Phase 4 N=393 Acetaminophen (APAP) +/- Oxycodone
Musculoskeletal Pain
Primary: Change in Pain Assessment — 2.9; 4.0 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=156 Acute Pain Genomic Study
Osteoarthritis · Postoperative Pain
Primary: NRS-Pain With Movement on POD 2 — 2.83 units on a scale
N/A N=41 Exercise Dosing for Pain in Healthy Participants
Pain
Primary: Intervention Effects on Mechanical Sensitivity Threshold — 125.6; 93.56; 63.04; 70.27 100*Value at 24 hours/Value at Baseline
N/A N=78 Multicentre Observational Study on the Wound Pain Relief Properties of ORTODERMINA®
Wound Healing Disorder
Primary: Change of Pain Relief From Baseline to the End of Treatment Using the 5-point Visual Rating Scale (VRS) — 3; 23; 28; 20 Participants
N/A N=20 Usability of a Multimodal External Neuromodulatory Device to Relieve Acute Low Back Pain
Low Back Pain · Low Back Sprain · Low Back Pain, Recurrent
Primary: Change in Pain: Visual Analog Scale (VAS) — 2.1 units on a scale (centimeters)
Phase 4 N=60 A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal Pain
Pain
Primary: Change in Pain Score at 60 Minutes — 2.18; 4.01 units on a scale
N/A N=10 Virtual Reality for Pain in Acute Orthopedic Injuries
Injuries · Injury Arm · Injury;Sports
Primary: Credibility and Expectancy Questionnaire (CEQ)- Credibility Subscale — 8 Participants
Phase 4 N=200 Assessment and Prevention of Acute Post-herniotomy Pain
Hernia
Primary: Analgesic Efficacy — 26.5; 32.3 percentage of patients with NRS≥4
N/A N=1,602 A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial)
Acute Pain
Primary: 10 Day Silverman Integrated Analgesic Assessment (SIA) Score — 1.4; -1.4 score on a scale — p=0.7957
Phase 3 N=258 A Single-arm Study to Evaluate Safety and Effectiveness of VX-548 for Acute Pain
Pain
Primary: Safety and Tolerability as Assessed by Number of Participants With Treatment-Emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs) — 94; 2 Participants
Phase 3 N=645 NUCYNTA (Tapentadol Immediate Release) Versus Oxycodone Immediate Release in the Treatment of Acute Low Back Pain
Pain · Back Pain · Low Back Pain
Primary: Sum of Pain Intensity Difference (SPID) for Low Back Pain - Summary Statistics at 120 Hours (With Imputation) — 264.6; 264.0 Units on a scale — p=0.9703
N/A N=69 High Pain Intervention in Cesarean Sections
Other Chronic Postoperative Pain
Primary: Severity of Acute Pain — 46; 31 mm — p=0.05
N/A N=90 The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
Perforated Appendicitis
Primary: Time Until PCA Discontinued After the Operation — 76.4; 86.7 hours
Phase 2 N=239 Evaluate the Efficacy and Safety of ACP-044 for the Treatment of Acute Postoperative Pain Following Bunionectomy
Acute Postoperative Pain · Bunionectomy
Primary: Mean Area Under the Curve (AUC) of the Numeric Rating Scale (NRS) of Pain Intensity Scores From Time 0 (When First Dose on Day 1 is Administered) Through 24 Hours…
Phase 4 N=416 Comparative Efficacy of 4 Oral Analgesics
Pain
Primary: Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores — 4.4; 3.5; 3.9; 4.3 units on a scale
Phase 3 N=120 Ibuprofen With or Without Acetaminophen for Low Back Pain
Low Back Pain
Primary: Change in Functional Impairment as Measured by the Roland Morris Disability Questionnaire — 11.1; 11.9 units on a scale
N/A N=75 Patient Education to Improve Pain Management in Older Adults With Acute Musculoskeletal Pain: A Pilot Randomized Trial
Musculoskeletal Pain
Primary: Change in Pain Score — -1.3; -2.4; -3.0 score on a scale
Phase 4 N=119 Intravenous Acetaminophen for Non-Narcotic Postoperative Pain Management Following Knee Arthroscopy
Pain, Postoperative
Primary: Postoperative Pain Levels — 1.3160; 2.1362 score on a scale
Phase 1 N=22 A Study to Evaluate the Effect of Analgesics on a Walking Model of Knee Pain (0000-105)(COMPLETED)
Osteoarthritis
Primary: Change From Baseline in Time Weighted Average (TWA) Pain Intensity (PI) on a Numeric Rating Scale (NRS) Due to Self-paced Walks on Day 3 — -0.927; -1.54; -1.73 units on…
N/A N=150 Pain Control After Cardiac Surgery Using Intravenous Acetaminophen
Pain
Primary: Cumulative Opioid Consumption — 97; 117 mg morphine equivalents — p=0.08
N/A N=21 Transcranial Alternating Current Stimulation in Back Pain- Pilot Sudy
Chronic Low Back Pain
Primary: Change in Heart Rate Variability Before and After 40-minute Stimulation — 0.206; -0.01 ms^2 — p=.319
N/A N=16 Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain
Phantom Limb Pain · Postoperative Pain · Neuroma
Primary: Average Phantom Limb Pain (PLP) Score — 4.1; 3.1; 2.2; 3.0 score on a scale
Phase 3 N=352 A Study of Tapentadol Immediate-Release in the Treatment of Patients With Acute Pain From Bunionectomy
Hallux Valgus
Primary: Sum of Pain Intensity Differences (SPID) Over 48 Hours — 65.3; 131.7; 154.5 Scores on a scale — p=<0.001
Phase 4 N=12 Reduction in Pain Intensity Following IV or Oral Pain-relieving Products
Pain
Primary: Part 1: Change From Baseline in Pain Intensity at Hour 6 Using the Thermal Suprathreshold Pain in the Ultraviolet-B (UVB) Burn Pain Model — 0.73; -0.64; -0.36; 0.36…
Phase 4 N=159 IV Acetaminophen as an Analgesic Adjunct
Acute Pain
Primary: Change in Pain Intensity, Baseline to 60 Minutes After Medication Infused — 5.8; 5.2 units on a scale
Phase 2 N=162 Acetaminophen Versus IV Hydromorphone for Pain in the Elderly in the ED
Acute Pain
Primary: Clinical Improvement in NRS Pain Score — 62; 63 Participants
N/A N=60 Adjunct VR Pain Management in Acute Brain Injury
Traumatic Brain Injury · Headaches Posttraumatic · Trauma
Primary: Change in Pain Score — -0.92; -0.16; -1.24 score on a scale
N/A N=65 Nurse Initiated Acupressure for Pain Management
Pain, Postoperative · Pain, Acute
Primary: Visual Analogue Pain Scale — 3.03; 4.37 units on a scale — p=.048
Phase 3 N=1,000 Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain
Acute Pain · Low Back Pain, Mechanical
Primary: Pain Intensity — 2.8; 3.0; 2.8; 3.0 score on a scale — p=0.16
Phase 1 N=119 Dose Dependent Effects of tDCS on Post-Operative Pain
Total Knee Arthroplasty (Postoperative Pain) · Total Hip Arthroplasty(Postoperative Pain)
Primary: Post-operative Opioid Pain Medication Dose — 26.99; 31.12; 28.65; 33.15 mg of morphine equivalent dose (MED)