N/A N=731 Impact of Deep Versus Standard Muscle Relaxation on Intra-operative Safety
Neuromuscular Blockade · Rocuronium · Anesthetics
Primary: Classic Score>1 — 66; 54 participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=19 Fade Upon TOF Stimulation Induced by Succinylcholine
Muscle Relaxants
Primary: Fade on Train of Four Stimulation — 0.85; 0.64; 0.66; 0.68 Ratio
Phase 4 N=240 Orphenadrine and Methocarbamol for LBP
Low Back Pain
Primary: Functional Impairment as Measured on the Roland Morris Disability Questionnaire — 10.9; 9.4; 8.1 units on a scale
Phase 4 N=320 Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain
Low Back Pain
Primary: Change in Functional Impairment as Measured by the Roland Morris Disability Questionnaire (RMDQ) — 10.1; 11.2; 10.6; 11.1 units on a scale
Phase 4 N=49 The Muscle Relaxation-study
Cholecystectomy, Laparoscopic
Primary: The Percentage of Patients With Optimal Surgical Space Conditions ( 1 at a 4-step Scale) Assessed at the Time During Surgery, When View Was Less — 28; 4 percentage of…
Phase 4 N=189 Best Management of Muscle Relaxation- Objective Monitoring
Residual Paralysis, Post Anesthesia
Primary: Incidence of Postoperative Residual Neuromuscular Blockade at Time of Extubation — 0 Participants
Phase 2 N=61 Comparison of Ibuprofen, Cyclobenzaprine, or Both for Acute Cervical Strain: A Randomized Clinical Trial
Cervical Strain
Primary: Pain
Phase 3 N=300 The Effect of Pretreatment With Roc on Succinylcholine Myalgias
Myalgia
Primary: Myalgias Perceived at 3 Hours — 81; 83; 83; 15 Participants
Phase 4 N=172 Muscle Relaxation for Pediatric Adenotonsillectomy
Tonsillectomy
Primary: Cumulative Intra- and Postoperative Opioid Consumption — 0.209; 0.188 IV morphine milligram equivalent/kg — p=0.123
Phase 3 N=180 Cyclobenzaprine HCl Extended Release 15 mg Versus Placebo in Treatment of Cervical and/or Lower Back Pain Due to Muscle Spasms of Local Origin
Neck Pain · Back Pain · Spasm
Primary: Percentage of Participants With Subject's Rating of Medication Helpfulness Impression on Day 3 of Treatment — 20.0; 28.9; 60.0; 46.7 percentage of participants — p=0.6179
Phase 3 N=201 Study of Recovery of Strength After Surgery Comparing Two Different Medications for Reversal of Muscle Relaxant
Surgery
Primary: Measure Participants' Recovery Time Post-Surgery — 3.59; 3.62 hours
Phase 4 N=40 A Randomized Controlled Crossover Study Comparing Sugammadex and Placebo
Posterior Cervical Decompression and Fusion
Primary: Changes Motor Evoked Potentials (MEPs) Amplitude at 3 Minutes — 652.9; 20.6; 2153.4; 55 micro volts — p=<0.01
Phase 2 N=4 Mexiletine for Muscle Cramps in Charcot Marie Tooth Disease
Charcot Marie Tooth Disease
Primary: Number of Participants With a Decrease in Cramp Duration — 2; 0 participants
Phase 4 N=23 Mexiletine for the Treatment of Muscle Cramps in ALS
Muscle Cramps in Amyotrophic Lateral Sclerosis
Primary: Daily Muscle Cramps — 6.1; 4.7; 4.9; 2.5 Cramps per 24 hours
Phase 3 N=1,008 Reevaluation Of Systemic Early Neuromuscular Blockade
Acute Respiratory Distress Syndrome
Primary: Hospital Mortality to Day 90 — 288; 289; 213; 216 Participants — p=0.93
Phase 3 N=840 Study to Evaluate Two Formulations of Carisoprodol in Subjects With Musculoskeletal Spasm of the Lower Back
Lower Back Pain
Primary: Subject Rated Change Relief From Starting Backache of Pain on a 100-point Visual Analog Scale — 16.4; 15.5; 15.2 mm
Phase 4 N=116 Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements?
Arthropathy of Hip
Primary: Surgical Conditions — 1; 2; 11; 10 Participants
Phase 3 N=840 A Study to Evaluate Two Formulations of Carisoprodol in Subjects With Musculoskeletal Spasm of the Lower Back
Lower Back Pain
Primary: Subject Rating of Pain on a 100-point Visual Analog Scale (VAS) — 27.5; 28; 28.6 mm
N/A N=40 Beneficial Effects of Magnesium Supplementation On Idiopathic Muscle Cramps
Muscle Cramp
Primary: Change in Frequency of Leg Cramps — .99; .53 Cramps per week
N/A N=32 Neuromuscular Blocking Agents in the Elderly
Elective Surgery
Primary: Onset Time — 135; 90 seconds — p=<0.001
Phase 2 N=10 Safety and Efficacy of Baclofen for Treatment of Muscle Spasms in Patients With Cirrhosis: A Pilot Study
Muscle Cramps · Cirrhosis
Primary: Number of Participants With Adverse Events as a Measure of Safety and Tolerability (Headache) — 3 participants
Phase 4 N=45 Premedication for Non-Emergency Endotracheal Intubation In the NICU
Respiratory Distress Syndrome
Primary: Present the Percentage of Participants With an Excellent Ease of Intubation Rating — 91; 17 % reported as excellent
Phase 2 N=415 Tolperisone in Acute Muscle Spasm of the Back
Back Pain · Acute Pain · Back Spasm Upper Back
Primary: Mean Effect Size in Subjected-Rated Pain — -4.2; -4.0; -3.7; -4.4 score on a scale
Phase 4 N=79 Use of Sugammadex for Reversal of Paralysis in Microlaryngoscopy
Microlaryngoscopy · Rigid Bronchoscopy
Primary: Time to Extubation After End of Procedure — 11.06; 10.36 Minutes
Phase 4 N=20 Botox as a Treatment for Interstitial Cystitis in Women
Painful Bladder Syndrome · Interstitial Cystitis
Primary: Chronic Prostatitis Symptom Index (CPSI-F) — 29.6; 35.2 Total CPSI-F
Phase 4 N=30 Ropinirole for the Treatment of Muscle Cramps in Patients With Cirrhosis
Muscle Cramp · Cirrhosis
Primary: Frequency of Muscle Cramps as Assessed by Patient Survey — 1.14; 1.23 score on a scale
Phase 2 N=21 Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand
Dystonia
Primary: Physician Global Perception of Change - Blinded Rater 1 — 1; 1; 1; 4 Participants
N/A N=53 Sedation During Muscle Biopsy in Patients With Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy
Primary: Time to Sedation Score of 3-4 — 3.7; 2.8 minutes
N/A N=50 Effect of Tetanus on Neuromuscular Junction Monitor Performance in Pediatric Patients
Muscle Relaxation
Primary: Train of Four 0,9 (90%) — 49.9; 41.7 minutes
Phase 4 N=84 Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade at the End of Kidney Transplantation Surgery
Kidney Transplant; Complications · Postoperative Residual Curarization · Postoperative Residual Weakness
Primary: Number of Patients With Hypoventilation in Post-anesthesia Care Unit (PACU) — 22; 23 Participants