10-20 Years of FOllow up
Diabetes Mellitus · Hypertension · Ischemic Heart Disease
Primary: Exploring Insulin Sensitivity After 10-20 Years of Follow-up — 7 mg/kg/min — p=<0.05
N/A N=32 Insulin Sensitivity in Patients With Atopic Dermatitis
Atopic Dermatitis/Eczema · Type 2 Diabetes
Primary: Insulin Sensitivity Difference Between Patients With Atopic Dermatitis and Controls — 9.8; 9.2 mg glucose/kg body mass/minute
N/A N=20 Protection Against Insulin Resistance in Obesity
Obesity · Insulin Resistance
Primary: Insulin Sensitivity — 273; 817 nmol/kg FFM/min /(µU/mL Insulin)
N/A N=11 Insulin Variance Throughout the Day
Insulin Sensitivity
Primary: Difference in Glucose Tolerance Between Morning at 7:00 AM and Evening at 7:00 PM — 163; 203 mg/dl — p=0.02
N/A N=25 Mechanisms of Insulin Resistance in Humans
Inflammation · Insulin Resistance
Primary: Insulin Signaling With Lipid Infusion — 0.4334; 0.7276; 0.5264; 0.3534 ratio
Phase 2 N=6 Role of Growth Hormone Antagonism in Modulating Insulin Sensitivity in Subjects With Pre-diabetes
Diabetes · Metabolic Syndrome · Insulin Resistance
Primary: Insulin Sensitivity — 3.06; 3.33 units on a scale
Phase 2 N=35 Insulin Resistance and Testosterone in Women
Insulin Resistance · Postmenopause
Primary: Percent Change in Free Testosterone (T) — -6.9; -35.8; 12.1 percent change
Phase 2 N=24 Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion
Metabolic Syndrome X
Primary: Triglycerides Levels at Week 12 — 210.6; 235.8 mg/dL — p=0.131
N/A N=28 Dopamine and Insulin Resistance
Obesity
Primary: Striatal DRD2 Receptor Binding — 28; 33; 32; 33 ratio — p=<0.05
N/A N=21 Insulin and Polycystic Ovary Syndrome
PCOS
Primary: Renal Clearance of D-chiroinositol (DCI) at 12 Days — 4.75; 5.16 ml/min
Phase 2 N=17 Effect of Salicylate on Glucose Metabolism in Insulin Resistance States
Insulin Resistance
Primary: Glucose — 7.1; 6.4 mmol/L
Phase 1 N=12 Effect of Vitamin D Replacement on Insulin Sensitivity
Insulin Sensitivity
Primary: M Value (Insulin Stimulated Glucose Uptake) — 4.1; 5.6; 4.7; 5.5 mg/kg.min — p=0.4
N/A N=11 Acute Cardiovascular and Metabolic Effects of Exercise Training in Individuals With Insulin Resistance
Insulin Resistance
Primary: Insulin Sensitivity After 5-7 Days of Exercise — 3; 2.5 index score — p=<0.05
N/A N=35 Insulin Sensitivity, Impaired Counterregulation, and Glucose Variability
Type 1 Diabetes Mellitus
Primary: Insulin Sensitivity — 3.37*10^-4 1/min per uU/mL
Phase 2 N=44 Effects of Dapagliflozin on Insulin Resistance and Insulin Secretion in Subjects With Type 2 Diabetes
Type 2 Diabetes Mellitus
Primary: Adjusted Mean Percent Change From Baseline in Insulin Sensitivity at Week 12 (Last Observation Carried Forward [LOCF]) — -9.99; 7.98 % Change of Baseline Insulin…
N/A N=60 Wholegrain Cereal Diet and Insulin Sensitivity
Metabolic Syndrome
Primary: Insulin Sensitivity (Si) — 3.03; 3.15 104xmin-1/microU/ml — p=<0.05
N/A N=113 Aerobic Plus Resistance Training and Insulin Sensitivity in African American Men
Insulin Resistance · Type 2 Diabetes
Primary: Insulin Response to an Oral Glucose Tolerance Test Over 20 Weeks. — 110.51; 106.64; 90.68; 80.23 uU/mL
Phase 3 N=31 Omega-3 Fatty Acids and Insulin Sensitivity
Insulin Resistance
Primary: Insulin Sensitivity by Hyperinsulinemic-euglycemic Clamp at Baseline and 6 Month Follow up — 10.92; 10.39; 10.16; 10.80 mg/kg FFM/min
N/A N=23 Insulin Resistance in Adolescents
Insulin Resistance
Primary: Linear Relationship Between HOMA-IR and Cognitive Function (R-squared) — 0.205; 0.299; 0.738; 0.0264 R-squared — p=0.162
Phase 4 N=32 Effects of Dapagliflozin 10 mg on Insulin Resistance in Patients With Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus
Primary: Adjusted Change From Baseline in Skeletal Muscle Insulin-stimulated Gluocose Uptake — 0.28; 0.28 umol/min/kg — p=0.9984
N/A N=12 A Study to Determine Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Type 1 Diabetes
Diabetes Mellitus, Type 1
Primary: Change in Insulin Sensitivity Assessed as Glucose Infusion Rates — 8.6; 8.1 mg/kg FFM/min — p=<0.01
N/A N=58 Molecular Mechanisms of Exercise Benefits to Insulin Resistant People
Insulin Resistance · Obesity
Primary: Change in Muscle Strength — 0.37; -0.2 Ratio
Phase 3 N=71 Salsalate Therapy to Reduce Insulin Resistance and Cardiovascular Risk
Atherosclerosis · Cardiovascular Disease · Inflammation
Primary: Change in Systemic Glucose Disposal- Glucose Infusion Rates — 1; 6 percent change from baseline — p=<0.05
Phase 2 N=20 Effect of Resveratrol on Age-related Insulin Resistance and Inflammation in Humans
Type 2 Diabetes Mellitus · Insulin Resistance
Primary: Peripheral Insulin Sensitivity (RD) Measured by the Change in Glucose Rates of Disappearance With Resveratrol or Placebo at Baseline and at 4 Weeks. — 6.573; 7.272…
Phase 2 N=24 Effect of Banaba (Lagerstroemia Speciosa) on Metabolic Syndrome, Insulin Secretion and Insulin Sensitivity
Metabolic Syndrome X
Primary: Triglyceride Levels at Week 12 — 148.0; 199.9 mg/dL — p=0.021
Phase 4 N=23 Insulin Sensitivity and Beta Cell Function After Carbohydrate Loading in Hip Replacement Surgery
Insulin Sensitivity
Primary: Change in Insulin Sensitivity — 3.2; 2.4 mg/(kg min)