Phase 4 N=50 Alternative Sedation During Bronchoscopy
Sedation
Primary: Decreased Minute Ventilation — 0.736; 0.764 percentage of baseline — p=<0.0001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=150 Patient-controlled Sedation With Propofol Versus Combined Sedation During Bronchoscopy
Sedation, Bronchoscopy
Primary: Discharge Assessment Using PADSS After 2 Hours Number of Patients Reaching PADSS Score 10 After 2 Hours — 19; 30; 45 Participants
Phase 4 N=500 Bispectral Index-guided Sedation for Flexible Bronchoscopy
Flexible Bronchoscopy
Primary: The Number of Participants With Any Hypoxemia Event During Flexible Bronchoscopy — 97; 88 participants — p=0.05
Phase 4 N=50 Dexmedetomidine for Sedation of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Bronchoscopy
Primary: Hypoxemia During Maintenance — 8; 14 Participants
N/A N=102 Non-anesthesiologist-administered Propofol During the Flexible Bronchoscopy
Conscious Sedation Failure During Procedure
Primary: Change in Transcutaneous CO2 Pressure — 43.6; 45.6 Unit of Measure "mmHg" — p=0.281
Phase 3 N=50 Sedation Using Intranasal Dexmedetomidine in Upper Gastrointestinal Endoscopy
Gastrointestinal Disease
Primary: Consumption of Rescue Patient Controlled Propofol — 42.4; 28.6 mg
Early Phase 1 N=300 Sedation Regimens in GI Endoscopy
Anesthesia · Endoscopy · Colonoscopy
Primary: Pain Felt During the Procedure — 0.29; 0.30 score on a scale
Phase 4 N=173 Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy
Hypoxemia
Primary: Effect Site Concentration When Conscious Level Reaches OAAS-3 — 2.3; 2.2; 2.5; 2.2 ug/ml
Phase 3 N=446 A Phase III Study of Remimazolam in Patients Undergoing Bronchoscopy
Bronchoscopy
Primary: Number of Participants With a Successful Procedure — 250; 3; 24 Participants — p=<0.0001
N/A N=11 Sedation in Patients at Risk for Upper Airway Collapse
Obstructive Sleep Apnea
Primary: Respiratory Disturbance Index — 57.52; 21.32 events per hour
Phase 4 N=135 Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy
Procedural Sedation
Primary: Level of Sedation Throughout the Entire Procedure — 22; 9; 10; 1 participants
Phase 3 N=1,000 Safety and Effectiveness of a Computer-Assisted Personalized Sedation (CAPS) Device for Propofol Delivery During Endoscopy
Colonoscopy · Endoscopy, Digestive System · Conscious Sedation
Primary: Area Under the Curve for Oxygen Desaturation (AUCDesat) — 23.6; 88.0 seconds*percent of oxygen desaturation — p=0.028
N/A N=60 Conscious Sedation for Epilepsy Surgery
Epilepsy
Primary: Patients Satisfaction — 6.33; 6.45 score on a scale
Phase 4 N=114 Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy
Colonoscopy
Primary: Percentage of Subjects Ready for Discharge in Each Group at 30 Minutes Post Procedure — 26; 44 Participants
N/A N=28 Prophylactic Bronchoscopy After Inhalation Injury in Burn Patients
Inhalation Injury · Pneumonitis · Pneumonia
Primary: All Cause Mortality — 0; 1 participants
N/A N=452 Use of Capnography in EGD and Colonoscopy With Moderate Sedation.
Hypoxia · Apnea · Hypotension
Primary: Number of Participants Experiencing Hypoxia During Capnography Monitoring. — 54; 59; 61; 63 Participants
Phase 4 N=40 Sedation Effect of Dexmedetomidine Versus Remifentanil to Fibreoptic Intubation
Intubation; Difficult
Primary: Endoscopy Scores — 3; 2 units on a scale
N/A N=10 Phamacological Reversal of Airway Instability During Sedation
Upper Airway Obstruction
Primary: AHI - Apnea Hypopnea Index — 14.5; 27.9; 11.3; 12.1 events per hour
N/A N=41 Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
Morbid Obesity · Noninvasive Ventilation · Deep Sedation
Primary: Ability to Maintain Oxygenation — 0.55; 0.61 manipulations
N/A N=112 The Need of Fiberoptic Bronchoscopy for Placing an Endobronchial Blocker
Neoplasms, Pulmonary · Thoracic Diseases
Primary: Surgical Grading for Lung Isolation — 12; 13; 15; 14 participants
N/A N=51 Correlation Endoscopic View of Airway Obstruction With RRa in OSA Patients Under DEX Monitored With SedLine EEG
Obstructive Sleep Apnea (OSA)
Primary: Number of Subjects in Which Electroencephalogram (EEG) Signals is Collected — 47 Participants
Phase 4 N=107 Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department
Pain
Primary: Patients With Clinical Signs of Respiratory Depression or Sub Clinical Respiratory Depressions Measured by Capnography and Pulse Oximetry. — 22; 21 Participants
N/A N=73 Effect of Sedation on Diagnostic Injections
Sacroiliac Joint Pain · Sympathetically Maintained Pain
Primary: Pain Score — 2.2; 3.4 units on a scale
N/A N=120 Optimal Procedural Sequence in Same-day Bidirectional Endoscopy: A Prospective Randomized Controlled Study
Endoscopy · Moderate Sedation
Primary: Sedative Doses of Fentanyl — 1.09; 1.28 mcg/kg — p=<0.0001
Phase 4 N=50 Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block
Shoulder Pain
Primary: Number of Participants That Need an Airway Intervention. — 0; 5 participants
Phase 4 N=68 Etomidate vs. Midazolam for Sedation During ERCP
Choledocholithiasis · Cholangiocarcinoma · Pancreatitis
Primary: Number of Intervention — 1.9; 7.5 Number of intervention — p=0.05
N/A N=1,771 The Emergency Department Sedation Pilot Trial
Mechanical Ventilation · Respiratory Failure
Primary: Participant Recruitment — 196; 219 Participants
N/A N=139 Effect of Nasal Positive Airway Pressure Versus Standard Care on Oxygenation and Ventilation During Propofol-based Sedation for Colonoscopy in Patients With High Risk of Airway Obstruction
Obstructive Sleep Apnea, Obesity
Primary: Time Taken From Initiation of Induction to the First Airway Intervention — 5; 10 minutes
N/A N=53 Sedation During Muscle Biopsy in Patients With Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy
Primary: Time to Sedation Score of 3-4 — 3.7; 2.8 minutes
N/A N=20 Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Diagnostic Bronchoscopy
Bronchoscopy
Primary: Lowest Intraoperative Peripheral Oxygen Saturation (SpO2) — 94.7; 98.7 percentage of oxygen — p=0.09