Clinical Trial Search

Primary: Number of Subjects With Single Negative Polymerase Chain Reaction (PCR) Result and 3 Negative Culture Assays — 96.6 percentage of participants

Primary: Eradication of Staphylococcus Aureus (SA) Carriage at All 4 Body Sites Tested. — 13; 41 Participants

Primary: Number of Participants With Recurrent Methicillin-resistant Staphylococcus Aureus (MRSA) Colonization — 2; 3 Participants

Primary: Number of Participants With MRSA Carriage at 1 Week Post Decolonization With Retapamulin or Placebo — 2; 13 Participants — p=0.0004

Primary: Change in the Abundance of Staphylococcus Aureus in the Nose After Decolonization — -781 fg/uL

Primary: The Presence of MRSA on Repeated Swabs to Assess the Efficacy of These Medications on Clearing MRSA Colonization — 12; 14; 0 Participants

Primary: Number of Participants Eradicated of S. Aureus Carriage - 1 Month After Intervention — 24; 35; 35; 34 Participants

Primary: Change in S. Aureus/MRSA Colony Forming Units (CFU) in Nasal Swab Specimen After Treatment in Patients Who Presented With a Positive for S. Aureus/MRSA…

Primary: Number of Participants With Incidence of SSTI at 3 Months After Decolonization — 23; 23 Participants — p=0.757

Primary: Proportion of Participants With MRSA Clearance — 8; 4 Participants — p=0.320

Primary: Number of Participants With Eradiction of S. Aureus From the Oropharyngeal at 7 Days — 18; 7 Participants

Primary: Time to MRSA Infection — 67; 98; 68; 98 Participants — p=0.026

Primary: Number of Participants With Solicited Adverse Events (AEs) During Days 1-7 — 2; 1; 17; 4 participants

Primary: MRSA Transmission — 0.20; 0.02; 0.11; 0.01 Proportion of swabs positive for MRSA

Primary: Change in Eczema Area and Severity Index (EASI)Scores According to Location — -1.06; -0.57; -4.94; -0.88 Change in EASI Score

Primary: Plasma Retapumulin Pharmacokinetic Parameters by Treatment at Days 1 and 3 Evaluated by Plasma AUC After Dosing — 0.8663; 0.3816; 4.2802; 2.0881 ng.h /mL

Primary: Number of Index Patients Eradicated of S. Aureus Carriage - 1 Month After Performing Decolonization Measures — 39; 35 Participants — p=1.00

Primary: Number of Participants With PGA of 0 or 1 — 22; 14 participants — p=0.035

Primary: Incidence of Skin and Soft Tissue Infection (SSTI) — 303; 439; 461 participants

Primary: Number of Patients MRSA Free by Induced Sputum Respiratory Tract Culture — 2; 3 Participants

Primary: Recurrence of Cutaneous Abscess — 5; 7 Participants

Primary: Number of Participants With Antibiotic Usage at the Time of the ED Visit — 97; 96 Participants

Primary: Apparent Eradication of Nasal Carriage of SA — 9 participants

Primary: Recurrent Infection — 1; 3; 1 participants

Primary: Carrier Rate for Staphylococcus Aureus — 20.8 percentage of subjects

Primary: Main Outcome: Patients With Nosocomial MRSA Clinical Cultures — 0.92; 0.75; 0.63 hazard ratio — p=0.01

Primary: Vancomycin-Resistant Enterococcus (VRE) Colonization — 0; 0; 30; 33 participants with VRE colonization — p=0.671

Primary: Apparent Eradication of Nasal SA After the Last Dose of XF-73 Based on Semi-quantitative SA Scores From a Broth Enrichment Method. — 3; 1; 4 participants — p=0.792

Primary: Acquisition of Methicillin-resistant Staph Aureus (MRSA) Colonization or Infection — 9; 10 participants — p=>0.05

Primary: Number of Participants With Clinical Cure as of the Test-of-Cure (TOC) Visit in the Per Protocol Population — 457; 487; 182; 187 participants