Clinical Trial Search

Primary: Change in Pain Assessment — 2.9; 4.0 score on a scale

Primary: Change in Pain Score at 60 Minutes — 2.18; 4.01 units on a scale

Primary: NRS-Pain With Movement on POD 2 — 2.83 units on a scale

Primary: Change of Pain Relief From Baseline to the End of Treatment Using the 5-point Visual Rating Scale (VRS) — 3; 23; 28; 20 Participants

Primary: Part 1: Change From Baseline in Pain Intensity at Hour 6 Using the Thermal Suprathreshold Pain in the Ultraviolet-B (UVB) Burn Pain Model — 0.73; -0.64; -0.36; 0.36…

Primary: Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores — 4.4; 3.5; 3.9; 4.3 units on a scale

Primary: 10 Day Silverman Integrated Analgesic Assessment (SIA) Score — 1.4; -1.4 score on a scale — p=0.7957

Primary: Credibility and Expectancy Questionnaire (CEQ)- Credibility Subscale — 8 Participants

Primary: Intervention Effects on Mechanical Sensitivity Threshold — 125.6; 93.56; 63.04; 70.27 100*Value at 24 hours/Value at Baseline

Primary: Time Until PCA Discontinued After the Operation — 76.4; 86.7 hours

Primary: Safety and Tolerability as Assessed by Number of Participants With Treatment-Emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs) — 94; 2 Participants

Primary: Change in Pain Score — -1.3; -2.4; -3.0 score on a scale

Primary: Change in Pain From Before Medication Administered (Baseline) to One-hour Post-baseline — 3.0; 3.0; 3.4; 3.1 Units on a scale — p=0.69

Primary: Postoperative Pain Levels — 1.3160; 2.1362 score on a scale

Primary: Change in Functional Impairment as Measured by the Roland Morris Disability Questionnaire — 11.1; 11.9 units on a scale

Primary: Change in Pain: Visual Analog Scale (VAS) — 2.1 units on a scale (centimeters)

Primary: Clinical Improvement in NRS Pain Score — 62; 63 Participants

Primary: Cumulative Opioid Consumption — 97; 117 mg morphine equivalents — p=0.08

Primary: Total Rescue Opioid Consumption — 166.9; 179.9; 180.2 µg/kg — p=0.736

Primary: Analgesic Efficacy — 26.5; 32.3 percentage of patients with NRS≥4

Primary: Verbally Administered Numeric Rating Scale (VNRS) — 68; 66 units on a scale — p=0.56

Primary: Change From Baseline in Time Weighted Average (TWA) Pain Intensity (PI) on a Numeric Rating Scale (NRS) Due to Self-paced Walks on Day 3 — -0.927; -1.54; -1.73 units on…

Primary: Change in Pain Intensity, Baseline to 60 Minutes After Medication Infused — 5.8; 5.2 units on a scale

Primary: Total Opiate Requirement — 1.19; 1.01 mg/kg

Primary: Sum of Pain Intensity Difference (SPID) for Low Back Pain - Summary Statistics at 120 Hours (With Imputation) — 264.6; 264.0 Units on a scale — p=0.9703

Primary: Change From Baseline of Pain as Described by Numeric Rating Scale (NRS) [Minimum:0, Maximum 10] at 15 Minutes — 3.5; 6.0 units on a scale

Primary: Opioid Requirements in Cesarean Section (C-section) Patient Population — 44; 48; 58; 57 mg

Primary: FLACC Pain Score Greater Than or Equal to 4 — 58; 69 Participants

Primary: Mean Area Under the Curve (AUC) of the Numeric Rating Scale (NRS) of Pain Intensity Scores From Time 0 (When First Dose on Day 1 is Administered) Through 24 Hours…

Primary: Severity of Acute Pain — 46; 31 mm — p=0.05