N/A N=193 Cognitive-Behavior Therapy for Posttraumatic Headache
Post-traumatic Headache · PTSD
Primary: Headache-related Disability Scores on the Headache Impact Test 6 (HIT-6) — 66.1; 66.1; 65.2; 61.9 score on a scale — p=<0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=16 Gabapentin for Headache in Aneurysmal Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage
Primary: Average Numeric Pain Score — 5.2; 5.8 score on a scale — p=0.7
N/A N=23 Intracranial Pressure in Experimental Models of Headache
High Altitude Headache
Primary: Change in Optic Nerve Sheath Diameter by Ultrasonography — 0.02; 0.02 mm — p=0.98
Phase 4 N=62 Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine
Headache · Pregnancy Related · Occipital Nerve Block
Primary: Number of Participants With Response to Occipital Nerve Block in Pregnancy — 20; 16 Participants — p=0.30
Phase 4 N=25 Erenumab for Idiosyncratic Facial Pain
Facial Pain · Rhinosinusitis
Primary: Change in Mean Number of Days Per Month With Significant Mid-facial Pain or Pressure — -6.0; -5.8 days per month — p=0.96
N/A N=80 Use of Ibuprofen and Acetaminophen for Treatment of Acute Headache Post Concussion in Children
Concussion · Headache
Primary: Number of Headache Days — 4; 3; 3; 4 number of headache days
Phase 3 N=160 Metoclopramide for Post Traumatic Headache
Post-Traumatic Headache
Primary: 0-10 Pain Scale on Which 0 = no Pain and 10= the Worst Pain Imaginable — 5.2; 3.8 units on a scale
Early Phase 1 N=22 Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Chronic Pain · Opiate Dependence · Lower Back Pain
Primary: Change in Quantitative Pain Testing Following Active TMS Compared to Baseline — 1.4; .3 Change from Baseline (degrees C) — p=.83
N/A N=21 Transcranial Alternating Current Stimulation in Back Pain- Pilot Sudy
Chronic Low Back Pain
Primary: Change in Heart Rate Variability Before and After 40-minute Stimulation — 0.206; -0.01 ms^2 — p=.319
Phase 4 N=5 An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute Headache
Pain
Primary: Change in Pain Score at 60 Minutes — 4; 5 score on a scale
N/A N=334 Expanded Development of a Medical Device Utilizing an EEG-Based Algorithm for the Objective Quantification of Pain
Chronic Pain
Primary: Area Under the Curve of Classification Versus Patient Self Report of Pain vs no Pain State — .70 probability
N/A N=38 Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Chronic Pain · Chronic Lower Back Pain · Back Pain
Primary: Changes in Patient Reported Pain and Discomfort — 47; 13; -30; -18 percent change from baseline
Phase 4 N=122 Olanzapine for Acute Headaches
Headache
Primary: Change in Pain Scores Based on Patient Questionnaire — -2.95; -1.79; -4.49; -2.65 units on a scale of 1-10
N/A N=41 A Research Study to Examine Cutaneous Allodynia and Cluster Headache
Cluster Headache
Primary: Prevalence of Allodynia in Subjects With Cluster Headache — 20 participants
N/A N=91 Oxygen Therapy for the Treatment of Undifferentiated Headache in the Emergency Department
Headache
Primary: Time to Relief (Min) — 92.2; 83.9; 35.4 Minutes
N/A N=102 A Randomized Multicentre Study for the Acute Relief of Episodic and Chronic Cluster Headache.
Cluster Headache
Primary: Comparison of the Headache Pain Free Attack Rates at 15 Minutes Following the Treatment — 495; 400; 67; 46 Number of attacks
Phase 2 N=89 Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
Posttraumatic Headache · Combat Disorders · Post Concussion Syndrome
Primary: Headache Diary — -10.7; -6.9 headaches per month — p=0.034
N/A N=309 Prospective ED Headache Cohort Study
Headache
Primary: Number of Participants Who Report Moderate or Severe Pain Within 24 Hours of Emergency Department(ED) Discharge — 53; 6; 20 Participants
Phase 2 N=45 Endogenous Modulation and Central Sensitization in New Daily Persistent Headache ( NDPH ) in Children
New Daily Persistent Headache (NDPH)
Primary: Pain Intensity — 5.82; 4.92 score on a scale
N/A N=150 Study of Intramuscular Ropivacaine Injections for Treatment of Pediatric Headache
Headache · Migraine
Primary: The Primary Outcome Will be Pain Relief Sufficient for Discharge From the Emergency Department. — 16; 14; 2 Participants
Phase 2 N=40 Sumatriptan as Treatment for Post-traumatic Headache
Post-traumatic Headache
Primary: Change in Headache Relief — 23 percentage of headaches resolved — p=.079
Phase 4 N=123 Metoclopramide Versus Ketorolac for Tension-type Headache
Headache
Primary: Change in Pain Score — 3.8; 5.1 units on a scale
Phase 2 N=21 Metoclopramide for Post-Traumatic Headache. A Pilot Study
Post-Traumatic Headache
Primary: Number of Participants With Sustained Headache Relief — 12 Participants
Phase 3 N=226 Ibuprofen Sodium Tension Headache Study
Pain
Primary: Time-weighted Sum of Pain Relief Rating and Pain Intensity Difference From 0-3 Hours (SPRID 0-3) for Ibuprofen Sodium Versus Placebo Tablet — 9.6; 3.5 units on scale…
Phase 4 N=89 Prazosin for Post-Concussive Headaches
Post-Traumatic Headache
Primary: Change From Baseline in Headache Frequency — 16.4; 18.5; -9.2; -7.4 headaches per month
N/A N=133 Effects of Expectations on Negative Affect, Perceived Cognitive Effort, and Pain
Placebo · Expectations
Primary: Behavioral: Within Participant Subjective Outcome Ratings of Acute Thermal Pain Following High Compared to Low Cues — 8.20 units on a scale — p=< .001
N/A N=89 Mindfulness and Mechanisms of Pain Processing in Adults With Migraines
Migraine
Primary: Change in Frequency of Migraine Days Per Month From Baseline — -1.6; -2.0 number of days
Phase 3 N=200 Study Evaluating A Novel Ibuprofen Formulation In Episodic Tension-Type Headache
Pain
Primary: Time-weighted Sum of Pain Relief Rating and Pain Intensity Difference From 0-3 Hours (SPRID 0-3) for Ibuprofen Sodium Versus Placebo Tablet — 11.2; 10.8 Units on a scale…
N/A N=21 Managing Pain and Cognitions in Older Adults With Mild Cognitive Impairment or Memory Related Problems and Chronic Pain
Chronic Pain · Mild Cognitive Impairment · Older Adults
Primary: Client Satisfaction Questionnaire 3-Item (CSQ-3): Number of Participants With Scores Above and Below Scale Midpoint — 8; 9; 0; 1 Participants
N/A N=11 Pain Control Using Neuromodulation in Patients Undergoing Definitive Chemoradiotherapy for Head and Neck Cancer
Cancer of Head and Neck
Primary: Visual Analog Scale (VAS) — 16; 2; 11; 0 score on a scale