N/A N=34 Evaluation of the Role of Propionibacterium Acnes in the Inflammatory Lesions Associated With Acne Vulgaris
Acne
Primary: Level of IL-1β — 52.5; 361.2 pg/mg
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=12 Topical Treatment and Prevalence of P. Acnes
Surgical Site Infection
Primary: Number of Subjects With Positive Bacterial Growth Culture Per Treatment Arms — 10; 12; 10; 10 participants
Phase 4 N=40 Anti Propionibacterium(P.) Acnes Activity of Epiduo® Gel Compared to Benzoyl Peroxide (BPO) 2.5% Gel
Acne Vulgaris
Primary: Change From Baseline (Log10 Cfu/cm²) in Count of Follicular P. Acnes — -1.94; -1.56 Log10 cfu/cm²
Phase 4 N=30 Evaluate Effectiveness of Epiduo® Gel in Reducing Antibiotic Sensitive & Resistant Strains of Propionibacterium (P)Acnes
P Acnes Colonization
Primary: Change From Baseline in Quantitative Bacteriology Measurements at Week 4 — -1.6 log10 CFU/cm2
Phase 1 N=10 A Study of the Safety, Engraftment, and Action of NB01 in Adults With Moderate Acne
Acne Vulgaris
Primary: Number of Participants With Successful Engraftment of Probiotic Following a Single Application. — 2; 1 Participants
Phase 2 N=33 BPX-01 Minocycline 1% Topical Gel for Reduction of Propionibacterium Acnes
Acne Vulgaris
Primary: Logarithmic Change in Colony Counts of Facial Propionibacterium Acnes — -1.0376; -0.4614 log change in colony forming units
Phase 2 N=20 Photoactive Porphyrins (PAP) Levels After Topical Visonac Application in Acne Patients
Acne Vulgaris
Primary: Photoactive Porphyrins Level — 33.0; 24.8; 19.7 Fluorescence intensity unit
N/A N=80 Skin Prep to Reduce Postoperative Shoulder Infection
Shoulder Infection
Primary: Skin Swab and Culture With Colony Forming Units (CFUs) — 39; 51; 35; 22 negative skin cultures — p=0.68
Phase 1 N=36 A Study of the Safety, Engraftment, and Action of Multi-Dosed NB01 in Adults With Moderate Acne
Acne Vulgaris
Primary: Number of Participants With Changes in Local Skin Reactions — 19; 11; 2; 1 Participants
Phase 4 N=25 Profiling the Skin Microbiome in Response to Altreno in Acne Patients
Acne · Healthy
Primary: CLR-transformed Abundance of Any Significant Taxa — 3.29; -2.49; -1.59; -2.75 Relative Abundance
N/A N=36 Hydrogen Peroxide to the Wound Following Surgical Incision Affecting Cultures in Primary Shoulder Arthroplast
Primary Anatomic or Reverse Total Shoulder Arthroplasty
Primary: Number of Positive vs Negative Culture's Based on Skin Prep Method — 6; 6; 12; 11 Participants
N/A N=56 Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?
Osteoarthritis
Primary: Bacterial Culture — 14; 15 # Participants with Bacteria in Culture
Phase 2 N=22 Perimenstrual Acne With Clindamycin Phosphate and Benzoyl Peroxide
Actinic Keratosis
Primary: PGA Score — 0.53 score on a scale
Phase 2 N=150 Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Moderate to Severe Acne
Acne Vulgaris
Primary: Proportion of Success, Defined as Improvement of at Least 2 Grades From Baseline According to the IGA Scale Based on Facial Assessment — 16; 14.58; 11.54 Percentage of…
Phase 4 N=54 Comparative Antimicrobial Efficacy of Two Topical Acne Therapies for the Treatment of Facial Acne
Acne
Primary: Median Change in Total Propionibacterium Acne (P.Acne) Counts — -1.26; -0.08; -1.58; -0.67 P. acne counts
Phase 2 N=285 Double-Blind, Placebo-Controlled Study to Evaluate 3 Doses of a Novel Tetracycline in the Treatment of Facial Acne Vulgaris
Acne Vulgaris
Primary: The Absolute Change From Baseline in the Inflammatory Lesion Count at the Final Visit — 12.8; 14.4; 17.6; 17.1 Number of Inflammatory Lesions — p=0.4344
Phase 3 N=825 Bioequivalence Study of Two Treatments in the Treatment of Acne Vulgaris on the Face
Acne Vulgaris
Primary: Mean Percent Change From Baseline in the Papules and Pustules Lesion Count — 68.18; 63.56; 50.72 percentage of lesion change
Phase 3 N=1,180 A Study to Compare Clindamycin Phosphate and Benzoyl Peroxide Topical Gel 1.2%/2.5% to Acanya® Topical Gel in the Treatment of Acne Vulgaris
Acne
Primary: Mean Percent Change in the Inflammatory (Papules and Pustules) Lesion Count — 61.70; 63.89; 42.22 percent change of lesion counts
N/A N=10 Study of Two Different 10.0% Benzoyl Peroxide Creams for Mild to Moderate Acne Vulgaris
Acne Vulgaris
Primary: Number of Inflammatory Lesions (Papules and Pustules) — 6; 3; 10; 0 Lesions
Phase 2 N=20 Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Patients With Skin Type V or IV With Acne Vulgaris
Acne Vulgaris
Primary: Proportion of Patients With Moderate to Severe Hypopigmentation and Hyperpigmentation Assessed After Treatment — 0; 0 participants
Phase 4 N=186 A Treatment for Severe Inflammatory Acne Subjects
Acne Vulgaris
Primary: Change in Number of Inflammatory Lesions — -30.1 Inflammatory lesions
N/A N=100 Knowledge Evaluation and Assessment of the Effectiveness of an Education Intervention on Acne
Acne Vulgaris
Primary: Number of Correct Responses to Questionnaire Items Immediately Before and After and Educational Lecture — 79; 79; 74; 79 participants
Phase 4 N=10 A Study Evaluating the Efficacy and Safety of Clascoterone Cream 1% in Skin of Color Patients With Acne
Acne Vulgaris
Primary: The Primary Endpoint of This Study is the Percent of Patients Who Achieved Clear (0) or Almost Clear (1) on IGA Scale at Week 16 — 78 percentage of participants — p=<0.008
Phase 2 N=18 Open Label Photo-Documentation Study Of BPX-01 Minocycline Gel
Acne Vulgaris
Primary: Change From Baseline in Inflammatory Lesion Counts at Week 12 — 22.3; 19.0 inflammatory lesions
Phase 2 N=153 A Double Blinded, Prospective, Randomized, Vehicle Controlled Multi-center Study of Photodynamic Therapy With Visonac® Cream in Patients With Acne Vulgaris
Acne Vulgaris
Primary: Absolute Change From Baseline in Facial Inflammatory Lesion Count (Nodules, Papules, and Pustules). — -7.8; -15.6 lesion count — p=0.006
Phase 2 N=294 Efficacy Study in Patients With Acne Vulgaris.
Acne Vulgaris
Primary: Percent Change From Baseline to Week 12 in the Inflammatory (Papules and Pustules) Lesion Counts on the Face — -60.84; -62.17 percentage change in lesion counts — p=0.5947
Phase 2 N=431 A Study of a New Drug Treatment for Acne
Acne Vulgaris
Primary: Change in Total Acne Lesion Counts — -26.0; -25.2; -29.4; -33.1 Lesions
N/A N=20 Effect of Photodynamic Treatment on Skin Microbiome. Single Center Study
Postoperative Wound Infection Deep Incisional Surgical Site · Prosthesis and Implants · Surgical Site Infection
Primary: Number of Participants With Bacterial Growth Before and After Photodynamic Treatment and After Skin Antisepsis — 10; 10; 3; NA Participants
Phase 3 N=434 A Study of S6G5T3 in the Treatment of Acne Vulgaris
Acne Vulgaris
Primary: Percentage of Participants Achieving an IGA Score of Clear or Almost Clear and a Score ≥2 Grades Less Than Baseline — 25.4; 14.7 percentage of participants
Phase 3 N=459 Adapalene-BPO Gel Associated With Doxycycline Hyclate 100 mg in the Treatment of Severe Acne Vulgaris
Severe Acne Vulgaris
Primary: Percent Change From Baseline in Total Lesion Counts at Week 12. — -64; -41 % of change