Clinical Trial Search

Primary: Maximum Exercise Tolerance Testing

Primary: Cardiovascular Fitness as Determined by Lokomat Peak VO2 Assessments — 20.2; 12.9; 22.5; 11.6 ml/kg/min

Primary: Change in Gait Speed — 0.15; 0.075; 0.127 meters/second

Primary: Gross Motor Function Measure Dimension E — 15.6; 12.7; 18.7; 17.1 score on a scale

Primary: Change in Baseline Step Length Symmetry. That is, Whether the Steps With Right and Left Legs Are the Same Length. — 0.001; -0.078; -0.045; 0.144 ratio

Primary: Feasibility - # With > or = 60% Compliance, # Agreeing to Participate, # Returning for 3 Month Follow-up — 14; 10; 6 Participants

Primary: Safety — 0 adverse events

Primary: Change in Self-selected Gait Speed (Normalized) — -0.0010; 0.0163 dimensionless

Primary: Economy of Gait — 13.44; 12.67 ml/kg/min

Primary: 6 Minute Walk Test (Metres) — 54.3 metres

Primary: Partial Correlation Between Pelvis Displacement and Paretic Step Width During Gait (Change From Baseline) — -0.02; 0.12; -0.04; 0.05 Correlation coefficient — p=0.047

Primary: Change From Baseline of Lower Extremity Independence Time During 10 Min Standing Bout After 160 Sessions (1 Year) — 40.6 minutes

Primary: Self-selected Overground Walking Speed — 0.72; 0.65 meters/s — p=0.72

Primary: Pattern of Gross Motor Development — 28.2; 28.3 months

Primary: Motor Section of the Unified Parkinson's Disease Rating Scale (UPDRS-III) — 23.35; 22.96; 22.46; 18.81 units on a scale (0-4)

Primary: Lower Extremity Motor Activity Log - Real World Use of the Affected Lower Extremity in Daily Activities. — 6.3; 6.4; 7.3; 7.2 score on a scale

Primary: Number of Subjects Reporting Any Fall — 60; 77 Participants

Primary: Walking Speed as Assessed by 25' Timed Walk — 22.7; 10.6; 23.9; 9.8 seconds

Primary: Self-selected Floor Walking Velocity Change From Baseline to Post-training and Retention — 56.0; 55.5; 50.9; 56.1 cm/sec — p=< 0.01

Primary: Change in Locomotor Performance During Treadmill Walking — 0.8 m/s

Primary: Fastest Walking Speed — 149.5; 153.1; 156.1; 164.3 cm/s

Primary: Change in Walking Performance High Versus Low Frequency SBLTT Groups — 1872; 1551 strides per day — p=.39

Primary: Change in Motor Evoked Potential (MEP) Amplitude in the Tibialis Anterior Muscle at the End of Training. — -1.75; -2.01 Amplitude percentage of Mmax

Primary: 10 m Walk Test — 0.64; 0.79 m/s

Primary: Peak Oxygen Uptake (V'O2peak) — 1461; 1494 mL/min — p=0.53

Primary: Percentage of Heart Rate Readings Within the Target Zone Achieved During HIT Gait Training Session — 72.67 Percentage of readings

Primary: Functional Ambulation Scale (FAC) — 1; 0 units on a scale

Primary: 10 Meter Walking at Preferred Speed — 0.04; 0.06 meters per second

Primary: Force Symmetry Ratio During Gait — 0.71; 0.83 ratio

Primary: Percentage Change in Step Length Asymmetry — 11.6 % change in asymmetry