Phase 4 N=129 Non Invasive Mechanical Ventilation in Acute Cardiogenic Pulmonary Edema
Acute Cardiogenic Pulmonary Edema
Primary: Number of Patients Who Were Intubated — 5; 4; 10 participants
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N/A N=114 Non-invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema
Cardiogenic Pulmonary Oedema
Primary: Need for an Endotracheal Intubation Within Seven Days After Onset of Cardiopulmonary Edema at the Intensive Care Unit — 5; 5 Participants — p=1.000
N/A N=19 A Comparison of Non-invasive Ventilation Methods Used to Prevent Endotracheal Intubation Due to Apnea in Very Low Birth Weight Infants
Apnea of Prematurity
Primary: Number of Participants Who Were Intubated — 6; 8 Participants
N/A N=32 Non Invasive Ventilation as Airway Clearance in Patients With Cystic Fibrosis
Cystic Fibrosis
Primary: Lung Function: Lung Clearance Index — 9; 9.7 lung clearance index
N/A N=77 Non-invasive Ventilation vs Oxygen Therapy After Extubation Failure
Respiratory Failure
Primary: Rate of Intubation — 10; 23 participants
N/A N=200 Trial of Non Invasive Ventilation for Respiratoy Distress Syndrome
Prematurity · Respiratory Distress Syndrome
Primary: Need for Endotracheal Ventilation in the First 72 hs of Life — 34; 25 participants — p=<0.05
Phase 3 N=124 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome)
RDS of Prematurity
Primary: Duration of NIV Support — 89; 87 HOURS — p=< 0.05
N/A N=23 Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Newly Diagnosed Patients
Nocturnal Hypoventilation · Neuromuscular Disease · Chest Wall Disorder
Primary: Overnight Mean Oxygen Saturation — 96; 96 % SaO2 — p=0.13
N/A N=68 Clinical Stabilization of Hypercapnia: NIPPV v HVNI
Hypercapnic Respiratory Failure · Chronic Obstructive Pulmonary Disease · Dyspnea
Primary: Rated Perceived Dyspnea [RPD] — 5.4; 5.6; 3.97; 4.54 units on a scale (0-10)
N/A N=30 In-home Evaluation of a Noninvasive Open Ventilation System in Patients With Severe Respiratory Insufficiency
Pulmonary Disease, Chronic Obstructive · Airflow Obstruction, Chronic · Chronic Obstructive Airway Disease
Primary: Activity Endurance Time — 7.24; 13.38 minutes — p=<0.05
N/A N=1,493 A Trial Comparing Noninvasive Ventilation Strategies in Preterm Infants Following Extubation
Intubated Infants Were Intend to Extubation Using Noninvasive Ventilation Strategies
Primary: Duration of Invasive Mechanical Ventilation — 6.3; 7.8; 7.3 day
N/A N=22 Non-invasive Ventilation System in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary Disease, Chronic Obstructive · Airflow Obstruction, Chronic · Chronic Obstructive Airway Disease
Primary: Device Tidal Volume — 180 mL
N/A N=28 Study of Standard Noninvasive Positive Pressure Ventilation (NIPPV) and Low Expiratory Pressure NIPPV in ALS Patients
Amyotrophic Lateral Sclerosis
Primary: Hours of NIPPV Usage — 49.94; 45.75 hours
N/A N=37 Preoxygenation With Nasal Cannula and Noninvasive Positive Pressure Ventilation
Hypoxia
Primary: End-tidal Oxygen — 78.1; 78.6 End tidal oxygen saturation percentage
N/A N=34 Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator
Bronchopulmonary Dysplasia
Primary: Number of Days Being Intubated — 12.4; 6.2 days
N/A N=20 High Intensity Non-Invasive Positive Pressure Ventilation (HINPPV)
Chronic Obstructive Pulmonary Disease (COPD)
Primary: Daytime Partial Pressure of Carbon Dioxide in Arterial Blood (PaCO2) — 53; 50 mmHg — p=0.01
N/A N=8 Noninvasive Ventilation Masks Carbon Dioxide Clearance in Normal Volunteers
CO2 Clearance · Mask Comfort · Rebreathing Exhaled Gas
Primary: Carbon Dioxide Clearance From the Masks — 1.83; 1; 0.49; 0 percentage of CO2 inspired
N/A N=56 Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures
Severe Obesity · Hypoxia
Primary: Percentage of Participants With an Oxygen Desaturation Event ≤ 94% — 57.1; 14.3 percentage of participants
N/A N=18 A Feasibility Study Evaluating the Use of a Non-invasive Ventilation Mask
Noninvasive Ventilation · Respiratory Insufficiency
Primary: Clinician Assessment of Use With a Questionnaire — 5; 4 units on a scale
N/A N=40 Nasal Noninvasive NAVA in the Very Low Birth Weight Infant
Inadequate; Pulmonary Ventilation, Newborn · Infant, Very Low Birth Weight
Primary: Change in Partial Pressure of Carbon Dioxide on Capillary Blood Gas — 0.019 mm Hg
N/A N=83 Non-Invasive Ventilation Via a Helmet Device for Patients Respiratory Failure
Acute Respiratory Distress Syndrome · Shock · Ventilatory Failure
Primary: Need for Endotracheal Intubation — 24; 8 Participants
Phase 4 N=64 Mask Leak With Nasal Cannula in Noninvasive Positive Pressure Ventilation
Mechanical Ventilation Pressure High
Primary: Face Mask Leak Measured in Liters Per Minute by the Noninvasive Positive Pressure Ventilation Machine — 0; 0 Liters per minute
Phase 3 N=16 Physiologic Comparison Between NIV-NAVA and PS in Preterm Infants
Noninvasive Neurally Adjusted Ventilatory Assist and Pressure Support in Preterm Infants
Primary: Trigger Delay — 35.2; 294.6 ms — p=<0.001
N/A N=174 Comparison of Oxygenation and Ventilation With a Novel Nasal Mask Versus Standard of Care During Colonoscopy
Colonoscopy · Oxygenation · Ventilation
Primary: Time to First Intervention — 10; 19 minutes
N/A N=22 Randomized Crossover of NAVA and Synchronized Intermittent Pressure Ventilation in Neonates and Infants
Respiratory Insufficiency · Infant, Newborn, Disease
Primary: Respiratory Severity Score (MAP X FiO2) — 3.83; 3.82; 3.46; 3.86 score on a scale
N/A N=102 Nasal HFOV Versus Nasal SIPPV in Neonate Following Extubation: RCT Crossover Study
High-Frequency Ventilation · Intermittent Positive-Pressure Ventilation · Newborn Morbidity
Primary: Partial Pressure CO2 (pCO2) : Data From the Crossover Phase of the Study — 38.7; 36.8 mm Hg
N/A N=25 Servo-Ventilation In-lab PSG Evaluation
Sleep Apnea Syndromes
Primary: Average Apnea Hypopnea Index Among Different Polysomnography Devices. — 18.4; 25.4; 24.1; 19.2 events per hour
N/A N=340 NHFOV vs. NCPAP as a Primary Treatment to Neonatal Respiratory Distress Syndrome(NRDS)
Preterm Infants
Primary: Number of Participants Who Required Intubation — 26; 15 Participants
N/A N=47 Pilot Study of High-flow Humidified Nasal Oxygen During Breaks From Noninvasive Ventilation
Acute Respiratory Failure · Treatment With Noninvasive Positive Pressure Ventilation
Primary: Length of Stay on Noninvasive Ventilation (NIV) — 1404; 1386 Minutes
N/A N=751 Protocolized Post-Extubation Respiratory Support Study
Mechanical Ventilation Complication · Acute Respiratory Failure · Intubation Complication
Primary: Reintubation — 57; 52 Participants