Phase 2 N=28 Circadian Rhythms of Aqueous Humor Dynamics in Humans
Glaucoma
Primary: Intraocular Pressure — 17.6; 16.4; 20.2; 17.0 mmHg — p=<.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=35 Circadian Ocular Perfusion Pressure and Ocular Blood Flow
Glaucoma
Primary: Mean Change From Baseline in Overall Diastolic Ocular Perfusion Pressure at Week 6 — 2.6; 0.8 mmHg (millimeters of mercury)
N/A N=66 Physiologic Phacofluidics: Ghost Protocol
Cataract
Primary: Change in Early Post Operative Central Corneal Thickness — 623.9; 650.2 microns
N/A N=35 Aqueous Suppressant Versus Aqueous Outflow on Ocular Blood Flow
Glaucoma
Primary: 6-month Change in Ophthalmic Artery (OA) Peak Systolic Velocity (PSV) — -.70; 1.84 cm/sec — p=.4414
N/A N=33 Analysis of the Eye in Patients With Primary Open-Angle Glaucoma and a Visual Field Defect in One Eye
Glaucoma
Primary: Lamina Cribrosa (Boundaries of the Retinal Layers) Measurements — 264.3; 273.3; 276.2 micro-ohms
N/A N=20 Effect of Topical Phenylephrine 2.5% on EVP in Normal Human Eyes
Assess Phenylephrine on EVP and IOP
Primary: Change in Episcleral Venous Pressure (EVP) — 7.2 mmHg — p=<0.01
N/A N=46 The Effects of an Antioxidant Formulation on Ocular Blood Flow
Primary Open Angle Glaucoma
Primary: Change in Superior Retinal Capillary Blood Flow (% Zero Pixels) — -0.026; 0.011 % zero pixels — p=0.0016
N/A N=7 Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)
Glaucoma
Primary: Presence of Retinal Vascular Dysregulation (RVD) — 7; 4 Participants
Phase 1 N=29 Phase I Clinical Trial to Evaluate the Safety and Tolerability of Ophtalmic Solution PRO-201
Myopia
Primary: Number of Unexpected Adverse Events — 41 adverse events
N/A N=65 Ocular Characteristics in Contact Lens and Spectacle Wear
Visual Acuity
Primary: Non-Invasive Break Up Time (NIBUT) or Non-Invasive Keratograph Break Up Time (NIKBUT) — 8.28; 11.10 Seconds
Phase 4 N=35 Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study
Glaucoma; Drugs · Normal Tension Glaucoma · Primary Open-angle Glaucoma
Primary: Changes in Vessel Density in Treatment Groups Assessed by OCT Angiography — -0.51; 2.59; -0.96; 0.96 percent change
Phase 4 N=11 Wearing-Off Period of Pharmacological Dilation and Anisocoria
Anisocoria
Primary: Number of Participants With Constricting Response to Pilocarpine 1% in the Pharmacologically Dilated Eye — 3 Participants
N/A N=155 Eye Movements, Visual Perception and Attention
Vision
Primary: Average Performance in Visual Tasks — 74 percentage
N/A N=63 Intraoperative Ocular Pressure in Lumbar Spine Fusion Patients
Raised Ocular Pressure
Primary: Change in Intraoperative Ocular Pressure in Lumbar Spine Fusion Patients Head Raised 10 Degrees or Kept in Neutral Position — 9.26; 13.79 mm Hg
Phase 3 N=38 Evaluation of the Performance of Non-molded Soft Contact Lenses
Ametropia
Primary: Visual Acuity — 0.01; -0.07 logMAR
N/A N=16 Effect of Travoprost 0.004% on Retinal Oximetry in Primary Open Angle Glaucoma
Primary Open Angle Glaucoma
Primary: Blood Oxygenation — 60; 60; 60 percentage of oxygenation
N/A N=218 Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications
Uveitis · Iritis · Iridocyclitis
Primary: Macular Thickness Measured With the OCT; in Relation to Age, Sex, Reproductive Factors and the Use of Anti-inflammatory Eye Drops in Health; in Uncomplicated Anterior…
N/A N=100 Evaluation of Retinal Microvascular Change That May Develop in After Open Globe Injury
Eye Injury Trauma
Primary: Corneal Thickness — 542.23; 546.16; 544.32 microns
N/A N=303 Optical Coherence Tomography (OCT) Data Collection Study
Glaucoma
Primary: Primary Endpoints — 97.2; 83.9; 73.9; 336.1 microns
Phase 4 N=106 Evaluation of Hyperemia With the Use of Ocular Prostaglandin Analogues
Open Angle Glaucoma · Ocular Hypertension
Primary: Change From Baseline in Mean Conjunctival Hyperemia Scores at Month 3 — 0.74; 0.86; 0.74; 0.05 Scores on Scale
N/A N=129 Optical Coherence Tomography Angiography Evaluation of Ocular Changes in Patients With Carotid Artery Stenosis
Carotid Stenosis
Primary: Radical Peripapillary Capillaries Vessel Density — 55.95; 57.24 percentage of vessel
Phase 4 N=94 Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface
Myopia · Refractive Error
Primary: Corneal Epithelial Immune Dendritic Cell Density (Central Cornea) — 46.2; 44.8; 62.3 cells/mm2
Phase 4 N=13 Assessment of Alcon's Ocular Image Quantification System
Allergic Conjunctivitis
Primary: Change From Baseline in Patient-Assessed Ocular Itching, Environmental Exposure Chamber (EEC), at 3 Hours — -1.63; -1.11 Units on a scale
Phase 2 N=18 Efficacy of OC-01 Nasal Spray on Goblet Cell and Meibomian Gland Stimulation
Dry Eye Disease
Primary: Mean Change in Goblet Cell Area — -38.8; -6.7 um
N/A N=42 Investigation of Ocular Signs & Symptoms in Wearers Fitted With Contact Lenses Following Digital Device Use
Visual Performance
Primary: Subjective Overall Comfort — 65.0; 53.6; 61.9 units on a scale
N/A N=27 The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure
Glaucoma, Open-angle · Hypertension, Ocular
Primary: Change in Intraocular Pressure From Baseline at Visit 3 — 21.1; 18.2; 20.0; 17.1 mmHg
N/A N=72 Ocular Comfort and the "Aging" Lens (ERBIUM)
Refractive Error
Primary: Phase 3: Ocular Comfort, Lens Age 1 Day, Hour 1 — 76; 88 Units on a scale
Phase 4 N=62 The Development of New Functions of Esculin and Digitalis Glycosides Eye Drops: A Study on the Treatment of Presbyopia
Presbyopia
Primary: DCNVA — 8; 1 Participants
N/A N=25 Contact Lens Adaptation in Neophytes
Contact Lens Comfort
Primary: Between-Group Difference in Eye Comfort as Measured by the Ocular Surface Disease Index (OSDI) — 10.8; 16.3 Units on a Scale — p=0.83
Early Phase 1 N=33 Aqueous Humor Dynamics and Brimonidine
Intraocular Pressure
Primary: Seated Day-time IOP 9 am and 11 am, Supine Day-time IOP 9 am and 11 am, and Seated Night-time IOP 9 pm and 11 pm — 18.1; 20.3; 18.0; 19.9 mmHg